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trimethyl pyridine-2,4,6-tricarboxylate

CAS No.
25309-39-1
Chemical Name:
trimethyl pyridine-2,4,6-tricarboxylate
Synonyms
trimethyl pyridine-2,4,6-tricarboxylate;pyridine-2,4,6-tricarboxylic acid trimethyl ester;2,4,6-Pyridinetricarboxylic acid, 2,4,6-trimethyl ester
CBNumber:
CB73147453
Molecular Formula:
C11H11NO6
Molecular Weight:
253.21
MDL Number:
MFCD26792768
MOL File:
25309-39-1.mol
Last updated:2026-05-28 03:50:49

trimethyl pyridine-2,4,6-tricarboxylate Properties

Melting point 148-150 °C
Boiling point 385.0±37.0 °C(Predicted)
Density 1.289±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
pka -3.11±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H319-H335-H315
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P

trimethyl pyridine-2,4,6-tricarboxylate price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 293467 Trimethyl pyridine-2,4,6-tricarboxylate 25309-39-1 250.00mg $50 2026-05-19 Buy
Matrix Scientific 293467 Trimethyl pyridine-2,4,6-tricarboxylate 25309-39-1 1.00g $126 2026-05-19 Buy
Matrix Scientific 293467 Trimethyl pyridine-2,4,6-tricarboxylate 25309-39-1 5.00g $422 2026-05-19 Buy
Synthonix T54447 Trimethyl pyridine-2,4,6-tricarboxylate 97% 25309-39-1 100mg $107 2026-05-06 Buy
Synthonix T54447 Trimethyl pyridine-2,4,6-tricarboxylate 97% 25309-39-1 250mg $116 2026-05-06 Buy
Product number Packaging Price Buy
293467 250.00mg $50 Buy
293467 1.00g $126 Buy
293467 5.00g $422 Buy
T54447 100mg $107 Buy
T54447 250mg $116 Buy

trimethyl pyridine-2,4,6-tricarboxylate Chemical Properties, Uses, Production

Synthesis

Methanol

67-56-1

Pyridine-2,4,6-tricarboxylic acid

536-20-9

trimethyl pyridine-2,4,6-tricarboxylate

25309-39-1

The general procedure for the synthesis of trimethyl pyridine-2,4,6-tricarboxylate from methanol and pyridine-2,4,6-tricarboxylic acid was as follows: the target compound pyridine-2,4,6-tricarboxylic acid trimethyl ester 2 was prepared according to the literature methodology [44].This was carried out as follows: pyridine-2,4,6-tricarboxylic acid 1 (10 g, 47 mmol) was dissolved in methanol (70 mL), added concentrated sulfuric acid ( 98%, 5 mL) and heated under reflux conditions for 6 h until the complete disappearance of raw material 1 was shown by thin layer chromatography (TLC) monitoring. Upon completion of the reaction, the reaction solution was neutralized with calcium carbonate (CaCO3), the insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure to remove the solvent. The crude product was purified by recrystallization from toluene to give the white crystalline target product 2. Yield: 95%; melting point: 161 °C. Infrared spectrum (IR, KBr, cm1): 3462, 3304 (NH stretching vibration), 2976, 1737 (C=O stretching vibration), 1644 (C=N stretching vibration), 1488 (C-N stretching vibration). Nuclear magnetic resonance hydrogen spectrum (1H NMR, DMSO-d6) δH: 8.54 (2H, apparent single peak), 3.95 (9H, apparent single peak).

References

[1] Bioorganic Chemistry, 2014, vol. 57, p. 148 - 154
[2] Tetrahedron, 1980, vol. 36, # 1, p. 123 - 129
[3] Monatshefte fuer Chemie, 1917, vol. 38, p. 239
[4] Helvetica Chimica Acta, 2004, vol. 87, # 1, p. 156 - 166

trimethyl pyridine-2,4,6-tricarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

Global Suppliers ( 29)
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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd. 0431-80514535 13634302652 Extension@chemextension.com CHINA 967 58
trimethyl pyridine-2,4,6-tricarboxylate pyridine-2,4,6-tricarboxylic acid trimethyl ester 2,4,6-Pyridinetricarboxylic acid, 2,4,6-trimethyl ester 25309-39-1