YM-58790
- CAS No.
- 214558-72-2
- Chemical Name:
- YM-58790
- Synonyms
- YM-58790;YM58790,YM 58790;YM-58790 hydrochloride;[1-[[4-(Methylamino)phenyl]methyl]piperidin-4-yl] N-benzhydrylcarbamate hydrochloride
- CBNumber:
- CB73175605
- Molecular Formula:
- C27H32ClN3O2
- Molecular Weight:
- 466.02
- MDL Number:
- MFCD00865670
- MOL File:
- 214558-72-2.mol
YM-58790 Chemical Properties,Uses,Production
Uses
YM-58790 is a potent antagonist of mAChR. YM-58790 binds M1, M2, M3 with Ki values of 28 nM, 260 nM, and 15 nM. YM-58790 exhibits potent inhibitory activity on bladder pressuer in reflexly-evoked rhythmic contraction in rats[1].
in vivo
YM-58790 (3 mg/kg, i.v.) has no effect on oxotremorine-induced tremor in mice[1].
YM-58790 (6.0 mg/kg; i.v.) shows poor M1 and M2 antagonism effect in vivo on McN-A343-induced pressor in pithed rats, but displays potent efficacy on M3 antagonism with an ED30 value of 0.36 mg/kg (i.v.) and an ID50 value of 2.4 mg/kg (i.v.)[1].
YM-58790 exhibits potent inhibitory activity on bladder pressuer in reflexly-evoked rhythmic contraction, similar to Oxybutynin.html" class="link-product" target="_blank">Oxybutynin (HY-B0267), and has about ten times less inhibitory effect on oxotremorine-induced salivary secretion than oxybutynin in rats[1].
IC 50
mAChR3: 15 nM (Ki); mAChR1: 28 nM (Ki); mAChR2: 260 nM (Ki)
References
[1] Naito R, et al. Selective muscarinic antagonists. I. Synthesis and antimuscarinic properties of 4-piperidyl benzhydrylcarbamate derivatives. Chem Pharm Bull (Tokyo). 1998 Aug;46(8):1274-85. DOI:10.1248/cpb.46.1274
YM-58790 Preparation Products And Raw materials
Raw materials
Preparation Products
YM-58790 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29770 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
| Adooq Bioscience LLC | 400-025-6535 | sales@adooq.cn | China | 6215 | 58 |
| Guangzhou Xinghe Biotechnology Co., Ltd. | 15889822182 | CHINA | 160 | 58 | |
| Guangzhou Baide Biotechnology Co., Ltd. | 18925065404 | CHINA | 168 | 58 |
View Lastest Price from YM-58790 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-21 | YM-58790 hydrochloride
214558-72-2
|
US $324.00-2690.00 / mg | 10g | TargetMol Chemicals Inc. |
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- YM-58790 hydrochloride
214558-72-2
- US $324.00-2690.00 / mg
- TargetMol Chemicals Inc.
