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PRN694

PRN694 Structure
PRN694 structure
CAS No.
1575818-46-0
Chemical Name:
PRN694
Synonyms
PRN694;PRN694,PRN-694;(E)-N-(1-(((R)-1-Acryloylpyrrolidin-2-yl)methyl)-5-((((S)-3,3-dimethylbutan-2-yl)amino)methyl);N-(1-(((R)-1-Acryloylpyrrolidin-2-yl)methyl)-5-((((S)-3,3-dimethylbutan-2-yl)amino)methyl)-1H-benzo[d]imidazol-2-yl)-5-(difluoromethyl)thiophene-2-carboxamide;2-Thiophenecarboxamide, 5-(difluoromethyl)-N-[1-[[(2R)-1-(1-oxo-2-propen-1-yl)-2-pyrrolidinyl]methyl]-5-[[[(1S)-1,2,2-trimethylpropyl]amino]methyl]-1H-benzimidazol-2-yl]-;N-[(2E)-1-{[(2R)-1-Acryloyl-2-pyrrolidinyl]methyl}-5-({[(2S)-3,3-dimethyl-2-butanyl]amino}methyl)-1,3-dihydro-2H-benzimidazol-2-ylidene]-5-(difluoromethyl)-2-thiophenecarboxamide
CBNumber:
CB73168582
Molecular Formula:
C28H35F2N5O2S
Molecular Weight:
543.67
MDL Number:
MFCD28963888
MOL File:
1575818-46-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:59:54
Product description Number Pack Size Price
PRN694 98.09% CS-0012239 1mg $364
PRN694 98.09% CS-0012239 5mg $921
PRN694 98.09% CS-0012239 10mg $1473
PRN694 98.09% CS-0012239 25mg $2947
PRN694 98.09% CS-0012239 50mg $4712
Request For Quotation

PRN694 Properties

Density 1.29±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 125 mg/mL (229.92 mM)
pka 11.95±0.43(Predicted)
form Solid
color Off-white to light brown
FDA UNII K5IZ54DF9G

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501

PRN694 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0012239 PRN694 98.09% 1575818-46-0 1mg $364 2026-06-04 Buy
ChemScene CS-0012239 PRN694 98.09% 1575818-46-0 5mg $921 2026-06-04 Buy
ChemScene CS-0012239 PRN694 98.09% 1575818-46-0 10mg $1473 2026-06-04 Buy
ChemScene CS-0012239 PRN694 98.09% 1575818-46-0 25mg $2947 2026-06-04 Buy
ChemScene CS-0012239 PRN694 98.09% 1575818-46-0 50mg $4712 2026-06-04 Buy
Product number Packaging Price Buy
CS-0012239 1mg $364 Buy
CS-0012239 5mg $921 Buy
CS-0012239 10mg $1473 Buy
CS-0012239 25mg $2947 Buy
CS-0012239 50mg $4712 Buy

PRN694 Chemical Properties,Uses,Production

Uses

PRN694 is an irreversible, highly selective and potent covalent interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) dual inhibitor with IC50s of 0.3 nM and 1.4 nM, respectively. PRN694 exhibits extended target residence time on ITK and RLK, enabling durable attenuation of effector cells in vitro and in vivo[1].

in vivo

The PRN694 occupancy of ITK is 98, 95, and 54% at 1, 6, and 14 h, respectively. The concentrations of PRN694 in the plasma are 2.8, 0.66, and 0.027 μM at 1, 6, and 14 h, respectively. At 14 h, the plasma level of PRN694 is over 10 fold lower than the IC50 in whole blood. RN694 treatment also results in significantly lower weights relative to vehicle (p<0.05)[1].
Colitis studies show reduced numbers of CD4+ T cells present in the colonic epithelium of PRN694-treated mice compare with controls[2].

References

[1] Zhong Y, et al. Targeting interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) using a novel covalent inhibitor PRN694. J Biol Chem. 2015 Mar 6;290(10):5960-78. DOI:10.1074/jbc.M114.614891
[2] Cho HS, et al. A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression. J Immunol. 2015 Nov 15;195(10):4822-31. DOI:10.4049/jimmunol.1501828

PRN694 Preparation Products And Raw materials

Raw materials

Preparation Products

PRN694 Suppliers

Global( 21)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Career Henan Chemica Co 		+86-0371-86658258 +86-13203830695 laboratory@coreychem.com China 30203 58
Suzhou ARTK Medchem Co., Ltd. 		+86-18168183658 sales1@artkmedchem.com China 39007 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131885 58
Nanjing SynTitan Pharmaceutical Co., Ltd. 025-57027686 17372956142 li_lan@syntitan.com China 9999 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Tachizaki Biomedical Research Center 18014399201 sales@chemlab-tachizaki.com China 2936 58
Shanghai meikai technology co., ltd 021-68689288 15300790979 info@mkbio.com.cn China 9988 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
Suzhou ARTK Medchem Co., Ltd. 		58
Amadis Chemical Company Limited 		58
Nanjing SynTitan Pharmaceutical Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Tachizaki Biomedical Research Center 58
Shanghai meikai technology co., ltd 58

1575818-46-0(PRN694)Related Search:

4-Morpholineacetamide, N-[2-[(4aS,5aR)-5,5-difluoro-1,4,4a,5,5a,6-hexahydro-5a-methylcycloprop[f]indazol-3-yl]-5-methyl-1H-benzimidazol-6-yl]-N,α-dimethyl-, (αS)- [1,1′-Biphenyl]-4-carboxamide, 2′,3′-dichloro-N-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl]- (4aS,5aR)-N-[1-[(R)-[(2R)-1,1-dioxothian-2-yl]-phenylmethyl]pyrazol-4-yl]-5,5-difluoro-5a-methyl-1,4,4a,6-tetrahydrocyclopropa[f]indazole-3-carboxamide FMF-06-098-1 2-Propenamide, N-[2-[[2-[6-(difluoromethyl)-1H-indazol-3-yl]-6-(phenylmethyl)-1H-indol-4-yl]oxy]ethyl]-
(2S)-N-methyl-N-(6-methyl-2-[(4aS,5aR)-5a-methyl-1.4.4a.5.5a,6-hexahydrocyclopropa|f)indazol-3-yl]-lH-benzimidazol-5-yl}-2-(morpholin-4-yl)propanamide

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PRN694 (E)-N-(1-(((R)-1-Acryloylpyrrolidin-2-yl)methyl)-5-((((S)-3,3-dimethylbutan-2-yl)amino)methyl) N-[(2E)-1-{[(2R)-1-Acryloyl-2-pyrrolidinyl]methyl}-5-({[(2S)-3,3-dimethyl-2-butanyl]amino}methyl)-1,3-dihydro-2H-benzimidazol-2-ylidene]-5-(difluoromethyl)-2-thiophenecarboxamide 2-Thiophenecarboxamide, 5-(difluoromethyl)-N-[1-[[(2R)-1-(1-oxo-2-propen-1-yl)-2-pyrrolidinyl]methyl]-5-[[[(1S)-1,2,2-trimethylpropyl]amino]methyl]-1H-benzimidazol-2-yl]- PRN694,PRN-694 N-(1-(((R)-1-Acryloylpyrrolidin-2-yl)methyl)-5-((((S)-3,3-dimethylbutan-2-yl)amino)methyl)-1H-benzo[d]imidazol-2-yl)-5-(difluoromethyl)thiophene-2-carboxamide 1575818-46-0 C28H35F2N5O2S