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LY2157299

LY2157299 Structure
LY2157299 structure
CAS No.
924898-09-9
Chemical Name:
LY2157299
Synonyms
LY2157299 (hydrate);Galunisertib Hydrate;Galunisertib Monohydrate;4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide,hydrate
CBNumber:
CB73122674
Molecular Formula:
C22H21N5O2
Molecular Weight:
387.44
MDL Number:
MOL File:
924898-09-9.mol
MSDS File:
SDS
Last updated:2026-07-27 17:00:41
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LY2157299 Properties

FDA UNII 338K210Q5W

LY2157299 Chemical Properties, Uses, Production

Uses

Galunisertib monohydrate is an oral and selective TGF-β receptor type I (TGF-βRI) kinase inhibitor with an IC50 of 56 nM.

References

[1] Bueno L, et al. Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-beta kinase antagonist, in mice. Eur J Cancer. 2008 Jan;44(1):142-50. DOI:10.1016/j.ejca.2007.10.008
[2] Cong L, et al. Targeting the TGF-β receptor with kinase inhibitors for scleroderma therapy. Arch Pharm (Weinheim). 2014 Sep;347(9):609-15. DOI:10.1002/ardp.201400116
[3] Serova M, et al. Effects of TGF-beta signalling inhibition with galunisertib (LY2157299) in hepatocellular carcinoma models and in ex vivo whole tumor tissue samples from patients. Oncotarget. 2015 Aug 28;6(25):21614-27 DOI:10.18632/oncotarget.4308
[4] Herbertz S, et al. Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway. Drug Des Devel Ther. 2015 Aug 10;9:4479-99. DOI:10.2147/DDDT.S86621

LY2157299 Preparation Products And Raw materials

Raw materials

Preparation Products

LY2157299 Suppliers

Global Suppliers ( 9)
Supplier Tel Email Country ProdList Advantage
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Hubei Wande Chemical Co., Ltd 15377098680 15377098680 1148280011@qq.com China 9436 58
Hubei Qifei Pharmaceutical Chemical Co., Ltd 027-59322506 18071128681 1438082200@qq.com China 9554 58
Zhengzhou convergence chemical co., LTD 037155153829 18003835034 3897192574@qq.com China 9982 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Hubei Chenghai Chemical Co., Ltd 027-59220433 18327245847 1400838877@qq.com China 9527 58
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 ivan@atkchemical.com China 32997 60
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Jia Xing Isenchem Co.,Ltd 66
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Hubei Wande Chemical Co., Ltd 58
Hubei Qifei Pharmaceutical Chemical Co., Ltd 58
Zhengzhou convergence chemical co., LTD 58
TargetMol Chemicals Inc. 58
Hubei Chenghai Chemical Co., Ltd 58
ATK CHEMICAL COMPANY LIMITED 60
TargetMol Chemicals Inc. 58

View Latest Price from LY2157299 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Galunisertib Monohydrate pictures 2026-07-27 Galunisertib Monohydrate
924898-09-9
 $1520.00-2500.00 10g TargetMol Chemicals Inc.

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Galunisertib Hydrate 4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide,hydrate LY2157299 (hydrate) Galunisertib Monohydrate 924898-09-9