Atropine sulfate monohydrate
- CAS No.
- 5908-99-6
- Chemical Name:
- Atropine sulfate monohydrate
- Synonyms
- ATRAZINE;HYOSCYAMINE SULFATE;ATROPINE SULPHATE MONOHYDRATE;α-(hydroxymethyl)-benzeneacetic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester sulfate, hydrate (2:1:1);Atropt;Atropsiol;TROPINI SULFAS;AtropineSulfat;ATROPINI SULFAS;atropiniumsulfat
- CBNumber:
- CB7339477
- Molecular Formula:
- C17H25NO7S
- Molecular Weight:
- 387.45
- MDL Number:
- MFCD00074815
- MOL File:
- 5908-99-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 189-192 °C (A)(lit.) |
|---|---|
| alpha | -0.6 º (per USP 25 ºC) |
| storage temp. | Poison room |
| solubility | H2O: soluble2.5g/mL (stable for several days at 4°C.) |
| form | Powder |
| color | white |
| Water Solubility | soluble |
| Sensitive | Light Sensitive |
| Merck | 14,875 |
| BRN | 6109275 |
| Stability | Hygroscopic |
| InChI | InChI=1/C17H23NO3.H2O4S/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4/h2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4)/t13-,14+,15+,16; |
| InChIKey | VJFQPODMEGSXHC-RIMUKSHENA-N |
| SMILES | O([C@@H]1C[C@@H]2CC[C@@H](N2C)C1)C(=O)C(C1C=CC=CC=1)CO.S(O)(O)(=O)=O |&1:1,3,6,r| |
| LogP | 2.137 (est) |
| CAS DataBase Reference | 5908-99-6(CAS DataBase Reference) |
| FDA 21 CFR | 310.545 |
| FDA UNII | 03J5ZE7KA5 |
| UNSPSC Code | 12352210 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H330 | |||||||||
| Precautionary statements | P301+P310+P330-P304+P340+P310 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 26/28-43-36/37/38 | |||||||||
| Safety Statements | 23-45-36/37/39-26-1-25 | |||||||||
| RIDADR | UN 1544 6.1/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | CK2455000 | |||||||||
| F | 3-8-10 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29399900 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
|||||||||
| Hazard Classifications | Acute Tox. 2 Inhalation Acute Tox. 2 Oral |
|||||||||
| NFPA 704 |
|
Atropine sulfate monohydrate price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A0257 | Atropine sulfate salt monohydrate ≥97% (TLC), crystalline | 5908-99-6 | 5g | $121 | 2026-04-30 | Buy |
| Sigma-Aldrich | BP023 | Atropine sulfate British Pharmacopoeia (BP) Reference Standard | 5908-99-6 | 200MG | $354 | 2026-04-30 | Buy |
| Sigma-Aldrich | A1400000 | Atropine sulfate European Pharmacopoeia (EP) Reference Standard | 5908-99-6 | 20 mg | $175 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1045009 | Atropine sulfate United States Pharmacopeia (USP) Reference Standard | 5908-99-6 | 500mg | $501 | 2026-04-30 | Buy |
| Sigma-Aldrich | H1600000 | Hyoscyamine sulfate European Pharmacopoeia (EP) Reference Standard | 80 mg | $254 | 2026-03-19 | Buy |
Atropine sulfate monohydrate Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Uses
Atropine sulfate is mydriatic; antispasmodic; used in preanesthetic medication.
Uses
Anticholinergic;Muscarinic antagonist
Uses
mydriatic and anticholinergie agent in ophthalmie preparations and pre-anesthetie medications; antidote to organophosphous insecticides
Application
Atropine sulfate monohydrate is an alkaloid derived from belladonna, a cholinergic receptor antagonist drug, which has been shown to be a competitive non-selective antagonist of central and peripheral mAChR M (muscarinic acetylcholine receptor). It can be used in the treatment of cardiac arrhythmias. Atropine Sulfate is also used as a pharmaceutical reference standard for a variety of analytical applications.
Application
brand name
Atrophate [Veterinary] (Schering-Plough Animal Health); Atropisol (Ciba Vision, US Ophthalmics); Isopto Atropine (Alcon).
General Description
Atropine is isolated from Atropa belladonna, Datura stramonium and Mandragora officinarum. It is a tertiary amine, which acts as a cholinergic receptor antagonist.
Biological Activity
atropine is a competitive antagonist of muscarinic acetylcholine receptor with ic50 values of 2.22±0.60nm, 4.32±1.63nm, 4.16±1.04nm, 2.38±1.07nm and 3.39±1.16nm for m1, m2, m3, m4 and m5, respectively [1].atropine is an antimuscarinic agent and has shown the pharmacological effects because of binding to muscarinic acetylcholine receptors. atropine, the orthosteric antagonist, has been reported to compete with [3h]-nms for all muscarinic subtypes with a potency consistent with the high affinities at the machr subtypes. the ki values are 1.27±0.36nm, 3.24±1.16nm, 2.21±0.53nm, 0.77±0.43nm and 2.84±0.84nm, respectively [1, 2, 3].
References
[1] lebois ep1, bridges tm, lewis lm, dawson es, kane as, xiang z, jadhav sb, yin h, kennedy jp, meiler j, niswender cm, jones ck, conn pj, weaver cd, lindsley cw. discovery and characterization of novel subtype-selective allosteric agonists for the investigation of m(1) receptor function in the central nervous system.acs chem neurosci. 2010;1(2):104-121.
[2] busch h, allen h, anderson dc.effects of atropine and carbachol on labeling of protein fractions of mouse pancreas in vitro.j pharmacol exp ther. 1959 nov; 127:200-4.
[3] feron o1, smith tw, michel t, kelly ra.dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. j biol chem. 1997 jul 11; 272(28):17744-8.
Atropine sulfate monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| WUHAN MEIAN BIOMEDICINE TECHNOLOGY Co., Ltd， | 15377551262 | 180953430@qq.com | China | 165 | 58 |
| Jiangsu Rongshuo Pharmaceutical Co., Ltd | 0000-15105138935 15105138935 | 2622104407@qq.com | China | 99 | 58 |
| Wuhan Yuqing Jiaheng Pharmaceutical Co., Ltd | 027-83855382 15926260338 | 15926260338@163.com | China | 979 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
View Lastest Price from Atropine sulfate monohydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Belladonna Extract | 1kg | 12%; 40% HPLC | Changsha Staherb Natural Ingredients Co., Ltd. | |||
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2026-09-11 | Atropine sulfate monohydrate
5908-99-6
|
1kg | ≥98% HPLC | 1000kg | Changsha Staherb Natural Ingredients Co., Ltd. | ||
 |
2026-09-11 | Atropine sulfate monohydrate
5908-99-6
|
1KG | 98.5%~101.0%; USP34 | 2000kg/month | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Belladonna Extract
- 12%; 40% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Atropine sulfate monohydrate
5908-99-6
- ≥98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Atropine sulfate monohydrate
5908-99-6
- $0.00
- 98.5%~101.0%; USP34
- WUHAN FORTUNA CHEMICAL CO., LTD
