Poseltinib
- CAS No.
- 1353552-97-2
- Chemical Name:
- Poseltinib
- Synonyms
- LY-3337641);Poseltinib (HM-71224;Poseltinib (HM71224, LY3337641);2-Propenamide, N-[3-[[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]furo[3,2-d]pyrimidin-4-yl]oxy]phenyl]-
- CBNumber:
- CB74204131
- Molecular Formula:
- C26H26N6O3
- Molecular Weight:
- 470.52
- MDL Number:
- MFCD31729279
- MOL File:
- 1353552-97-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.316±0.06 g/cm3(Predicted) |
|---|---|
| solubility | DMSO:100.0(Max Conc. mg/mL);212.53(Max Conc. mM) |
| pka | 12.85±0.70(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
| FDA UNII | D01E4B1U35 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
Poseltinib price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 37324 | Poseltinib ≥98% | 1353552-97-2 | 1mg | $28 | 2026-04-30 | Buy |
| Cayman Chemical | 37324 | Poseltinib ≥98% | 1353552-97-2 | 5mg | $55 | 2026-04-30 | Buy |
| Cayman Chemical | 37324 | Poseltinib ≥98% | 1353552-97-2 | 10mg | $97 | 2026-04-30 | Buy |
| Cayman Chemical | 37324 | Poseltinib ≥98% | 1353552-97-2 | 25mg | $207 | 2026-04-30 | Buy |
| Biosynth | DEC55297 | Poseltinib | 1353552-97-2 | 5mg | $337.35 | 2026-06-04 | Buy |
Poseltinib Chemical Properties, Uses, Production
Uses
Poseltinib (HM71224) is an orally active, selective, irreversible small molecule Bruton tyrosine kinase (BTK) inhibitor. With an IC50 of 1.95 nM. Poseltinib effectively inhibits the signaling mediated by B cell receptors (BCR), Fc receptors (FcR), and Toll-like receptors (TLR). Poseltinib has anti-inflammatory activity and can be used in the research of rheumatoid arthritis[1][2][3].
in vivo
Poseltinib (3,-30 mg/kg, p.o, once a day, from 18 to 40 weeks) reduces the overactivity of B cells by inhibiting BTK, alleviating the development of systemic lupus erythematosus (SLE) and lupus nephritis (LN)[1].
Poseltinib (1-30 mg/kg p.o, once a day for 2 weeks) improves experimental arthritis in mice [2].
| Animal Model: | MRL/lpr mice and NZB/W F1 mice models[1] |
| Dosage: | 3-30 mg/kg |
| Administration: | p.o |
| Result: | Decreased the spleen weights and prevented skin lesion progression. Ameliorated renal injury and inflammation and improved the survival rate. |
| Animal Model: | Collagen-induced arthritis (CIA) mouse model[2] |
| Dosage: | 1-30 mg/kg |
| Administration: | p.o |
| Result: | Reduced the serum IL-6, circulating anti-collagen antibodies and total IgG levels. Reduced erosive bone changes and prevented bone loss. |
IC 50
TLRs
References
[1] Kim YY, et al. HM71224, a selective Bruton's tyrosine kinase inhibitor, attenuates the development of murine lupus. Arthritis Res Ther. 2017 Sep 26;19(1):211. DOI:10.1186/s13075-017-1402-1
[2] Park JK, et al. HM71224, a novel Bruton's tyrosine kinase inhibitor, suppresses B cell and monocyte activation and ameliorates arthritis in a mouse model: a potential drug for rheumatoid arthritis. Arthritis Res Ther. 2016 Apr 18;18:91. DOI:10.1186/s13075-016-0988-z
[3] Byun JY, et al. Target modulation and pharmacokinetics/pharmacodynamics translation of the BTK inhibitor poseltinib for model-informed phase II dose selection. Sci Rep. 2021 Sep 21;11(1):18671. DOI:10.1038/s41598-021-98255-7
Poseltinib Preparation Products And Raw materials
Raw materials
Preparation Products
Poseltinib Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Struchem Co., Ltd. | 0512-63009836 18994340901 | helen@struchem.com | China | 3966 | 60 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2996 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 18916372613 | yanzihan@shyuanye.com | China | 87240 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9770 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-13601744364 13601744364 | chemsharker@126.com | China | 1203 | 58 |
View Latest Price from Poseltinib manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Poseltinib
1353552-97-2
|
$30.00-44.00 | 99.98% | 10g | TargetMol Chemicals Inc. |
-
- Poseltinib
1353552-97-2
- $30.00-44.00
- 99.98%
- TargetMol Chemicals Inc.
