BOC-D-ALA-OME
- CAS No.
- 91103-47-8
- Chemical Name:
- BOC-D-ALA-OME
- Synonyms
- BOC-D-ALANINE METHYL ESTER;methyl (tert-butoxycarbonyl)-D-alaninate;BOC-D-ALA-OME;Boc-D-Ala-OMe 99%;N-(tert-Butoxycarbon;Boc-D-methyl alanine;Boc-
D -Ala-OMe;BOC-D-ALA-OME USP/EP/BP;D-Boc alanine methyl ester;BOC-D-Alanine methyleester
- CBNumber:
- CB7326428
- Molecular Formula:
- C9H17NO4
- Molecular Weight:
- 203.24
- MDL Number:
- MFCD00191865
- MOL File:
- 91103-47-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Boc-D-alanine methyl ester ≥99%(HPLC) | 11831 | 1G | $18.5 |
| Boc-D-alanine methyl ester ≥99%(HPLC) | 11831 | 5G | $30 |
| Boc-D-alanine methyl ester ≥99%(HPLC) | 11831 | 25G | $65 |
| (R)-Methyl 2-((tert-butoxycarbonyl)amino)propanoate >98% | M68795 | 25g | $25 |
| (R)-Methyl 2-((tert-butoxycarbonyl)amino)propanoate >98% | M68795 | 10g | $40 |
| More product size | |||
| Melting point | 34-37 °C(lit.) |
|---|---|
| Boiling point | 341.54°C (rough estimate) |
| Density | 1.03 g/mL at 25 °C(lit.) |
| refractive index | 1.4315 (estimate) |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| pka | 11.21±0.46(Predicted) |
| form | Powder |
| color | White |
| optical activity | [α]20/D +45°, c = 1 in methanol |
| BRN | 4310313 |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C9H17NO4/c1-6(7(11)13-5)10-8(12)14-9(2,3)4/h6H,1-5H3,(H,10,12)/t6-/m1/s1 |
| InChIKey | GJDICGOCZGRDFM-ZCFIWIBFSA-N |
| SMILES | C(OC)(=O)[C@@H](C)NC(OC(C)(C)C)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P362+P364 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2924297099 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
BOC-D-ALA-OME price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Chem-Impex | 11831 | Boc-D-alanine methyl ester ≥99%(HPLC) | 91103-47-8 | 1G | $18.5 | 2026-05-19 | Buy |
| Chem-Impex | 11831 | Boc-D-alanine methyl ester ≥99%(HPLC) | 91103-47-8 | 5G | $30 | 2026-05-19 | Buy |
| Chem-Impex | 11831 | Boc-D-alanine methyl ester ≥99%(HPLC) | 91103-47-8 | 25G | $65 | 2026-05-19 | Buy |
| Synthonix | M68795 | (R)-Methyl 2-((tert-butoxycarbonyl)amino)propanoate >98% | 91103-47-8 | 25g | $25 | 2026-05-06 | Buy |
| Synthonix | M68795 | (R)-Methyl 2-((tert-butoxycarbonyl)amino)propanoate >98% | 91103-47-8 | 10g | $40 | 2026-05-06 | Buy |
BOC-D-ALA-OME Chemical Properties,Uses,Production
Chemical Properties
White powder
Uses
peptide synthesis
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
24424-99-5
14316-06-4
91103-47-8
General procedure for the synthesis of Boc-D-alanine methyl ester from di-tert-butyl dicarbonate and D-alanine methyl ester hydrochloride: di-tert-butyl dicarbonate (11.7 g, 53.7 mmol) was added to an aqueous solution (100 mL) containing D-alanine methyl ester hydrochloride (5 g, 35.8 mmol) and sodium hydrogen carbonate (9.0 g, 107 mmol). The reaction mixture was stirred at room temperature. Upon completion of the reaction, the reaction mixture was extracted with dichloromethane (DCM, 3 x 100 mL), the organic phases were combined and dried over anhydrous magnesium sulfate (MgSO4). The dried organic phase was filtered and concentrated under reduced pressure. Nuclear magnetic resonance (NMR) analysis of the crude product showed the presence of a large amount of unreacted di-tert-butyl dicarbonate. Therefore, the crude product was dissolved in dichloromethane (DCM, 50 mL), treated with N,N-dimethylethylenediamine (5 mL) and stirred for 30 min. Subsequently, the solution was washed with 1 M hydrochloric acid (HCl, 50 mL), and the organic phase was again dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give 5.35 g of Boc-D-alanine methyl ester in 73% yield as a colorless liquid.1H NMR (500 MHz, chloroform-d) δ 5.04 (s,1H), 4.31 (m,1H), 3.73 (s,3H), 1.44 (s,9H), 1.37 (d,J=7.2Hz,3H).
References
[1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985, p. 2299 - 2306
[2] Patent: WO2016/91776, 2016, A1. Location in patent: Page/Page column 387
[3] Heterocycles, 1988, vol. 27, # 9, p. 2077 - 2080
[4] Journal of Organic Chemistry, 1998, vol. 63, # 1, p. 92 - 98
[5] Journal of the Chemical Society - Perkin Transactions 1, 1999, # 4, p. 387 - 398
BOC-D-ALA-OME Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan HongRi Pharma-Tech Co.,Ltd | +8618382028708 | ni@enlaibio.com | China | 1100 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| GenicBio Limited | +86-21-37621270 | service@genicbio.com | CHINA | 991 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29794 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| GL Biochem(Binhai) Ltd. | +86-021-61263370 +8615301650015 | wuqiuyan@glschina.com | China | 2975 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 18895 | 58 |
View Lastest Price from BOC-D-ALA-OME manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-22 | Boc-D-Ala-OMe
91103-47-8
|
US $0.00-0.00 / kg | 1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | |
 |
2021-07-02 | Boc-D-Alanine Methyl Ester
91103-47-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2019-12-24 | BOC-D-ALA-OME
91103-47-8
|
US $1.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- Boc-D-Ala-OMe
91103-47-8
- US $0.00-0.00 / kg
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- Boc-D-Alanine Methyl Ester
91103-47-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- BOC-D-ALA-OME
91103-47-8
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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