Cycloleucine
- CAS No.
- 52-52-8
- Chemical Name:
- Cycloleucine
- Synonyms
- x201;X 201;cb1639;CYCLEU;CB 1639;nsc1026;wr14997;NSC 1026;WR 14997;wr14,997
- CBNumber:
- CB7376009
- Molecular Formula:
- C6H11NO2
- Molecular Weight:
- 129.16
- MDL Number:
- MFCD00001381
- MOL File:
- 52-52-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Cycloleucine 97% | A48105 | 5g | $222 |
| Cycloleucine 97% | A48105 | 10g | $349 |
| 1-Aminocyclopentanecarboxylic Acid >98.0%(T) | A1063 | 1g | $33 |
| 1-Aminocyclopentanecarboxylic Acid >98.0%(T) | A1063 | 5g | $93 |
| 1-Aminocyclopentanecarboxylic Acid >98.0%(T) | A1063 | 25g | $279 |
| More product size | |||
| Melting point | 320 °C (dec.) (lit.) |
|---|---|
| Boiling point | 239.22°C (rough estimate) |
| Density | 1.1426 (rough estimate) |
| refractive index | 1.4827 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO: < 1 mg/mL (ultrasonic) (insoluble or slightly soluble) |
| pka | 2.38±0.20(Predicted) |
| form | Crystalline Flakes or Powder |
| color | White to beige |
| Water Solubility | 5 g/100 mL |
| Merck | 14,2734 |
| BRN | 636626 |
| Major Application | peptide synthesis |
| InChI | 1S/C6H11NO2/c7-6(5(8)9)3-1-2-4-6/h1-4,7H2,(H,8,9) |
| InChIKey | NILQLFBWTXNUOE-UHFFFAOYSA-N |
| SMILES | NC1(CCCC1)C(O)=O |
| CAS DataBase Reference | 52-52-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 0TQU7668EI |
| NCI Drug Dictionary | cycloleucine |
| NIST Chemistry Reference | Cyclopentanecarboxylic acid, 1-amino-(52-52-8) |
| EPA Substance Registry System | Cyclopentanecarboxylic acid, 1-amino- (52-52-8) |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P310+P330 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GY2625000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29224999 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral | |||||||||
| Hazardous Substances Data | 52-52-8(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 oral in rat: 290mg/kg | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Cycloleucine price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A48105 | Cycloleucine 97% | 52-52-8 | 5g | $222 | 2026-04-30 | Buy |
| Sigma-Aldrich | A48105 | Cycloleucine 97% | 52-52-8 | 10g | $349 | 2026-04-30 | Buy |
| TCI Chemical | A1063 | 1-Aminocyclopentanecarboxylic Acid >98.0%(T) | 52-52-8 | 1g | $33 | 2026-04-30 | Buy |
| TCI Chemical | A1063 | 1-Aminocyclopentanecarboxylic Acid >98.0%(T) | 52-52-8 | 5g | $93 | 2026-04-30 | Buy |
| TCI Chemical | A1063 | 1-Aminocyclopentanecarboxylic Acid >98.0%(T) | 52-52-8 | 25g | $279 | 2026-04-30 | Buy |
Cycloleucine Chemical Properties,Uses,Production
Chemical Properties
WHITE TO BEIGE CRYSTALLINE FLAKES OR POWDER
Uses
NMDA receptor antagonist, inhibits nucleic acid methylation; adrenergic agonist
Uses
Cycloleucine can be used as a building block to synthesize:
- Phosphonylmethylaminocyclopentane-1-carboxylic acid by reacting with paraformaldehyde and diethylphosphite via Kabachnik-Field′s reaction.
- Benzo[b]thiophene-2-carboxylic acid {1-[1-(R)-(3-morpholin-4-ylpropylcarbamoyl)-2-phenylethylcarbamoyl]cyclopentyl}-amide, (MEN14268) as potential tachykinin NK2 receptor antagonist.
Uses
Cycloleucine is a synthetic amino acid used in numerous biochemical transport studies
Definition
ChEBI: A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups.
General Description
Cycloleucine is a nonmetabolizable amino acid widely used as a building block in peptide synthesis.
reaction suitability
reaction type: solution phase peptide synthesis
Purification Methods
Any Cl -or other anions are removed by stirring with a strong cation exchange resin (Amberlite IR-120), filtering, and washing with distilled H2O until the filtrate is free from the anion. The resin is then stirred overnight with 6N NH4OH, filtered, the filtrate is decolourised (charcoal) and evaporated to dryness in a vacuum. The residue is recrystallised from H2O/EtOH. Also crystallise it from aqueous EtOH. The hydrochloride has m 222-224o(dec). [Neelakantan & Hartung J Org Chem 23 967 1958, Connors & Ross J Chem Soc 2119 1960. O’Donnell et al. Synthesis 127 1984, Beilstein 14 IV 974.]
Cycloleucine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21590 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
View Lastest Price from Cycloleucine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Cycloleucine
52-52-8
|
US $39.00-68.00 / mg | 99.90% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-09-25 | Cycloleucine
52-52-8
|
US $30.00-0.80 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2021-07-13 | Cycloleucine
52-52-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Cycloleucine
52-52-8
- US $39.00-68.00 / mg
- 99.90%
- TargetMol Chemicals Inc.
-
- Cycloleucine
52-52-8
- US $30.00-0.80 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Cycloleucine
52-52-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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