3-CHLORO-2-FLUORONITROBENZENE
- CAS No.
- 2106-49-2
- Chemical Name:
- 3-CHLORO-2-FLUORONITROBENZENE
- Synonyms
- 5-Chloro-2-fluoroaniline;1-CHLORO-2-FLUORO-3-NITRO-BENZENE;3-chioro-2-fluoronitrobenzene;2-Fluoro-3-nitrochlorobenzene;3-CHLORO-2-FLUORONITROBENZENE;2-FLUORO-3-CHLORO-NITROBENZENE;3-Chloro-2-fluoro-1-nitrobenzene;3-CHLORO-2-FLUORONITROBENZENE,99%;Benzene, 1-chloro-2-fluoro-3-nitro-;1-Chloro-2-fluoro-3-nitrobenzene,97%
- CBNumber:
- CB7384301
- Molecular Formula:
- C6H3ClFNO2
- Molecular Weight:
- 175.54
- MDL Number:
- MFCD00069417
- MOL File:
- 2106-49-2.mol
| Melting point | 36-40 |
|---|---|
| Boiling point | 106 °C(Press: 5 Torr) |
| Density | 1.494±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | Liquid |
| color | Yellow |
| Water Solubility | Soluble in water. |
| CAS DataBase Reference | 2106-49-2(CAS DataBase Reference) |
| FDA UNII | XJ58RN24KX |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H315-H319-H331-H335 | |||||||||
| Precautionary statements | P261-P280-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| RIDADR | 2810 | |||||||||
| Hazard Note | Harmful | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2904990090 | |||||||||
| NFPA 704 |
|
3-CHLORO-2-FLUORONITROBENZENE price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C585060 | 1-Chloro-2-fluoro-3-nitrobenzene | 2106-49-2 | 2.5g | $65 | 2021-12-16 | Buy |
| TRC | C585060 | 1-Chloro-2-fluoro-3-nitrobenzene | 2106-49-2 | 500mg | $45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0021502 | 3-CHLORO-2-FLUORO-1-NITROBENZENE 95.00% | 2106-49-2 | 25G | $1819.13 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0021502 | 3-CHLORO-2-FLUORO-1-NITROBENZENE 95.00% | 2106-49-2 | 1G | $664.13 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0021502 | 3-CHLORO-2-FLUORO-1-NITROBENZENE 95.00% | 2106-49-2 | 5G | $1010.63 | 2021-12-16 | Buy |
3-CHLORO-2-FLUORONITROBENZENE Chemical Properties,Uses,Production
Uses
1-Chloro-2-fluoro-3-nitrobenzene is used as pharmaceutical intermediates, agrochemical intermediates, intermediates of medicine.
Synthesis
3209-22-1
2106-49-2
General procedure for the synthesis of 3-chloro-2-fluoronitrobenzene from 2,3-dichloronitrobenzene: 500 g (2.08 mol) of 2,3-dichloronitrobenzene was added to a four-necked flask fitted with a stirrer, a thermometer, and a condenser tube, and heated to 140 °C. Subsequently, 112 g (1.93 mol) of potassium fluoride (KF) was added to the reaction system, subjected to a decompression dehydration operation and held at 140-150 °C for 3 hours. After dehydration was completed, the temperature of the reaction system was raised to 140 °C, and then 6.6 g (0.06 mol) of tetramethylammonium chloride was slowly added between 150 and 160 °C. After the addition was completed, the reaction temperature was adjusted to 165±5°C and the reaction was continued for 8 hours. At the end of the reaction, the heating was stopped and the reaction mixture was allowed to cool to room temperature and washed with deionized water. The organic phase was separated and layered by distillation to recover 100 g of unreacted 2,3-dichloronitrobenzene, and finally 240 g of the target product 3-chloro-2-fluoronitrobenzene was obtained, which had a purity of 99.6% and a yield of 87.6%.
References
[1] Patent: CN102249881, 2016, B. Location in patent: Paragraph 0015; 0039-0040
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 10, p. 1516 - 1529
[3] Journal of the American Chemical Society, 1959, vol. 81, p. 94,95, 97
[4] Patent: US5476976, 1995, A
[5] Patent: US5545768, 1996, A
3-CHLORO-2-FLUORONITROBENZENE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 286 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29733 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Changzhou Carman Chemical Co., Ltd. | 15061933924 | CHINA | 514 | 58 | |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
View Lastest Price from 3-CHLORO-2-FLUORONITROBENZENE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-11-03 | 3-CHLORO-2-FLUORONITROBENZENE
2106-49-2
|
US $10.00 / kg | 1kg | 99% | 100T | Anhui Zhongda Biotechnology Co., Ltd | |
 |
2021-07-02 | 3-CHLORO-2-FLUORONITROBENZENE
2106-49-2
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2019-07-06 | 3-CHLORO-2-FLUORONITROBENZENE
2106-49-2
|
US $1.00 / KG | 1KG | 99% | Customized | Career Henan Chemical Co |
-
- 3-CHLORO-2-FLUORONITROBENZENE
2106-49-2
- US $10.00 / kg
- 99%
- Anhui Zhongda Biotechnology Co., Ltd
-
- 3-CHLORO-2-FLUORONITROBENZENE
2106-49-2
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 3-CHLORO-2-FLUORONITROBENZENE
2106-49-2
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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