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VU6005649

VU6005649 Structure
VU6005649 structure
CAS No.
2137047-43-7
Chemical Name:
VU6005649
Synonyms
CS-2729;VU6005649;VU-6005649;VU 6005649;VU6005649, 10 mM in DMSO;VU6005649; VU-6005649; VU 6005649;Inhibitor,inhibit,VU6005649,mGluR,Metabotropic glutamate receptors,VU 6005649,VU-6005649;3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine;Pyrazolo[1,5-a]pyrimidine, 3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)-
CBNumber:
CB73364461
Molecular Formula:
C16H12F5N3O
Molecular Weight:
357.28
MDL Number:
MFCD31922705
MOL File:
2137047-43-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-18 10:06:17
Product description Number Pack Size Price
VU6005649 ≥98% 43138 5mg $76
VU6005649 ≥98% 43138 10mg $121
VU6005649 ≥98% 43138 25mg $228
VU6005649 ≥98% 43138 50mg $380
VU 6005649 ≥98% 468780 10mg $502
Request For Quotation

VU6005649 Properties

Density 1.43±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka -1.73±0.30(Predicted)
form Solid
color Light yellow to yellow
InChI InChI=1S/C16H12F5N3O/c1-7-6-11(16(19,20)21)24-15(22-7)12(8(2)23-24)9-4-5-10(25-3)14(18)13(9)17/h4-6H,1-3H3
InChIKey NYBZCKAQIIPSDS-UHFFFAOYSA-N
SMILES C12=C(C3=CC=C(OC)C(F)=C3F)C(C)=NN1C(C(F)(F)F)=CC(C)=N2

VU6005649 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 43138 VU6005649 ≥98% 2137047-43-7 5mg $76 2026-04-30 Buy
Cayman Chemical 43138 VU6005649 ≥98% 2137047-43-7 10mg $121 2026-04-30 Buy
Cayman Chemical 43138 VU6005649 ≥98% 2137047-43-7 25mg $228 2026-04-30 Buy
Cayman Chemical 43138 VU6005649 ≥98% 2137047-43-7 50mg $380 2026-04-30 Buy
Usbiological 468780 VU 6005649 ≥98% 2137047-43-7 10mg $502 2026-06-03 Buy
Product number Packaging Price Buy
43138 5mg $76 Buy
43138 10mg $121 Buy
43138 25mg $228 Buy
43138 50mg $380 Buy
468780 10mg $502 Buy

VU6005649 Chemical Properties,Uses,Production

Uses

VU 6005649, is a novel mGlu7/8 receptor agonist with excellent CNS penetration (Kp 1.9-5.8 and Kp,uu 0.4-1.4).

in vivo

When VU6005649 (compound 9f) is dosed at 30 mg/kg IP in 10% Tween 80/H2O (0.75 mg/kg. s.c. amphetamine), no efficacy is observed in this assay. VU6005649 shows modest but significant pro-cognitive effects on associative learning in wild-type mice and the first example of efficacy of an mGlu7/8 positive allosteric modulator (PAM) in this model[1].

IC 50

mGlu7 Receptor: 0.65 μM (EC50); mGlu8 Receptor: 2.6 μM (EC50)

storage

Store at -20°C

VU6005649 Preparation Products And Raw materials

Raw materials

Preparation Products

VU6005649 Suppliers

Global( 45)Suppliers
Supplier Tel Email Country ProdList Advantage
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131956 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32467 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39040 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8615965530500 nickzhang@hangyubiotech.com China 9945 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
NANJING YINGWEN BIOTECHNOLOGY CO LTD 		+8613382787392 sales@aeechem.com China 10002 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4849 55
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2790 55
Supplier Advantage
Amadis Chemical Company Limited
58
TargetMol Chemicals Inc. 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Aladdin Scientific 		58
NANJING YINGWEN BIOTECHNOLOGY CO LTD 		58
Shanghai Boyle Chemical Co., Ltd. 55
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Beckham Medical Technology Co., Ltd 55

View Lastest Price from VU6005649 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
VU6005649 pictures 2026-05-16 VU6005649
2137047-43-7
 $37.00-121.00 99.87% 10g TargetMol Chemicals Inc.
VU6005649 pictures 2026-05-16 VU6005649
2137047-43-7
 $37.00-121.00 99.87% 10g TargetMol Chemicals Inc.
  • VU6005649 pictures
  • VU6005649
    2137047-43-7
  • $37.00-121.00
  • 99.87%
  • TargetMol Chemicals Inc.
  • VU6005649 pictures
  • VU6005649
    2137047-43-7
  • $37.00-121.00
  • 99.87%
  • TargetMol Chemicals Inc.

VU6005649 Spectrum

VU6005649(2137047-43-7)1HNMR

2137047-43-7(VU6005649)Related Search:

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VU6005649 VU-6005649;VU 6005649 VU6005649; VU-6005649; VU 6005649 CS-2729 Pyrazolo[1,5-a]pyrimidine, 3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)- Inhibitor,inhibit,VU6005649,mGluR,Metabotropic glutamate receptors,VU 6005649,VU-6005649 3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine VU6005649, 10 mM in DMSO 2137047-43-7 C16H12F5N3O