CIS-ENTACAPONE
- CAS No.
- 145195-63-7
- Chemical Name:
- CIS-ENTACAPONE
- Synonyms
- CIS-ENTACAPONE;(Z)-Entacapone;Entacapen impurity A;Entacapone-d10 (cis);Entacapone impurity A;Entacapone impurity A -I;Entacapone EP IMpurity A;Entacapone impurity A CRS;Entacapone Related CoMpound A;Z Entacapone/ EP impurity A/RC A
- CBNumber:
- CB7334326
- Molecular Formula:
- C14H15N3O5
- Molecular Weight:
- 305.29
- MDL Number:
- MFCD00869878
- MOL File:
- 145195-63-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Entacapone impurity A European Pharmacopoeia (EP) Reference Standard | Y0001250 | 10 mg | $127 |
| Entacapone Related Compound A certified reference material, pharmaceutical secondary standard | PHR3444 | 50 mg | $648 |
| Entacapone impurity A | 1235944 | 25mg | $1290 |
| Entacapone impurity A European Pharmacopoeia (EP) Reference Standard | Y0001250 | y0001250 | $89.2 |
| cis-Entacapone ≥98% | 28046 | 1mg | $134 |
| More product size | |||
| Melting point | 142-144°C |
|---|---|
| Boiling point | 526.6±50.0 °C(Predicted) |
| Density | 1.392±0.06 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility | Dichloromethane (Slightly), Methanol (Slightly) |
| pka | 5.15±0.50(Predicted) |
| color | Yellow to Orange |
| Major Application | pharmaceutical |
| InChI | 1S/C14H15N3O5/c1-3-16(4-2)14(20)10(8-15)5-9-6-11(17(21)22)13(19)12(18)7-9/h5-7,18-19H,3-4H2,1-2H3/b10-5- |
| InChIKey | JRURYQJSLYLRLN-YHYXMXQVSA-N |
| SMILES | [N+](=O)([O-])c1c(c(cc(c1)\C=C(/C(=O)N(CC)CC)\C#N)O)O |
| FDA UNII | 4X96VV9HUQ |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| WGK Germany | WGK 3 |
|---|---|
| HS Code | 2926900005 |
| Storage Class | 11 - Combustible Solids |
CIS-ENTACAPONE price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001250 | Entacapone impurity A European Pharmacopoeia (EP) Reference Standard | 145195-63-7 | 10 mg | $127 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR3444 | Entacapone Related Compound A certified reference material, pharmaceutical secondary standard | 145195-63-7 | 50 mg | $648 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1235944 | Entacapone impurity A | 145195-63-7 | 25mg | $1290 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0001250 | Entacapone impurity A European Pharmacopoeia (EP) Reference Standard | 145195-63-7 | y0001250 | $89.2 | 2024-03-01 | Buy |
| Cayman Chemical | 28046 | cis-Entacapone ≥98% | 145195-63-7 | 1mg | $134 | 2026-04-30 | Buy |
CIS-ENTACAPONE Chemical Properties,Uses,Production
Description
cis-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor entacapone . It is also a potential impurity found in commercial preparations of entacapone and a degradant of entacapone formed by UV light exposure.
Chemical Properties
Orange Solid
Uses
cis-Entacapone (Entacapone EP Impurity A) is the (Z)-Isomer of Entacapone polymorphic form B. Antiparkinsonian.
Definition
ChEBI: 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide is a hydroxycinnamic acid.
References
[1] T WIKBERG. Identification of major metabolites of the catechol-O-methyltransferase inhibitor entacapone in rats and humans.[J]. Drug Metabolism and Disposition, 1993, 21 1: 81-92.
[2] S. SARAVANAN R S. METHOD DEVELOPMENT AND VALIDATION FOR DETERMINATION OF IMPURITIES IN DEFERASIROX BY RP-HPLC TECHNIQUE[J]. Journal of Drug Delivery and Therapeutics, 2012, 34 1. DOI: 10.22270/jddt.v2i3.128
[3] NADEJDA SOUKHOVA. Development of characterization methods for entacapone in a pharmaceutical bulk[J]. Journal of pharmaceutical and biomedical analysis, 2011, 54 4: Pages 860-865. DOI: 10.1016/j.jpba.2010.10.019
CIS-ENTACAPONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30227 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| Moxin Chemicals | +86-17320513646 +8617320513646 | anna@molcoo.com | China | 10000 | 58 |
| Sinco Pharmachem (ShenZhen) R&D Co., Ltd. | +undefined18603013401 | jack.lin@sincopharmachem.com | China | 9996 | 58 |
| QUALITY CONTROL SOLUTIONS LTD. | +86-0755-66853366 +86-13670046396 | export03@qcsrm.com | China | 24342 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9815 | 79 |
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