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ChemicalBook >> CAS DataBase List >>4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester

4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester

4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester Structure
4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester structure
CAS No.
205448-64-2
Chemical Name:
4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester
Synonyms
lenvaint-B;idene)methyL;4-(((2,2-dimethyL;Lenvatinib Impurity 120;)amino)-2-methoxybenzoate;-4,6-dioxo-1,3-dioxan-5-yL;METHYL4-[(2,2-DIMETHYL-4,6;methyl 4-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methylamino);4-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methylamino)-2-methoxybenzoate;Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate
CBNumber:
CB73116376
Molecular Formula:
C16H17NO7
Molecular Weight:
335.31
MDL Number:
MFCD26395147
MOL File:
205448-64-2.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:40
Product description Number Pack Size Price
Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate 97% M58699 250mg $70
Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate 97% M58699 1g $77
Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate 97% M58699 5g $80
Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate 97% M58699 10g $250
Methyl 4-(((2,2-Dimethyl-4,6-Dioxo-1,3-Dioxan-5-Ylidene)Methyl)Amino)-2-Methoxybenzoate 97% AA002A03 1g $26
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4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester Properties

Boiling point 547.8±50.0 °C(Predicted)
Density 1.360±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
pka -3+-.0.40(Predicted)
Appearance Off-white to yellow Solid

4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Synthonix M58699 Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate 97% 205448-64-2 250mg $70 2026-05-06 Buy
Synthonix M58699 Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate 97% 205448-64-2 1g $77 2026-05-06 Buy
Synthonix M58699 Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate 97% 205448-64-2 5g $80 2026-05-06 Buy
Synthonix M58699 Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate 97% 205448-64-2 10g $250 2026-05-06 Buy
aablocks AA002A03 Methyl 4-(((2,2-Dimethyl-4,6-Dioxo-1,3-Dioxan-5-Ylidene)Methyl)Amino)-2-Methoxybenzoate 97% 205448-64-2 1g $26 2026-05-28 Buy
Product number Packaging Price Buy
M58699 250mg $70 Buy
M58699 1g $77 Buy
M58699 5g $80 Buy
M58699 10g $250 Buy
AA002A03 1g $26 Buy

4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester Chemical Properties,Uses,Production

Synthesis

5-(METHOXYMETHYLENE)-2,2-DIMETHYL-1,3-DIOXANE-4,6-DIONE

15568-85-1

Methyl 4-amino-2-methoxybenzoate

27492-84-8

4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester

205448-64-2

The general procedure for the synthesis of methyl 4-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)methylamino)-2-methoxybenzoate from 5-(methoxymethylenyl)-2,2-dimethyl-1,3-dioxane-4,6-dione and 2-methoxy-4-aminobenzoic acid methyl ester was as follows: first, 2-methoxy-4-aminobenzoic acid methyl ester (14.15 g, 78 mmol) was suspended in isopropanol and heated at 50 °C. Subsequently, 5-(methoxymethylenyl)-2,2-dimethyl-1,3-dioxohexane-4,6-dione (14.8 g, 80 mmol) was added in batches over 10 min. The reaction mixture was heated to reflux for 30 minutes. After completion of the reaction, the mixture was cooled to room temperature and the precipitate formed was collected by filtration. The precipitate was washed with isopropanol and dried under vacuum to afford the target product 5-((3-methoxy-4-methoxycarbonylanilino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (25.2 g, 96% yield).

References

[1] Patent: US6809097, 2004, B1. Location in patent: Page column 67
[2] Patent: EP1724268, 2006, A1. Location in patent: Page/Page column 48
[3] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1649 - 1667
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1668 - 1680

4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester synthesis

2033-24-1
27492-84-8
149-73-5
205448-64-2
Synthesis of 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester from 2,2-Dimethyl-1,3-dioxane-4,6-dione and Methyl 4-amino-2-methoxybenzoate and Trimethoxymethane

4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester Preparation Products And Raw materials

Raw materials

5-(METHOXYMETHYLENE)-2,2-DIMETHYL-1,3-DIOXANE-4,6-DIONE Methyl 4-amino-2-methoxybenzoate 2,2-Dimethyl-1,3-dioxane-4,6-dione Trimethoxymethane Triethyl orthoformate
4-Aminosalicylic acid

1of2

Preparation Products

7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylic acid Methyl 4-chloro-7-Methoxyquinoline-6-carboxylate Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate

4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester Suppliers

Global( 84)Suppliers
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Moxin Chemicals 		+86-17320513646 +8617320513646 anna@molcoo.com China 10000 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Jinan Shengqi pharmaceutical Co,Ltd 		86+18663751872 christine@shengqipharm.com CHINA 491 58
Shanghai Yingrui Biopharma Co.,Ltd 		21-33585366 export01@shyrchem.com CHINA 1319 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 +8613506123987 marketing1@neostarunited.com China 8828 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15074 58
Baoji Guokang Healthchem co.,ltd 		+8615604608665 15604608665 dominicguo@gk-bio.com CHINA 9414 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19987 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Supplier Advantage
Moxin Chemicals 		58
career henan chemical co 		58
Jinan Shengqi pharmaceutical Co,Ltd 		58
Shanghai Yingrui Biopharma Co.,Ltd 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58
AFINE CHEMICALS LIMITED 		58
Baoji Guokang Healthchem co.,ltd 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
Labnetwork lnc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58

View Lastest Price from 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Lenvatinib Impurity pictures 2025-12-16 Lenvatinib Impurity
205448-64-2
 US $0.00-0.00 / mg 10mg 95%+ 100000 Moxin Chemicals
4-[(2,2-Dimethyl-4,6-dioxo-[1,3]-dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester pictures 2024-11-26 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]-dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester
205448-64-2
 US $0.00-0.00 / kg 1kg 98% 1 ton Nanjing Fred Technology Co., Ltd
4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate methyl 4-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methylamino) METHYL4-[(2,2-DIMETHYL-4,6 lenvaint-B )amino)-2-methoxybenzoate 4-(((2,2-dimethyL -4,6-dioxo-1,3-dioxan-5-yL idene)methyL Benzoic acid, 4-[[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]amino]-2-methoxy-, methyl ester 4-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methylamino)-2-methoxybenzoate 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester 4- Lenvatinib Impurity 120 methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoatemethyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate 205448-64-2