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Levofloxacin carboxylic acid

Levofloxacin carboxylic acid structure

CAS No.: 100986-89-8

Chemical Name:: Levofloxacin carboxylic acid

Synonyms: Levofloxacin Related CoMpound B;8,9-difluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid;S-(-)-9,10-DIFLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO-[1,2,3-DE] [1,4]-BENZOXAZINE-6-CARBOXYLIC ACID;(S)-(-)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid 97%;7H-Pyrido[1;oxacin Q-Acid;10-difluoro-2;Levofloxacin-8;Levofloxacin USP RC B;LevofloxacinQ-Acid>

CBNumber:: CB7337190

Molecular Formula:: C13H9F2NO4

Molecular Weight:: 281.21

MDL Number:: MFCD04039905

MOL File:: 100986-89-8.mol

MSDS File:: SDS

Last updated:2026-01-13 11:25:38

Product description	Number	Pack Size	Price
Levofloxacin Related Compound B Pharmaceutical Secondary Standard; Certified Reference Material	PHR2229	100mg	$641
(S)-(?)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid 97%	570877	5g	$62.9
Levofloxacin Related Compound B United States Pharmacopeia (USP) Reference Standard	1362125	35mg	$1290
Levofloxacin Q-Acid >98.0%(HPLC)(T)	L0238	1g	$61
Levofloxacin Q-Acid >98.0%(HPLC)(T)	L0238	5g	$184
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Levofloxacin carboxylic acid Properties

Melting point	>300 °C (lit.)
Boiling point	459.2±45.0 °C(Predicted)
Density	1.61±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly)
pka	4.87±0.40(Predicted)
color	White
optical activity	[α]20/D -64°, c = 1% in DMSO
InChI	InChI=1S/C13H9F2NO4/c1-5-4-20-12-9(15)8(14)2-6-10(12)16(5)3-7(11(6)17)13(18)19/h2-3,5H,4H2,1H3,(H,18,19)/t5-/m0/s1
InChIKey	NVKWWNNJFKZNJO-YFKPBYRVSA-N
SMILES	O1C2=C(F)C(F)=CC3C(=O)C(C(O)=O)=CN(C2=3)[C@@H](C)C1
CAS DataBase Reference	100986-89-8(CAS DataBase Reference)
FDA UNII	08GT8FY84E
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38-36/37/3

Safety Statements

26-36

WGK Germany

HS Code

29349990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

Levofloxacin carboxylic acid price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR2229	Levofloxacin Related Compound B Pharmaceutical Secondary Standard; Certified Reference Material	100986-89-8	100mg	$641	2026-03-19	Buy
Sigma-Aldrich	570877	(S)-(?)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid 97%	100986-89-8	5g	$62.9	2026-03-19	Buy
Sigma-Aldrich	1362125	Levofloxacin Related Compound B United States Pharmacopeia (USP) Reference Standard	100986-89-8	35mg	$1290	2026-03-19	Buy
TCI Chemical	L0238	Levofloxacin Q-Acid >98.0%(HPLC)(T)	100986-89-8	1g	$61	2026-03-19	Buy
TCI Chemical	L0238	Levofloxacin Q-Acid >98.0%(HPLC)(T)	100986-89-8	5g	$184	2026-03-19	Buy

Product number	Packaging	Price	Buy
PHR2229	100mg	$641	Buy
570877	5g	$62.9	Buy
1362125	35mg	$1290	Buy
L0238	1g	$61	Buy
L0238	5g	$184	Buy

Levofloxacin carboxylic acid Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Levofloxacin intermediate.

Definition

ChEBI: Ofloxacin impurity a is a member of quinolines.

Synthesis

Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate

106939-34-8

100986-89-8

Levofloxacin carboxylic acid was synthesized using ethyl (S)-9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate as starting material in the following steps: 1. to the residue after recovery of DMF was added acetic acid followed by 65 mL of water at room temperature and mixed with stirring. 2. sulfuric acid was slowly added dropwise, and when the dropwise addition was complete, it was heated to reflux and kept at reflux for 1 hour. 3. upon completion of the reaction, cooled to room temperature and subjected to filtration. 4. The filter cake was washed with 65 mL of water and subsequently dried to give 43.98 g of levodicyclic acid, the content of which was determined to be 96.22%. 5. The acetic acid was spun back through acetic acid and spun to dryness. 6. The filtrate was washed with water and filtered again to give 4.81 g of levulinic acid at 61.28%. 7. The recycled water and acetic acid can be recycled separately to minimize waste discharge and reduce raw material costs. 8. For the synthesis of tetrafluorobenzoyl chloride, the total yield after four steps was 87%.

References

[1] Patent: EP368410, 1990, A3
[2] Chemical and pharmaceutical bulletin, 1987, vol. 35, # 5, p. 1896 - 1902
[3] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 23, p. 4213 - 4216
[4] Patent: WO2006/48889, 2006, A1. Location in patent: Page/Page column 18
[5] Patent: US4985557, 1991, A

Levofloxacin carboxylic acid synthesis

Synthesis of Levofloxacin carboxylic acid from Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate

Levofloxacin carboxylic acid Preparation Products And Raw materials

Raw materials

Levofloxacin Impurity 18 2,3,4,5-Tetrafluorobenzoyl chloride Levofloxacin Tetrafluoro Impurity 1 ethyl (S)-6,7,8-trifluoro-1-(1-hydroxypropan-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate Levofloxacin Tetrafluoro Impurity 2

Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Ethyl 2,3,4,5-tetrafluorobenzoyl acetate Benzenepropanoic acid, α-[[[2-(acetyloxy)-1-methylethyl]amino]methylene]-2,3,4,5-tetrafluoro-β-oxo-, ethyl ester, [S-(E)]- (9CI) Diethyl ether N,N-Dimethylformamide

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Preparation Products

Levofloxacin carboxylic acid Suppliers

Global( 397)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Hehua Chemical Co.，Ltd	+86-15800509834 +86-15800509834	sales@hehuachemical.com	China	121	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21592	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29823	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2176	58

Supplier	Advantage
Shanghai Hehua Chemical Co.，Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Henan Bao Enluo International TradeCo.，LTD	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Changzhou Ditong Chemical Co.,Ltd	58

View Lastest Price from Levofloxacin carboxylic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-14	Levofloxacin carboxylic acid 100986-89-8	US $0.00-0.00 / Kg/Drum	1KG	98.5%min	10 TONS	WUHAN FORTUNA CHEMICAL CO., LTD
2026-03-20	Levofloxacin carboxylic acid 100986-89-8	US $10.00 / KG	1KG	99%	5tons	Hebei Chuanghai Biotechnology Co., Ltd
2025-11-18	LEVOFLOXACIN ACID USP/EP/BP	US $1.10 / g	1g	99.9%	100 Tons min	Dideu Industries Group Limited

Levofloxacin carboxylic acid
100986-89-8
US $0.00-0.00 / Kg/Drum
98.5%min
WUHAN FORTUNA CHEMICAL CO., LTD

Levofloxacin carboxylic acid
100986-89-8
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

LEVOFLOXACIN ACID USP/EP/BP
US $1.10 / g
99.9%
Dideu Industries Group Limited

Levofloxacin carboxylic acid Spectrum

Levofloxacin carboxylic acid(100986-89-8)¹HNMR

100986-89-8(Levofloxacin carboxylic acid)Related Search:

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Thiophanate-methyl Citric acid METSULFURON METHYL

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Levefluorocarboxylic Acid Levofloxacin Related Compound B (35 mg) ((S)-9,10,difluro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid) Levo Q Acid(oxa-2,3 dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacid,9,10-difluoro-2,3-dihydro-3-Methyl-7-oxo-,(3S)- (S)-(-)-9,10-Difluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 97+% (3S)-9,10-Difluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid (S)-(-)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxadine-6-carboxylic Acid Levofloxacin USP Related CoMpound B (EP IMpC) Levofloxacin Difluoro Carboxylic Acid (S)-9,10-difluoro-3-Methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid (S)-(-)-9,10-Difluoro-3-Methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 97+% Levofloxacin Related Compound B (35 mg) ((S)-9,10,difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid) (S)-(-)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid 97% S-(-)-9,10-DIFLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO-[1, Levofloxacin USP RC B (S)-9,10-Difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic a (-)-9,10-DIFLUORO-3(S)-METHYL-7-OXO-2,3-DIHYDRO-7H-PYRIDO (1,2,3-DE)-1,4-BENZOXAZINE-6-CARBOXYLIC ACID 8,9-difluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid LEVOFLUOROCARBOXYLIC ACID S(-)-9,10-DIFL-2,3-DIHYDRO-3-ME-7H-PYRI& (-)-9,10-DIFLUORO-3(S)-METHYL-7-OXO-2,3-DIHYDRO-7H- PYRIDO (1,2,3-DE)-1,4-BENZOXAZINE-6-CARBOXYLIC ACID S-(-)-9,10-DIFLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO-[1,2,3-DE][1,4]-BENZOXAZINE-6-CARBOXYLIC ACID 9,10-Difluoro-3(S)-methyl-7-oxo-2,3-dihyd 9,10-DIFLUORO-2,3-DIHYDRO-3-(S)-METHYL-7-OXO-7H-PY S-(-)-9,10-DIFLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO-[1,2,3-DE] [1,4]-BENZOXAZINE-6-CARBOXYLIC ACID 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-(3S)-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid Levofloxacin carboxylic acid (-)-9,10-DIFLUORO-3(S)-METHL-7-OXO-2,3-DIHYDRO-7H-PRYIDO[1,2,3-DE]1,2-BENZOX-AZINE-6-CARBOXYLICACID Levofloxacin EP Impurity C (S)-9,10,difluro-3-Methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid Levofloxacin Carboxylic Acid (Levofloxacin Difluoro IMpurity) 9,10-DIFLUORO-3-(S)-METHYL-7-OXO Levofloxacin Related Compound B(USP) Levofloxacin Impurity H Levofloxacin ImpurityⅡ:LevofloxacinImpurity A{ (3RS)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid} Ofloxacin ImpurityⅠ(Impurity A) Levofloxacin-8 Levofloxacin?EP Impurity F LevofloxacinQ-Acid> oxacin Q-Acid Levofloxacin EP Impurity F (Levofloxacin Related Compound B) Levofloxacin carboxylic acid USP/EP/BP LEVOFLOXACIN ACID USP/EP/BP Levofloxacin carboxylic acidr USP Levofloxacin Related Compound B Levofloxacin Q-acid (Levofloxacin Impurity) Levofloxacin EP Impurity F/ Levofloxacin Related Compound B (Levofloxacin Difluoro Carboxylic Acid) Levofloxacin USP RC B/ Q Acid Levofloxacin Carboxylic Acid833 (S)-(?)-9,1-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid Levofloxacin Related Compound B (G0M041) Levofloxacin Related Compound B ((S)-9,10,difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1 (1362125) (3S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Levoxyfluorocarboxylic acid Levofloxacin Hemihydrate Impurity F Levofloxacin Hemihydrate EP Impurity F Antofloxacin impurity 2 Levofloxacin Impurity 3 (Levofloxacin EP Impurity F)