3-FLUORO-4-HYDROXYPHENYLACETIC ACID
- CAS No.
- 458-09-3
- Chemical Name:
- 3-FLUORO-4-HYDROXYPHENYLACETIC ACID
- Synonyms
- 2-(3-fluoro-4-hydroxyphenyl)acetic acid;4-(Carboxymethyl)-2-fluorophenol;3-Fluoro-4-HydroxyphenylaceticAci;3-FLUORO-4-HYDROXYPHENYLACETIC ACID;3-Fluoro-4-hydroxybenzeneacetic acid;Benzeneacetic acid, 3-fluoro-4-hydroxy-;3-Fluoro-4-hydroxyphenylacetic acid,98%;4-(Carboxymethyl)-2-fluorophenol, (3-Fluoro-4-hydroxyphenyl)acetic acid
- CBNumber:
- CB7335893
- Molecular Formula:
- C8H7FO3
- Molecular Weight:
- 170.14
- MDL Number:
- MFCD00004348
- MOL File:
- 458-09-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Fluoro-4-hydroxyphenylacetic acid 98% | 224510 | 1g | $71.2 |
| 3-Fluoro-4-hydroxyphenylacetic acid | FF71107 | 10g | $276.5 |
| 3-Fluoro-4-hydroxyphenylacetic acid | FF71107 | 25g | $518.25 |
| 3-Fluoro-4-hydroxyphenylacetic acid | FF71107 | 50g | $950 |
| 3-Fluoro-4-hydroxyphenylacetic acid | FF71107 | 100g | $1555 |
| More product size | |||
| Melting point | 132-134 °C (lit.) |
|---|---|
| Boiling point | 320.3±27.0 °C(Predicted) |
| Density | 1.423±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 4.30±0.10(Predicted) |
| form | Crystalline Powder |
| color | White to beige |
| InChI | 1S/C8H7FO3/c9-6-3-5(4-8(11)12)1-2-7(6)10/h1-3,10H,4H2,(H,11,12) |
| InChIKey | YRFBZAHYMOSSGX-UHFFFAOYSA-N |
| SMILES | OC(=O)Cc1ccc(O)c(F)c1 |
| CAS DataBase Reference | 458-09-3(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29182900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-FLUORO-4-HYDROXYPHENYLACETIC ACID price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 224510 | 3-Fluoro-4-hydroxyphenylacetic acid 98% | 458-09-3 | 1g | $71.2 | 2023-01-07 | Buy |
| Biosynth | FF71107 | 3-Fluoro-4-hydroxyphenylacetic acid | 458-09-3 | 10g | $276.5 | 2026-06-04 | Buy |
| Biosynth | FF71107 | 3-Fluoro-4-hydroxyphenylacetic acid | 458-09-3 | 25g | $518.25 | 2026-06-04 | Buy |
| Biosynth | FF71107 | 3-Fluoro-4-hydroxyphenylacetic acid | 458-09-3 | 50g | $950 | 2026-06-04 | Buy |
| Biosynth | FF71107 | 3-Fluoro-4-hydroxyphenylacetic acid | 458-09-3 | 100g | $1555 | 2026-06-04 | Buy |
3-FLUORO-4-HYDROXYPHENYLACETIC ACID Chemical Properties,Uses,Production
Chemical Properties
White to beige crystalline powder
Synthesis
452-14-2
458-09-3
General procedure for the synthesis of 3-fluoro-4-hydroxyphenylacetic acid from 3-fluoro-4-methoxyphenylacetic acid: Aluminum chloride (42.8 g, 0.32 mol) was slowly added to 500 mL of toluene solution containing 3-fluoro-4-methoxyphenylacetic acid (45 g, 0.245 mol), and the temperature of the reaction was controlled to be no more than 25 °C. Subsequently, the reaction mixture was heated to reflux for 5 hours. Upon completion of the reaction, 260 mL of 10% hydrochloric acid was added to the cooled solution. The precipitate was collected by filtration and the filtrate was extracted twice with 75 mL of 1,2-dichloroethane. The organic extracts were combined and washed sequentially with 5% sodium hydroxide solution and water. The alkaline washings were combined with the previously collected precipitate and filtered through activated carbon after adjusting the pH to 12 with 5% sodium hydroxide solution. The filtrate was acidified with 50% sulfuric acid and the resulting oil was extracted with ether. The organic phase was dried and the solvent was evaporated to give 3-fluoro-4-hydroxyphenylacetic acid in a yield of 25 g (62% yield). The melting point of the product was 109-111 °C. Mass spectrum (ESI) m/z (relative abundance): 193.0 [M + Na]+.
Purification Methods
Crystallise the acid from water. [Beilstein 10 III 440.]
References
[1] Collection of Czechoslovak Chemical Communications, 1990, vol. 55, # 1, p. 296 - 306
[2] European Journal of Medicinal Chemistry, 2014, vol. 87, p. 508 - 518
[3] Chemische Berichte, 1952, vol. 85, p. 577,580
[4] DRP/DRBP Org.Chem.,
3-FLUORO-4-HYDROXYPHENYLACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14301 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6290 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-17392587031 | 1059@dideu.com | China | 9984 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9897 | 58 |
View Lastest Price from 3-FLUORO-4-HYDROXYPHENYLACETIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-02-22 | 3-Fluoro-4-hydroxyphenylacetic acid
458-09-3
|
1KG | 97.1% | 100 tons | Honest Joy Holdings Limited | ||
 |
2020-01-05 | 3-FLUORO-4-HYDROXYPHENYLACETIC ACID
458-09-3
|
$9.80 | 1KG | 97%-99% | 1kg -1000kg | Career Henan Chemical Co |
-
- 3-Fluoro-4-hydroxyphenylacetic acid
458-09-3
- $0.00
- 97.1%
- Honest Joy Holdings Limited
-
- 3-FLUORO-4-HYDROXYPHENYLACETIC ACID
458-09-3
- $9.80
- 97%-99%
- Career Henan Chemical Co
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