Pinostrobin
- CAS No.
- 480-37-5
- Chemical Name:
- Pinostrobin
- Synonyms
- Pistrobin;Pinostobin;PINOSTROBIN;Pinostrombin;loteprednol Impurity 18;Pinostrobin, 10 mM in DMSO;5-Hydroxy-7-methoxyflavanone;5-Hydroxy-7-methoxy-2-phenyl-chroman-4-one;PINOCEMBRIN-7-METHYLETHER(RG)(PLEASE CALL);5-Hydroxy-7-methoxyflavanone (Pinostrobin)
- CBNumber:
- CB7350900
- Molecular Formula:
- C16H14O4
- Molecular Weight:
- 270.28
- MDL Number:
- MFCD06858342
- MOL File:
- 480-37-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Pinostrobin ≥98% | 22436 | 5mg | $38 |
| Pinostrobin ≥98% | 22436 | 1mg | $38 |
| Pinostrobin ≥98% | 22436 | 10mg | $72 |
| Pinostrombin | H947653 | 10mg | $1400 |
| Pinostrobin | FP66572 | 50mg | $150 |
| More product size | |||
| Melting point | 100°C |
|---|---|
| Boiling point | 494.9±45.0 °C(Predicted) |
| Density | 1.284±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF: 20 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 12 mg/ml |
| pka | 7.40±0.40(Predicted) |
| form | A crystalline solid |
| color | White to yellow |
| InChI | InChI=1S/C16H14O4/c1-19-11-7-12(17)16-13(18)9-14(20-15(16)8-11)10-5-3-2-4-6-10/h2-8,14,17H,9H2,1H3/t14-/m0/s1 |
| InChIKey | ORJDDOBAOGKRJV-AWEZNQCLSA-N |
| SMILES | [C@H]1(C2=CC=CC=C2)OC2=CC(OC)=CC(O)=C2C(=O)C1 |
| LogP | 3.591 (est) |
| FDA UNII | SZD9LZS694 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
Pinostrobin price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22436 | Pinostrobin ≥98% | 480-37-5 | 5mg | $38 | 2024-03-01 | Buy |
| Cayman Chemical | 22436 | Pinostrobin ≥98% | 480-37-5 | 1mg | $38 | 2023-06-20 | Buy |
| Cayman Chemical | 22436 | Pinostrobin ≥98% | 480-37-5 | 10mg | $72 | 2024-03-01 | Buy |
| TRC | H947653 | Pinostrombin | 480-37-5 | 10mg | $1400 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FP66572 | Pinostrobin | 480-37-5 | 50mg | $150 | 2021-12-16 | Buy |
Pinostrobin Chemical Properties,Uses,Production
Description
Pinostrobin is a flavonoid with diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties. It induces quinone reductase (QR) in murine hepatoma cells with a QR doubling concentration of 500 nM. Pinostrobin inhibits TNF-α and IL-1β production in RAW 264.7 macrophages (IC50s = 17.28 and 23.5 μM, respectively) and in LPS-stimulated rats (48.6 and 55% reduction, respectively). Pinostrobin also shows selective cytotoxicity for CCRF-CEM leukemia cells (IC50 = 10.2 μM) in a panel of eight cancer cell lines (IC50s = >30 μM).
Uses
Pinostrombin is a useful research chemical that can be used for chemical fingerprinting, isolating, and characterizing of polyphenol compounds. It can also be used as a potential compound for TMPRSS2 inhibition for Covid-19 therapy.
Definition
ChEBI: A monohydroxyflavanone that is (2S)-flavanone substituted by a hydroxy group at position 5 and a methoxy group at position 7 respectively.
References
[1] NEERAJ K. PATEL Kamlesh K B Gaurav Jaiswal. A review on biological sources, chemistry and pharmacological activities of pinostrobin[J]. Natural Product Research, 2016, 30 18: Pages 2017-2027. DOI: 10.1080/14786419.2015.1107556
[2] JED W. FAHEY Katherine K S. Pinostrobin from Honey and Thai Ginger (Boesenbergia pandurata): A Potent Flavonoid Inducer of Mammalian Phase 2 Chemoprotective and Antioxidant Enzymes[J]. Journal of Agricultural and Food Chemistry, 2002, 50 25: 7472-7476. DOI: 10.1021/jf025692k
[3] NEERAJ K. PATEL Kamlesh K B. Pinostrobin and Cajanus lactone isolated from Cajanus cajan (L.) leaves inhibits TNF-α and IL-1β production: In vitro and in vivo experimentation[J]. Phytomedicine, 2014, 21 7: Pages 946-953. DOI: 10.1016/j.phymed.2014.02.011
[4] J.S. ASHIDI . Ethnobotanical survey and cytotoxicity testing of plants of South-western Nigeria used to treat cancer, with isolation of cytotoxic constituents from Cajanus cajan Millsp. leaves[J]. Journal of ethnopharmacology, 2010, 128 2: Pages 501-512. DOI: 10.1016/j.jep.2010.01.009
Pinostrobin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3589 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 954 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52746 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | sale03@alfachem.cn | China | 9299 | 58 |
View Lastest Price from Pinostrobin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-12 | Pinostrobin
480-37-5
|
US $1.00-2.10 / KG | 1KG | 99% | 20000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-12-31 | Pinostrobin
480-37-5
|
US $1.00 / KG | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
-
- Pinostrobin
480-37-5
- US $1.00-2.10 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Pinostrobin
480-37-5
- US $1.00 / KG
- 95-99%
- Career Henan Chemical Co
