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N-[(2S)-4-[3-(2-aminocyclopropyl)phenoxy]-1-(benzylamino)-1-oxobutan-2-yl]benzamide

N-[(2S)-4-[3-(2-aminocyclopropyl)phenoxy]-1-(benzylamino)-1-oxobutan-2-yl]benzamide structure

CAS No.: 1196119-03-5

Chemical Name:: N-[(2S)-4-[3-(2-aminocyclopropyl)phenoxy]-1-(benzylamino)-1-oxobutan-2-yl]benzamide

Synonyms: p94;NCL1;LGMD2;CANP3;LGMD2A;CANPL3;N-((S)-1-(benzylcarbamoyl)-3-(3-(2-aminocyclopropyl)phenoxy)propyl)benzamide;N-[(2S)-4-[3-(2-aminocyclopropyl)phenoxy]-1-(benzylamino)-1-oxobutan-2-yl]benzamide

CBNumber:: CB73439446

Molecular Formula:: C27H29N3O3

Molecular Weight:: 443.54

MDL Number:: MFCD22124714

MOL File:: 1196119-03-5.mol

Last updated:2025-04-18 09:52:46

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N-[(2S)-4-[3-(2-aminocyclopropyl)phenoxy]-1-(benzylamino)-1-oxobutan-2-yl]benzamide Properties

Boiling point	754.846±60.00 °C(Press: 760.00 Torr)(predicted)
Density	1.209±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka	12.848±0.46(predicted)

N-[(2S)-4-[3-(2-aminocyclopropyl)phenoxy]-1-(benzylamino)-1-oxobutan-2-yl]benzamide Chemical Properties, Uses, Production

Uses

NCL1 is a phenylcyclopropylamine (PCPA)-based Lysine-specific demethylase 1 (LSD1) inhibitor. NCL1 selectively inhibits LSD1 in preference to LSD2, with IC50 values of 2.5 and 26 μM for LSD1 and LSD2, respectively[1].

IC 50

LSD1: 2.5 ± 0.5 μM (IC₅₀)

References

[1] Kakizawa T, et al. Evaluation of phenylcyclopropylamine compounds by enzymatic assay of lysine-specific demethylase 2 in the presence of NPAC peptide. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1193-5. DOI:10.1016/j.bmcl.2016.01.036

N-[(2S)-4-[3-(2-aminocyclopropyl)phenoxy]-1-(benzylamino)-1-oxobutan-2-yl]benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-[(2S)-4-[3-(2-aminocyclopropyl)phenoxy]-1-(benzylamino)-1-oxobutan-2-yl]benzamide Suppliers

Global Suppliers ( 3)

Supplier	Tel	Email	Country	ProdList	Advantage
RR Scientific LLC	+86-13917743231	sales@rrscientific.com	United States	878	58
R.R Scientific, LLC.	15010167677	zhiyuu1218@163.com	China	876	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
RR Scientific LLC	58
R.R Scientific, LLC.	58
TargetMol Chemicals Inc.	58

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N-[(2S)-4-[3-(2-aminocyclopropyl)phenoxy]-1-(benzylamino)-1-oxobutan-2-yl]benzamide N-((S)-1-(benzylcarbamoyl)-3-(3-(2-aminocyclopropyl)phenoxy)propyl)benzamide NCL1 CANP3 CANPL3 LGMD2 LGMD2A p94 1196119-03-5