ChemicalBook >> CAS DataBase List >>4-Nitrophenyl chloroformate
4-Nitrophenyl chloroformate
- CAS No.
- 7693-46-1
- Chemical Name:
- 4-Nitrophenyl chloroformate
- Synonyms
- 4-NITROPHENYL CARBONOCHLORIDATE;P-NITROPHENYL CHLOROFORMATE;PNPCF;Nitrophenyl chloroforMate;PARA-NITROPHENYL CHLOROFORMATE;4-Nitrophenyl chloridocarbonate;4-NITROPHENYL CHLOROCARBONATE;CHLOROFORMIC ACID P-NITROPHENYL ESTER;CARBONOCHLORIDIC ACID, 4-NITROPHENYL ESTER;p-Nitrophenyl c
- CBNumber:
- CB7348509
- Molecular Formula:
- C7H4ClNO4
- Molecular Weight:
- 201.56
- MDL Number:
- MFCD00007321
- MOL File:
- 7693-46-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 05:26:53
| Product description | Number | Pack Size | Price |
| 4-Nitrophenyl chloroformate 96% | 160210 | 5g | $82.8 |
| 4-Nitrophenyl chloroformate 96% | 160210 | 25g | $250 |
| 4-Nitrophenyl Chloroformate >98.0%(T) | C1400 | 25g | $99 |
| 4-Nitrophenyl Chloroformate >98.0%(T) | C1400 | 250g | $614 |
| 4-Nitrophenyl chloroformate Asreported | 284934 | 100g | $326 |
| More product size | |||
| Melting point | 77-79 °C(lit.) |
|---|---|
| Boiling point | 159-162 °C19 mm Hg(lit.) |
| Density | 1.5719 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| Flash point | >110°C |
| storage temp. | 2-8°C |
| solubility | Soluble in acetone, chloroform, acetone, toluene and benzene. |
| form | isopropanol suspension |
| color | White to yellow-beige |
| Water Solubility | decomposes |
| Sensitive | Lachrymatory |
| BRN | 518127 |
| Stability | Stable. Incompatible with strong bases, acids. Combustible. |
| Major Application | peptide synthesis |
| InChI | 1S/C7H4ClNO4/c8-7(10)13-6-3-1-5(2-4-6)9(11)12/h1-4H |
| InChIKey | NXLNNXIXOYSCMB-UHFFFAOYSA-N |
| SMILES | [O-][N+](=O)c1ccc(OC(Cl)=O)cc1 |
| CAS DataBase Reference | 7693-46-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Carbonochloridic acid, 4-nitrophenyl ester(7693-46-1) |
| EPA Substance Registry System | Carbonochloridic acid, 4-nitrophenyl ester (7693-46-1) |
| UNSPSC Code | 12352108 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H335 | |||||||||
| Precautionary statements | P260-P271-P280-P301+P330+P331-P303+P361+P353-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C,T,Xi,F | |||||||||
| Risk Statements | 34-36/37-23/24/25-41-36/37/38-11-67-36 | |||||||||
| Safety Statements | 26-36/37/39-45-38-28A-36-16-27 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 19-21 | |||||||||
| Hazard Note | Toxic/Corrosive/Lachrymator | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29159020 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Eye Dam. 1 Skin Corr. 1B STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
4-Nitrophenyl chloroformate price More Price(62)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 160210 | 4-Nitrophenyl chloroformate 96% | 7693-46-1 | 5g | $82.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | 160210 | 4-Nitrophenyl chloroformate 96% | 7693-46-1 | 25g | $250 | 2026-04-30 | Buy |
| TCI Chemical | C1400 | 4-Nitrophenyl Chloroformate >98.0%(T) | 7693-46-1 | 25g | $99 | 2026-04-30 | Buy |
| TCI Chemical | C1400 | 4-Nitrophenyl Chloroformate >98.0%(T) | 7693-46-1 | 250g | $614 | 2026-04-30 | Buy |
| Usbiological | 284934 | 4-Nitrophenyl chloroformate Asreported | 7693-46-1 | 100g | $326 | 2026-06-03 | Buy |
4-Nitrophenyl chloroformate Chemical Properties,Uses,Production
Chemical Properties
Cream solid
Uses
4-Nitrophenyl chloroformate can be used:
- As a reagent for the activation of amines, alcohols and thiols.
- In the synthesis of 4-substituted phenyl derivatives of 1,2,4-triazolidindiones (urazoles).
- In the solid-phase synthesis of 3-aryl-2,4-quinazolinedione derivatives with potent anti-cancer property.
- In the preparation of poly(oxyethylene) modified dextrans.
- To synthesize a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA.
Uses
4-Nitrophenyl chloroformate is used in the synthesis of poly(oxyethylene) modified dextrans. It is also used to prepare a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA. Further, it is used in the synthesis of mixed, activated carbonates, thiocarbonates and activated urethanes. In addition to this, it is used in the preparation of 4-nitrophenyl diazoacetate with diazomethane. It is an ester of chloroformic acid used in the immobilization of enzymes and other biomolecules.
Application
4-Nitrophenyl chloroformate is used as:A coupling agent to link the drug molecule with the polyrotaxane carrier molecule.As an activated ester reagent that enables the covalent coupling of a peptide onto a macromer, such as oligo(poly(ethylene glycol) fumarate) (OPF).
Description
4-Nitrophenyl chloroformate, also known as p-nitrophenyl chloroformate, is a coupling agent used in the synthesis of ureas, carbamates, and carbonates. It is also used as a building block in solid-phase peptide synthesis (SPPS) to obtain altered side chain functionalities in peptides.
reaction suitability
reaction type: Carbonylations
4-Nitrophenyl chloroformate Preparation Products And Raw materials
Global( 547)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1085 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14014 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21586 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6366 | 58 |
View Lastest Price from 4-Nitrophenyl chloroformate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 4-Nitrophenyl chloroformate
7693-46-1
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-12-01 | 4-Nitrophenyl chloroformate
7693-46-1
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-09-25 | 4-Nitrophenyl chloroformate
7693-46-1
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd |
-
- 4-Nitrophenyl chloroformate
7693-46-1
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-Nitrophenyl chloroformate
7693-46-1
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-Nitrophenyl chloroformate
7693-46-1
- $1.00-100.00
- 99%
- Henan Fengda Chemical Co., Ltd
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7693-46-1
7963-46-1
231-706-9
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ClCO2C6H4NO2
Coupling
Synthetic Reagents
Protection & Derivatization Reagents (for Synthesis)
Active Esters/Additives
Pharmaceutical intermediates
Protection & Derivatization Reagents (for Synthesis)
Synthetic Organic Chemistry
