Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Ningetinib

Ningetinib

Ningetinib Structure
Ningetinib structure
CAS No.
1394820-69-9
Chemical Name:
Ningetinib
Synonyms
CS-2653;CT053PTSA;Ningetinib;Ningetinib(free base);Ningetinib, 10 mM in DMSO;Ningetinib-Tosylate(free base);Vascular endothelial growth factor receptor,inhibit,c-Met/HGFR,TAM Receptor,Mer,Tyro3,VEGFR,Ningetinib,Axl,Inhibitor;N-(3-fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide;1H-Pyrazole-4-carboxamide, N-[3-fluoro-4-[[7-(2-hydroxy-2-methylpropoxy)-4-quinolinyl]oxy]phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-
CBNumber:
CB73367255
Molecular Formula:
C31H29FN4O5
Molecular Weight:
556.58
MDL Number:
MFCD28502048
MOL File:
1394820-69-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-02 09:21:32
Product description Number Pack Size Price
Ningetinib ≥98% 25233 1mg $53
Ningetinib ≥98% 25233 5mg $205
Ningetinib ≥98% 25233 10mg $332
Ningetinib ≥98% 25233 25mg $574
Ningetinib ≥98% 25233 1mg $48
Request For Quotation

Ningetinib Properties

Density 1.348±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 15 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 2 mg/ml
form A crystalline solid
pka 11.00±0.70(Predicted)
color White to off-white
FDA UNII PW3Q92Z6A4

Ningetinib price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 25233 Ningetinib ≥98% 1394820-69-9 1mg $53 2026-04-30 Buy
Cayman Chemical 25233 Ningetinib ≥98% 1394820-69-9 5mg $205 2026-04-30 Buy
Cayman Chemical 25233 Ningetinib ≥98% 1394820-69-9 10mg $332 2026-04-30 Buy
Cayman Chemical 25233 Ningetinib ≥98% 1394820-69-9 25mg $574 2026-04-30 Buy
Cayman Chemical 25233 Ningetinib ≥98% 1394820-69-9 1mg $48 2024-03-01 Buy
Product number Packaging Price Buy
25233 1mg $53 Buy
25233 5mg $205 Buy
25233 10mg $332 Buy
25233 25mg $574 Buy
25233 1mg $48 Buy

Ningetinib Chemical Properties,Uses,Production

Uses

Ningetinib, is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively.

in vivo

When single dosed orally (3 mg/kg) to U87MG tumor-bearing nude mice, Ningetinib (CT053PTSA) potently inhibits the phosphorylation of c-Met and its downstream signaling kinases AKT and ERK1/2 for up to 6 hours in tumor tissues. In orthotopic U87MG human glioblastoma xenograft model, Ningetinib prolongs the median survival time (MST) and yields significant increase in life-span value (ILS=32%, p=0.003) at an oral dose of 20 mg/kg/day (dosed 21 days) versus the vehicle-treated group[1].

IC 50

VEGFR2: 1.9 nM (IC50); Axl

Ningetinib Preparation Products And Raw materials

Raw materials

Preparation Products

Ningetinib Suppliers

Global( 50)Suppliers
Supplier Tel Email Country ProdList Advantage
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39040 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131956 58
ChemShuttle, Inc. 0510-83588313-811 18800520310 sales@chemshuttle.com China 2999 62
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9520 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3504 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4849 55
Supplier Advantage
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
ChemShuttle, Inc. 62
BOC Sciences 65
Shanghai Topbiochem Technology Co., Ltd 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55

View Lastest Price from Ningetinib manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ningetinib pictures 2026-06-01 Ningetinib
1394820-69-9
 $65.00-188.00 99.98% 10g TargetMol Chemicals Inc.
  • Ningetinib pictures
  • Ningetinib
    1394820-69-9
  • $65.00-188.00
  • 99.98%
  • TargetMol Chemicals Inc.

Ningetinib Spectrum

Ningetinib(1394820-69-9)1HNMR
CS-2653 Ningetinib-Tosylate(free base) Ningetinib Ningetinib(free base) CT053PTSA 1H-Pyrazole-4-carboxamide, N-[3-fluoro-4-[[7-(2-hydroxy-2-methylpropoxy)-4-quinolinyl]oxy]phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl- N-(3-fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide Vascular endothelial growth factor receptor,inhibit,c-Met/HGFR,TAM Receptor,Mer,Tyro3,VEGFR,Ningetinib,Axl,Inhibitor Ningetinib, 10 mM in DMSO 1394820-69-9