Flavopiridol
- CAS No.
- 146426-40-6
- Chemical Name:
- Flavopiridol
- Synonyms
- Alvocidib;CS-180;C077990;L86-8275;L-868275;L 868275;Hmr 1275;Flavopirodol;FLAVOPIRIDOL;HMR-1275; L86-8275
- CBNumber:
- CB7362013
- Molecular Formula:
- C21H20ClNO5
- Molecular Weight:
- 401.84
- MDL Number:
- MFCD20501884
- MOL File:
- 146426-40-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Flavopiridol ≥95% | 26024 | 5mg | $57 |
| Flavopiridol ≥95% | 26024 | 25mg | $208 |
| Flavopiridol ≥95% | 26024 | 50mg | $384 |
| Flavopiridol ≥95% | 26024 | 100mg | $656 |
| Flavopiridol >99% | orb154639 | 100mg | $690.2 |
| More product size | |||
| Melting point | 52.5 °C |
|---|---|
| Boiling point | 603.6±55.0 °C(Predicted) |
| Density | 1.448±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | insoluble in H2O; ≥40.2 mg/mL in DMSO; ≥85.4 mg/mL in EtOH with gentle warming and ultrasonic |
| pka | 6.16±0.40(Predicted) |
| form | Yellow powder. |
| color | Light yellow to yellow |
| InChIKey | BIIVYFLTOXDAOV-YVEFUNNKSA-N |
| SMILES | C1(C2=CC=CC=C2Cl)OC2=C([C@H]3CCN(C)C[C@H]3O)C(O)=CC(O)=C2C(=O)C=1 |
| CAS DataBase Reference | 146426-40-6(CAS DataBase Reference) |
| FDA UNII | 45AD6X575G |
| NCI Dictionary of Cancer Terms | alvocidib; flavopiridol; HMR 1275 |
| NCI Drug Dictionary | alvocidib |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| HS Code | 2934999090 | |||||||||
| NFPA 704 |
|
Flavopiridol price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26024 | Flavopiridol ≥95% | 146426-40-6 | 5mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 26024 | Flavopiridol ≥95% | 146426-40-6 | 25mg | $208 | 2024-03-01 | Buy |
| Cayman Chemical | 26024 | Flavopiridol ≥95% | 146426-40-6 | 50mg | $384 | 2024-03-01 | Buy |
| Cayman Chemical | 26024 | Flavopiridol ≥95% | 146426-40-6 | 100mg | $656 | 2024-03-01 | Buy |
| Biorbyt Ltd | orb154639 | Flavopiridol >99% | 146426-40-6 | 100mg | $690.2 | 2021-12-16 | Buy |
Flavopiridol Chemical Properties,Uses,Production
Uses
Antineoplastic (cyclin-dependent kinase inhibitor)[Note—The trivial name, flavopiridol, has appeared in literature].
Uses
Flavopiridol is a synthetic flavonoid derivative, potent inhibitor of CDKs. Inhibitor of CDK9 as a postexposure drug target for adenoviruses.
Definition
ChEBI: Alvocidib is a synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. It has a role as an antineoplastic agent, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an antirheumatic drug and an apoptosis inducer. It is a dihydroxyflavone, a hydroxypiperidine, a member of monochlorobenzenes and a tertiary amino compound. It is a conjugate base of an alvocidib(1+).
Anticancer Research
It is a synthetic derivative of rohitukine plant alkaloid which is obtained fromDysoxylum binectariferum, which is active against leukemia, lymphomas and solidtumors (Shoeb 2006).
IC 50
CDK1/Cyc B1: 30 nM (IC50); CDK2/Cyc E: 170 nM (IC50); CDK4/Cyc D1: 100 nM (IC50); MAP: 19000 nM (IC50); PKC: 14000 nM (IC50); EGFR: 22000 nM (IC50)
Flavopiridol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32469 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15081 | 58 |
View Lastest Price from Flavopiridol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-13 | Flavopiridol
146426-40-6
|
US $34.00-74.00 / mg | 99.99% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-07-02 | Flavopiridol
146426-40-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2020-01-10 | Flavopiridol
146426-40-6
|
US $3.00 / KG | 1KG | 98% | 200KG | Career Henan Chemical Co |
-
- Flavopiridol
146426-40-6
- US $34.00-74.00 / mg
- 99.99%
- TargetMol Chemicals Inc.
-
- Flavopiridol
146426-40-6
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Flavopiridol
146426-40-6
- US $3.00 / KG
- 98%
- Career Henan Chemical Co
