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3,5-Dichlorobenzonitrile

3,5-Dichlorobenzonitrile structure

CAS No.: 6575-00-4

Chemical Name:: 3,5-Dichlorobenzonitrile

Synonyms: 3,5-Dichlorobenzonit;3,5-DICHLOROBENZONITRILE;3,5-dichlorobenzenenitrile;3,5-Dichlorobenzonitrile>Benzonitrile, 3,5-dichloro-;3,5-Dichlorobenzonitrile 97%;3,5-Dichlorobenzonitrile,97%;13C6]-3,5-Dichlorobenzonitrile;3,5-Dichlorobenzenecarbonitrile;6-chloro-1,3-diethylpyrimidine-2,4-dione

CBNumber:: CB7344152

Molecular Formula:: C7H3Cl2N

Molecular Weight:: 172.01

MDL Number:: MFCD00001800

MOL File:: 6575-00-4.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:53

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3,5-Dichlorobenzonitrile Properties

Melting point	64-66 °C (lit.)
Boiling point	283.76°C (rough estimate)
Density	1.4980 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform, Methanol (Slightly)
form	Crystalline Powder
color	White to beige-brownish
BRN	2207019
InChI	InChI=1S/C7H3Cl2N/c8-6-1-5(4-10)2-7(9)3-6/h1-3H
InChIKey	PUJSUOGJGIECFQ-UHFFFAOYSA-N
SMILES	C(#N)C1=CC(Cl)=CC(Cl)=C1
CAS DataBase Reference	6575-00-4(CAS DataBase Reference)
FDA UNII	EY25KS4R7X
NIST Chemistry Reference	3,5-Dichlorobenzonitrile(6575-00-4)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS07

Signal word

Warning

Hazard statements

H301+H311+H331-H302-H312-H331-H302+H312+H332-H315-H319-H335

Precautionary statements

P304+P340-P501a-P261-P280-P305+P351+P338-P264-P270-P271-P301+P310+P330-P302+P352+P312+P361+P364-P304+P340+P311-P305+P351+P338+P337+P313-P403+P233-P405-P501

Hazard Codes

Xn,T,Xi

Risk Statements

20/21/22-36/37/38

Safety Statements

26-37/39-36/37/39-22-36-36/37-9

RIDADR

3276

WGK Germany

Hazard Note

Irritant/Toxic

TSCA

HazardClass

6.1

PackingGroup

III

HS Code

29269090

NFPA 704

	1
2		0

3,5-Dichlorobenzonitrile price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	139394	3,5-Dichlorobenzonitrile 97%	6575-00-4	5g	$53.1	2023-01-07	Buy
TCI Chemical	D3261	3,5-Dichlorobenzonitrile >98.0%(GC)	6575-00-4	5g	$38	2025-07-31	Buy
TCI Chemical	D3261	3,5-Dichlorobenzonitrile >98.0%(GC)	6575-00-4	25g	$113	2025-07-31	Buy
TRC	D436528	3,5-Dichlorobenzonitrile	6575-00-4	1g	$50	2021-12-16	Buy
SynQuest Laboratories	3637-5-Z0	3,5-Dichlorobenzonitrile	6575-00-4	25g	$104	2021-12-16	Buy

Product number	Packaging	Price	Buy
139394	5g	$53.1	Buy
D3261	5g	$38	Buy
D3261	25g	$113	Buy
D436528	1g	$50	Buy
3637-5-Z0	25g	$104	Buy

3,5-Dichlorobenzonitrile Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powder

Uses

3,5-Dichlorobenzonitrile was used as internal standard during the programmed temperature vaporization-GC-MS determination of dichlobenil and 2,6-dichlorobenzamide in onions.

Synthesis

19752-55-7

6575-00-4

General procedure for the synthesis of 3,5-dichlorobenzonitrile from 3,5-dichloro-1-bromobenzene: iPrMgCl (2M in THF, 4.1 mL) and THF (5 mL) were added to a flask containing dry LiCl (0.35 g, 8.24 mmol) at 15 °C. After stirring for 15 min, a solution of 3,5-dichloro-1-bromobenzene (1.46 g, 8.03 mmol) in THF (1 mL) was slowly added to the reaction mixture and stirring was continued for 15 min. Subsequently, the reaction mixture was cooled to 0 °C, DMF (1.3 mL, 12 mmol) was added and stirred at this temperature for 2 hours. Upon completion of the reaction, aqueous NH3 (7 mL, 28-30%) and I2 (4.06 g, 16 mmol) were sequentially added to the mixture. After stirring for 2 h at room temperature, the reaction mixture was poured into saturated aqueous Na2SO3 solution and extracted with CHCl3 (3 x 30 mL). The organic layers were combined, dried with Na2SO4 and filtered. After removing the solvent under reduced pressure, the residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 9:1, v/v) to afford pure 3,5-dichlorobenzonitrile (0.73 g) in 71% yield. Most of the nitrile compounds involved in this study were commercially available and were identified by comparison with real samples.

References

[1] Tetrahedron, 2013, vol. 69, # 5, p. 1462 - 1469

3,5-Dichlorobenzonitrile synthesis

Synthesis of 3,5-Dichlorobenzonitrile from 1-Bromo-3,5-dichlorobenzene

3,5-Dichlorobenzonitrile Preparation Products And Raw materials

Raw materials

3,5-Dichlorophenylboronic acid 3,5-DICHLOROBENZAMIDE 1-Bromo-3,5-dichlorobenzene Ammonia ISOPROPYLMAGNESIUM CHLORIDE

iodine Tetrahydrofuran N,N-Dimethylformamide Lithium chloride Water

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Preparation Products

3',5'-Dichloroacetophenone 3-chloro-5-hydroxy-benzonitrile 3,5-DICHLORO-N-HYDROXY-BENZAMIDINE 3,5-DICHLORO-BENZAMIDINE 3,5-DICHLORO-THIOBENZAMIDE

3,5-DICHLOROBENZENE-1-CARBOXIMIDAMIDE HYDROCHLORIDE 3-Chloro-5-[(4-Methoxybenzyl)oxy]benzonitrile

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3,5-Dichlorobenzonitrile Suppliers

Global( 297)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5251	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29733	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21622	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49732	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29801	58
Richest Group Ltd	18017061086	oled@richest-group.com	CHINA	5600	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10035	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co,.LTD	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Jinan Carbotang Biotech Co.,Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Richest Group Ltd	58
Fuxin Pharmaceutical	58

View Lastest Price from 3,5-Dichlorobenzonitrile manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-05-26	3,5-Dichlorobenzonitrile 6575-00-4	US $30.00-10.00 / kg	10kg	99%	100000kg	Hebei Chuanghai Biotechnology Co,.LTD
	2019-12-25	3,5-Dichlorobenzonitrile 6575-00-4	US $1.00 / KG	1KG	99%	200kg	Career Henan Chemical Co

3,5-Dichlorobenzonitrile
6575-00-4
US $30.00-10.00 / kg
99%
Hebei Chuanghai Biotechnology Co,.LTD

3,5-Dichlorobenzonitrile
6575-00-4
US $1.00 / KG
99%
Career Henan Chemical Co

3,5-Dichlorobenzonitrile Spectrum

3,5-Dichlorobenzonitrile(6575-00-4)MS 3,5-Dichlorobenzonitrile(6575-00-4)¹HNMR 3,5-Dichlorobenzonitrile(6575-00-4)¹³CNMR 3,5-Dichlorobenzonitrile(6575-00-4)IR1 3,5-Dichlorobenzonitrile(6575-00-4)IR2 3,5-Dichlorobenzonitrile(6575-00-4)Raman

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3,5-Dichlorobenzenecarbonitrile 3,5-DICHLOROBENZONITRILE 3,5-Dichlorobenzonit 3,5-Dichlorobenzonitrile,97% 3,5-dichlorobenzenenitrile 3,5-Dichlorobenzonitrile 97% Benzonitrile, 3,5-dichloro- 6-chloro-1,3-diethylpyrimidine-2,4-dione 3,5-Dichlorobenzonitrile> 13C6]-3,5-Dichlorobenzonitrile 6575-00-4 C7H3Cl2N Organic Building Blocks Nitrogen Compounds Cyanides/Nitriles C6 to C7 Building Blocks Aromatic Nitriles Phenyls & Phenyl-Het Nitriles Chlorine Compounds Phenyls & Phenyl-Het C6 to C7 Cyanides/Nitriles Nitrogen Compounds Boron, Nitrile, Thio,& TM-Cpds