ChemicalBook >> CAS DataBase List >>2,4-Difluorotoluene

2,4-Difluorotoluene

2,4-Difluorotoluene structure

CAS No.: 452-76-6

Chemical Name:: 2,4-Difluorotoluene

Synonyms: 2,4-Difluorobenzyl;difluorotoluene;2,4-DIFLUOROTOLUNE;2,4-DIFLUOROTOLUINE;2,4-DIFLUOROTOLUENE;2,4-Difluorotoluene99%;2,4-Difluorotoluene 99%;2,4-Difluorotoluene, 98+%;2.4-Difluoro methyl benzene;1-Methyl-2,4-difluorobenzene

CBNumber:: CB7329212

Molecular Formula:: C7H6F2

Molecular Weight:: 128.12

MDL Number:: MFCD00000332

MOL File:: 452-76-6.mol

Last updated:2026-01-13 11:25:26

Product description	Number	Pack Size	Price
2,4-Difluorotoluene	D2351	10g	$69
2,4-Difluorotoluene	D452568	5g	$75
2,4-Difluorotoluene	D452568	500mg	$45
2,4-Difluorotoluene	D452568	1g	$60
2,4-Difluorotoluene 98%	PC2930	25g	$67
More product size

Request For Quotation

2,4-Difluorotoluene Properties

Melting point	-35 °C
Boiling point	113-117 °C (lit.)
Density	1.12 g/mL at 25 °C (lit.)
refractive index	n20/D 1.449(lit.)
Flash point	59 °F
storage temp.	Sealed in dry,2-8°C
form	Liquid
color	Clear colorless
Specific Gravity	1.120
BRN	1931681
InChI	InChI=1S/C7H6F2/c1-5-2-3-6(8)4-7(5)9/h2-4H,1H3
InChIKey	MPXDAIBTYWGBSL-UHFFFAOYSA-N
SMILES	C1(C)=CC=C(F)C=C1F
CAS DataBase Reference	452-76-6(CAS DataBase Reference)
FDA UNII	RMK2YU8CT4
NIST Chemistry Reference	2,4-Difluorotoluene(452-76-6)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Danger

Hazard statements

H315-H319-H335-H225

Precautionary statements

P210-P233-P240-P241+P242+P243-P280-P303+P361+P353-P403+P235-P501-P261-P305+P351+P338-P405-P501a

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

F,F+

Risk Statements

Safety Statements

16-29-33

RIDADR

UN 1993 3/PG 2

WGK Germany

Hazard Note

Flammable

HazardClass

PackingGroup

HS Code

29039990

Storage Class

3 - Flammable liquids

Hazard Classifications

Flam. Liq. 2

NFPA 704

	3
1		0

2,4-Difluorotoluene price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D2351	2,4-Difluorotoluene	452-76-6	10g	$69	2025-07-31	Buy
TRC	D452568	2,4-Difluorotoluene	452-76-6	5g	$75	2021-12-16	Buy
TRC	D452568	2,4-Difluorotoluene	452-76-6	500mg	$45	2021-12-16	Buy
TRC	D452568	2,4-Difluorotoluene	452-76-6	1g	$60	2021-12-16	Buy
Apolloscientific	PC2930	2,4-Difluorotoluene 98%	452-76-6	25g	$67	2021-12-16	Buy

Product number	Packaging	Price	Buy
D2351	10g	$69	Buy
D452568	5g	$75	Buy
D452568	500mg	$45	Buy
D452568	1g	$60	Buy
PC2930	25g	$67	Buy

2,4-Difluorotoluene Chemical Properties,Uses,Production

Chemical Properties

colorless to light yellow liqui

Uses

2,4-Difluorotoluene was used in the synthesis of new hydrophobic isosteres of pyrimidines and purine nucleosides.

General Description

2,4-Difluorotoluene was synthesized as a nucleotide analog and was incorporated into DNA and undergoes replication by DNA polymerase enzymes.

Synthesis

108-88-3

352-32-9

95-52-3

352-70-5

452-76-6

452-67-5

2927-34-6

The general procedure for the synthesis of p-fluorotoluene, 2-fluorotoluene, 3-fluorotoluene, 2,4-difluorotoluene, 2,5-difluorotoluene, and 1,2-difluoro-4-methylbenzene from toluene is as follows: to a glass reactor fitted with a PTFE-lined magnetic stirring bar attached to a gas scrubbing flask were added toluene derivative (0.95-1.14 mmol), acetonitrile (1-2.5 mL/mmol of toluene derivative), and boron trifluoride ethyl ether complex (1.3-1.6 mmol/mmol of toluene derivative). mmol toluene derivative), acetonitrile (1-2.5 mL/mmol toluene derivative) and boron trifluoride ethyl ether complex (1.3-1.6 mmol/mmol toluene derivative). The reaction mixture was stirred at -25 °C for 10-15 min, followed by the addition of xenon difluoride (1.2-1.3 mmol/mmol toluene derivative) in batches. The reaction system was slowly warmed to 22 °C over 1 h and stirring was continued for 40-60 min. Upon completion of the reaction, hexafluorobenzene was added as an internal standard and samples were taken for 19F NMR analysis (Method B). The reaction mixture was quenched with saturated aqueous sodium bicarbonate and extracted with dichloromethane (1-2 mL). The combined organic phases were dried with anhydrous magnesium sulfate and subsequently analyzed by 19F NMR and GC/MS (Procedure C). The major products are listed in the table and others are shown below (GC/MS data).

References

[1] Russian Journal of Organic Chemistry, 2016, vol. 52, # 10, p. 1400 - 1407
[2] Zh. Org. Khim., 2016, vol. 52, # 10, p. 1412 - 1419,8

2,4-Difluorotoluene Preparation Products And Raw materials

Raw materials

Toluene Xenon difluoride Acetonitrile Boron trifluoride diethyl etherate

Preparation Products

p-Fluorotoluene 2-chloro-1-(2,4-difluoro-5-methylphenyl)ethan-1-one

2,4-Difluorotoluene Suppliers

Global( 297)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Shanghai Worldyang Chemical Co.,Ltd.	+86-021-56795779 +8613651600618	sales@worldyachem.com	China	967	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2176	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Changzhou Carman Chemical Co., Ltd.	15061933924		CHINA	514	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Hi-Tech Chemistry Corp	58
ATK CHEMICAL COMPANY LIMITED	60
Changzhou Ansciep Chemical Co., Ltd.	58
Jinan Carbotang Biotech Co.,Ltd.	58
Shanghai Worldyang Chemical Co.,Ltd.	58
Changzhou Ditong Chemical Co.,Ltd	58
Hubei xin bonus chemical co. LTD	58
Changzhou Carman Chemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 2,4-Difluorotoluene manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-02-02	2,4-Difluorotoluene 452-76-6	US $0.00-0.00 / KG	50mg	99%HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd
	2019-12-26	2,4-Difluorotoluene 452-76-6	US $2.00 / KG	1KG	98%MIN	ASK	Career Henan Chemical Co

2,4-Difluorotoluene
452-76-6
US $0.00-0.00 / KG
99%HPLC
Shaanxi Dideu Medichem Co. Ltd

2,4-Difluorotoluene
452-76-6
US $2.00 / KG
98%MIN
Career Henan Chemical Co

2,4-Difluorotoluene Spectrum

2,4-Difluorotoluene(452-76-6)MS 2,4-Difluorotoluene(452-76-6)¹HNMR 2,4-Difluorotoluene(452-76-6)¹³CNMR 2,4-Difluorotoluene(452-76-6)IR1 2,4-Difluorotoluene(452-76-6)Raman

452-76-6(2,4-Difluorotoluene)Related Search:

Xylene 3-Fluorobenzotrifluoride 2-Methylbenzotrifluoride m-Xylene Tosufloxacin tosylate

o-Xylene Benzotrifluoride Toluene 2,3,4,5,6-PENTAFLUOROBENZOPHENONE DECAFLUOROBENZOPHENONE

2,4-Difluorobenzoyl chloride OCTAFLUOROTOLUENE 2',3',4',5',6'-PENTAFLUOROACETOPHENONE DECAFLUOROBENZHYDROL Pentafluorobenzonitrile

2,3,4,5,6-PENTAFLUOROPHENYLACETIC ACID α-Bromo-2,3,4,5,6-pentafluorotoluene Decafluorobiphenyl

1of4

1-Methyl-2,4-difluorobenzene 2,4-Difluorotoluene, 98% 25GR Benzene, 2,4-difluoro-1-methyl- 2,4-DIFLUOROTOLUENE 2,4-DIFLUOROTOLUINE 2,4-DIFLUORO-1-METHYL-BENZENE 2,4-DIFLUOROTOLUNE 2.4-Difluoro methyl benzene 2,4-Difluorotoluene, 98+% 2,4-Difluorotoluene 99% 2,4-Difluorotoluene99% difluorotoluene 2,4-Difluorobenzyl 1,3-Difluoro-4-methylbenzene 452-76-6 2-76-6 FeC6H3CH3 CH3C6H3F2 Aryl C7 Building Blocks Organic Building Blocks Halogenated Hydrocarbons Halogen toluene Miscellaneous Aryl C7 Halogenated Hydrocarbons Aromatic Hydrocarbons (substituted) & Derivatives Fluorinated benzene series Fluorin-contained toluene series Fluorobenzene