4-chloro-5-fluoro-2-iodoaniline
- CAS No.
- 1094759-93-9
- Chemical Name:
- 4-chloro-5-fluoro-2-iodoaniline
- Synonyms
- 4-chloro-5-fluoro-2-iodoaniline;4-Chloro-5-fluoro-2-iodo-phenylamine;Benzenamine, 4-chloro-5-fluoro-2-iodo-
- CBNumber:
- CB73086156
- Molecular Formula:
- C6H4ClFIN
- Molecular Weight:
- 271.46
- MDL Number:
- MFCD26407029
- MOL File:
- 1094759-93-9.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
4-chloro-5-fluoro-2-iodoaniline price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS111125 | 4-Chloro-5-fluoro-2-iodoaniline 97% | 1094759-93-9 | 1g | $133 | 2026-06-04 | Buy |
| Activate Scientific | AS111125 | 4-Chloro-5-fluoro-2-iodoaniline 97% | 1094759-93-9 | 5g | $471 | 2026-06-04 | Buy |
| Matrix Scientific | 299163 | 4-Chloro-5-fluoro-2-iodoaniline | 1094759-93-9 | 250.00mg | $43 | 2026-05-19 | Buy |
| Matrix Scientific | 299163 | 4-Chloro-5-fluoro-2-iodoaniline | 1094759-93-9 | 1.00g | $108 | 2026-05-19 | Buy |
| Matrix Scientific | 299163 | 4-Chloro-5-fluoro-2-iodoaniline | 1094759-93-9 | 5.00g | $404 | 2026-05-19 | Buy |
4-chloro-5-fluoro-2-iodoaniline Chemical Properties, Uses, Production
Synthesis
367-22-6
1094759-93-9
The general procedure for the synthesis of 4-chloro-5-fluoro-2-iodoaniline from 3-fluoro-4-chloroaniline was as follows: iodide iodide (20.6 mL, 1 M dichloromethane solution, 20.6 mmol) was added slowly and dropwise to a solution of 4-chloro-3-fluoroaniline (2 g, 13.7 mmol) in methanol (35 mL) at 0 °C. The reaction mixture was stirred at room temperature for 1 hour. Subsequently, volatiles were removed by distillation under reduced pressure, water was added and the mixture was extracted with dichloromethane. The organic layers were combined, washed with water, dried over anhydrous sodium sulfate, and then the solvent was evaporated. The remaining crude product was purified by silica gel column chromatography using three different ratios of eluents in sequence (heptane/ethyl acetate 98:2-93:7, and twice heptane/ethyl acetate 98:2-95:5), resulting in 4-chloro-5-fluoro-2-iodoaniline (2.51 g, 67% yield) as a dark red solid. Mass spectrometry (ESI) analysis showed a molecular ion peak of 272.1 (M + H)+.
References
[1] Organic Process Research and Development, 2010, vol. 14, # 5, p. 1248 - 1253
[2] Patent: WO2013/64465, 2013, A1. Location in patent: Page/Page column 168
[3] Patent: US2013/116234, 2013, A1. Location in patent: Paragraph 0940; 0941
[4] Patent: US2009/5410, 2009, A1. Location in patent: Page/Page column 78
[5] Patent: WO2013/56060, 2013, A1. Location in patent: Paragraph 00237
4-chloro-5-fluoro-2-iodoaniline Preparation Products And Raw materials
4-chloro-5-fluoro-2-iodoaniline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 9814 | 58 |
| Yancheng KangdiSen Pharmaceutical Co., Ltd. | 13812573443;18052965989 | tongbenwan22@163.com | China | 1975 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Wuxi KaideRui Pharmaceutical Technology Co., Ltd | 19906241957 | 1557216087@qq.com | China | 1853 | 55 |
| Dalian lichuang Chemical Co., Ltd | 0411-0411-00000000 13644282108 | 3500508746@qq.com | China | 2942 | 55 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| Shandong utilizing biological technology co., LTD | 18669728830 15966937598 | 3407650895@qq.com | China | 5183 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Suzhou bayaoke Biotechnology Co., Ltd | 18626188356 | 1058187422@qq.com | China | 510 | 58 |
