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Prochlorperazine

Prochlorperazine Structure
Prochlorperazine structure
CAS No.
58-38-8
Chemical Name:
Prochlorperazine
Synonyms
Compazine;Stemetil;PERPHENAZINE BASE;6140rp;rp6140;6140 RP;Emelent;Nipodal;RP-6140;skf4657
CBNumber:
CB7352500
Molecular Formula:
C20H24ClN3S
Molecular Weight:
373.94
MDL Number:
MFCD00056797
MOL File:
58-38-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:30:10
Product description Number Pack Size Price
2-Chloro-10-(3-[1-methyl-4-piperazinyl]propyl)phenothiazine 99% AA003TVX 100mg $147
2-Chloro-10-(3-[1-methyl-4-piperazinyl]propyl)phenothiazine 99% AA003TVX 500mg $365
Prochlorperazine 97% MT-58164 50g $430
Prochlorperazine 97% MT-58164 50g $430
Prochlorperazine >98% DC10260 100mg $100
More product size
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Prochlorperazine Properties

Melting point 228 °C
Boiling point 260-275 °C(Press: 2 Torr)
Density 1.1679 (rough estimate)
refractive index 1.6000 (estimate)
storage temp. Refrigerator
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka pKa 8.1(H2O,t =24±1,I undefined) (Uncertain)
form Solid
color White to Yellow
Water Solubility 14.96mg/L(24 ºC)
BCS Class 2
InChI InChI=1S/C20H24ClN3S/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24/h2-3,5-8,15H,4,9-14H2,1H3
InChIKey WIKYUJGCLQQFNW-UHFFFAOYSA-N
SMILES C1=C2C(SC3=C(N2CCCN2CCN(C)CC2)C=CC=C3)=CC=C1Cl
CAS DataBase Reference 58-38-8(CAS DataBase Reference)
NCI Dictionary of Cancer Terms prochlorperazine
FDA UNII YHP6YLT61T
NCI Drug Dictionary prochlorperazine
ATC code N05AB04
NIST Chemistry Reference Prochlorperazine(58-38-8)
UNSPSC Code 41116107
NACRES NA.24

Pharmacokinetic data

Protein binding 96%
Excreted unchanged in urine Minimal
Volume of distribution 23(L/kg)
Biological half-life 6-9 / -

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)Exclamation Mark (GHS07)
GHS08,GHS07
Signal word  Warning
Hazard statements  H302-H336-H361d-H362
Precautionary statements  P201-P260-P263-P301+P312+P330-P308+P313
target organs Central nervous system
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Lact.
Repr. 2
STOT SE 3
Hazardous Substances Data 58-38-8(Hazardous Substances Data)
Toxicity LD50 oral in rat: 1800mg/kg

Prochlorperazine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
aablocks AA003TVX 2-Chloro-10-(3-[1-methyl-4-piperazinyl]propyl)phenothiazine 99% 58-38-8 100mg $147 2026-05-28 Buy
aablocks AA003TVX 2-Chloro-10-(3-[1-methyl-4-piperazinyl]propyl)phenothiazine 99% 58-38-8 500mg $365 2026-05-28 Buy
AHH MT-58164 Prochlorperazine 97% 50g $430 2026-05-26 Buy
AHH MT-58164 Prochlorperazine 97% 50g $430 2026-05-25 Buy
DC Chemicals DC10260 Prochlorperazine >98% 58-38-8 100mg $100 2026-05-24 Buy
Product number Packaging Price Buy
AA003TVX 100mg $147 Buy
AA003TVX 500mg $365 Buy
MT-58164 50g $430 Buy
MT-58164 50g $430 Buy
DC10260 100mg $100 Buy

Prochlorperazine Chemical Properties,Uses,Production

Uses

antiemetic, antipsychotic, treatment of vertigo

Uses

Prochlorperazine is antiemetic, antipsychotic; used in treatment of vertigo.

Definition

ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.

brand name

Compazine (GlaxoSmithKline).

Clinical Use


Nausea and vomiting
Labyrinthine disorders
Psychoses
Severe anxiety

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human systemic effects by ingestion: headache, blood pressure elevation. Implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl-.

Veterinary Drugs and Treatments

Prochlorperazine as a single agent is used in dogs and cats as an antiemetic. The only approved products for animals are combination products containing prochlorperazine, isopropamide, with or without neomycin (Darbazine, Neo-Darbazine—SKB Labs) which are no longer marketed in the USA. The approved indications for these products include: vomiting, non-specific gastroenteritis, drug induced diarrhea, infectious diarrhea, spastic colitis, and motion sickness in dogs and cats (injectable product only).

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: increased risk of convulsions with tramadol; enhanced hypotensive and sedative effects with opioids; increased risk of ventricular arrhythmias with methadone.
Anti-arrhythmics increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval, e.g. procainamide, disopyramide, dronedarone and amiodarone - avoid with amiodarone and dronedarone.
Antibacterials: increased risk of ventricular arrhythmias with delamanid and moxifloxacin - avoid.
Antidepressants: increase concentrations and additive antimuscarinic effects, notably with tricyclics; increased risk of ventricular arrhythmias with citalopram and escitalopram - avoid; increased risk of convulsions with vortioxetine.
Antiepileptics: antagonised (convulsive threshold lowered).
Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol.
Antipsychotics: increased risk of ventricular arrhythmias with droperidol and pimozide - avoid; increased risk of ventricular arrhythmias with risperidone.
Antivirals: concentration possibly increased with ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid.
Anxiolytics and hypnotics: increased sedative effects.
Atomoxetine: increased risk of ventricular arrhythmias.
Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalol.
Cytotoxics: increased risk of ventricular arrhythmias with arsenic trioxide.
Desferrioxamine: avoid concomitant use.
Diuretics: enhanced hypotensive effect.
Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity.
Pentamidine: increased risk of ventricular arrhythmias.

Metabolism

Prochlorperazine undergoes extensive first pass metabolism in the gut wall. It is also extensively metabolised in the liver and is excreted in the urine and bile. The metabolites are inactive.

Prochlorperazine Preparation Products And Raw materials

Raw materials

Preparation Products

PERPHENAZINE

Prochlorperazine Suppliers

Global( 107)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30224 58
Baoji Guokang Healthchem Co., Ltd. 		+86-0917-3909592 +86-13892490616 gksales1@gk-bio.com China 9063 58
LUYUNJIA CHEMISTRY XIAMEN LIMITED 		+86-592-5360779 +86-13055435203 China 5988 58
Shaanxi Didu New Materials Co. Ltd 		+86-86-17392712779 +8617792793228 1069@dideu.com China 8661 58
GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490 info@gihichemicals.com China 49934 58
SUZHOU SENFEIDA CHEMICAL CO.,LTD 		+86-0512-83500002 +8618662433356 3899766280@qq.com China 26362 58
Xiamen Wonderful Bio Technology Co., Ltd. 		+8613043004613 Sara@xmwonderfulbio.com China 283 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 43333 58
Xiamen Eagle Chemical Limited Corporation 		yiyunchem@163.com China 5687 58
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
Career Henan Chemica Co 		58
Baoji Guokang Healthchem Co., Ltd. 		58
LUYUNJIA CHEMISTRY XIAMEN LIMITED 		58
Shaanxi Didu New Materials Co. Ltd 		58
GIHI CHEMICALS CO.,LIMITED 		58
SUZHOU SENFEIDA CHEMICAL CO.,LTD 		58
Xiamen Wonderful Bio Technology Co., Ltd. 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Xiamen Eagle Chemical Limited Corporation 		58

View Lastest Price from Prochlorperazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Prochlorperazine pictures 2026-06-30 Prochlorperazine
58-38-8
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
Prochlorperazine pictures 2024-10-22 Prochlorperazine
58-38-8
 $1.80 1g 96%-99% 1kg/10kg/100kg Career Henan Chemica Co
prochlorperazine pictures 2024-01-18 prochlorperazine
58-38-8
 $30.00 1kg 99% 6000 Xiamen Wonderful Bio Technology Co., Ltd.

58-38-8(Prochlorperazine)Related Search:

2-Chlorophenothiazine Chlorpromazine hydrochloride Allyl chloride 3-Chloropropyltrimethoxysilane Chloromethyl isopropyl carbonate
Chlorpromazine Phenothiazine 3-Methyl-2-butanone Cyclopropyl methyl ketone Xylazine
1-Methylpiperazine Imiclopazine FLUPHENAZINE Difluorochloromethane PROCHLORPERAZINE MALEATE
Fluphenazine decanoate Methophenazine PROCHLORPERAZINE MESYLATE

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10H-Phenothiazine, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]- 2-Chloro-10-(3-(1-methyl-4-piperazinyl)-propyl)-phenothiazine 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-10h-phenothiazin 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-phenothiazin 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine 2-Chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine 3-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine 3-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine 6140 R.P. 6140 RP 6140rp Bayer A 173 bayera173 Capazine Chlormeprazine Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine chloro-3(n-methylpiperazinyl-3propyl)-10phenothiazine chloro-3(n-methylpiperazinyl-3propyl)-10phenothiazine(french) Chlorperazine Compazine Emelent Eskatrol Kronocin Meterazin Meterazine n-(gamma-(4’-methylpiperazinyl-1’)propyl)-3-chlorophenothiazine N-(gamma-(4'-Methylpiperazinyl-1')propyl)-3-chlorophenothiazine n-[gamma-(4’-methylpiperazinyl-1’)propyl]-3-chlorophenothiazine Nipodal Phenothiazine, 2-chloro-10-[3-(1-methyl-4-piperazinyl)propyl]- Chloromeprazine 3-Chloro-10-chlorperazine 10-[3-(4-Methylpiperazino)propyl]-2-chloro-10H-phenothiazine Prochlorperazine Base PERPHENAZINE BASE Phenothiazine, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]- Prochloroperazine Prochlorpemazine Prochlorperazin prochlorpermazine Prochlorpromazine Procloperazine Proclorperazine rp6140 RP-6140 SKF 4657 skf4657 Tementil Temetid PROCHLORPERAZINE 2-chloro-10-(3-(4-methylpiperazin-1-yl)propyl)phenothiazine Bayer A 17 10H-PHENOTHIAZINE, 2-CHLORO-10-[3-(4-METHYL-1-PIPERAZINYL)PROPYL]-, (Z)-2-BUTENEDIOATE Prochlorperazine USP/EP/BP Prochlorperazine EP Propachloropiperazine monomer Praziquantel Impurity 7-d11 Stemetil