3-Bromo-5-hydroxypyridine
- CAS No.
- 74115-13-2
- Chemical Name:
- 3-Bromo-5-hydroxypyridine
- Synonyms
- 5-BROMO-3-PYRIDINOL;5-Bromopyridine-3-ol;3-Bromo-5-pyridinol;5-BROMO-PYRIDIN-3-OL;3-Pyridinol, 5-bromo-;3-Hydro-5-broMo-pyridin;3-BROMO-5-HYDROXYPYRIDINE;5-BROMO-3-HYDROXYPYRIDINE;3-Hydroxy-5-bromopyridine;3-Bromo-5-hydroxypyridine95%
- CBNumber:
- CB7423057
- Molecular Formula:
- C5H4BrNO
- Molecular Weight:
- 174
- MDL Number:
- MFCD00661305
- MOL File:
- 74115-13-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Bromo-5-hydroxypyridine 97% | 691836 | 1g | $71.1 |
| 3-Bromo-5-hydroxypyridine >98.0%(GC)(T) | B3969 | 1g | $28 |
| 3-Bromo-5-hydroxypyridine >98.0%(GC)(T) | B3969 | 5g | $92 |
| 5-Bromopyridin-3-ol | 033254 | 1g | $10 |
| 5-Bromopyridin-3-ol | 033254 | 5g | $19 |
| More product size | |||
| Melting point | 166-170 °C |
|---|---|
| Boiling point | 343.7±22.0 °C(Predicted) |
| Density | 1.788±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 8.37±0.10(Predicted) |
| form | Crystalline Powder |
| color | White to tan |
| Water Solubility | Slightly soluble in water. Soluble in chloroform and ethyl acetate. |
| InChI | InChI=1S/C5H4BrNO/c6-4-1-5(8)3-7-2-4/h1-3,8H |
| InChIKey | VNYBIBSZZDAEOK-UHFFFAOYSA-N |
| SMILES | C1=NC=C(Br)C=C1O |
| CAS DataBase Reference | 74115-13-2(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22-20/21/22 | |||||||||
| Safety Statements | 26-36/37/39-37-36-22 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Bromo-5-hydroxypyridine price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 691836 | 3-Bromo-5-hydroxypyridine 97% | 74115-13-2 | 1g | $71.1 | 2023-06-20 | Buy |
| TCI Chemical | B3969 | 3-Bromo-5-hydroxypyridine >98.0%(GC)(T) | 74115-13-2 | 1g | $28 | 2026-04-30 | Buy |
| TCI Chemical | B3969 | 3-Bromo-5-hydroxypyridine >98.0%(GC)(T) | 74115-13-2 | 5g | $92 | 2026-04-30 | Buy |
| Oakwood | 033254 | 5-Bromopyridin-3-ol | 74115-13-2 | 1g | $10 | 2021-12-16 | Buy |
| Oakwood | 033254 | 5-Bromopyridin-3-ol | 74115-13-2 | 5g | $19 | 2021-12-16 | Buy |
3-Bromo-5-hydroxypyridine Chemical Properties,Uses,Production
Description
3-bromo-5-hydroxypyridine is an important industrial raw material widely used in medicine, pesticides, dyes, and other industries. Since the pyridine ring has biological activity and plays an irreplaceable role in synthesising drugs that cannot be replaced by other groups or functional groups, it is a hot area in pharmaceutical research. The hydroxyl and bromine atoms in the structure of 3-bromo-5-hydroxypyridine have diverse chemical reactivity. The alcohol hydroxyl unit in its structure can undergo nucleophilic substitution reactions with common alkyl halides under alkaline conditions to obtain corresponding ether derivatives.
Chemical Properties
Light yellow needles
Uses
5-Bromo-3-methoxypyridine was refluxed with 20 mL (57%) of hydrogen bromide for 24 hours. The reaction was quenched with saturated sodium bicarbonate solution and the base mixture was extracted with 3 × 50 mL of dichloromethane. The organic fractions were pooled, dried (magnesium sulfate), filtered, and evaporated to give a white solid (3 g, >95% purity) identified as 3-bromo-5-hydroxypyridine by thin layer chromatography.
Synthesis
50720-12-2
74115-13-2
General procedure for the synthesis of 3-bromo-5-hydroxypyridine from 3-bromo-5-methoxypyridine: A mixed solution of 3-bromo-5-methoxypyridine (3318.8 g, 0.1 mol), hydrobromic acid (80 mL, 48%), and glacial acetic acid (60 mL) was stirred and reacted at 120 °C overnight. Subsequently, hydrobromic acid (60 mL, 48%) was slowly added to replenish the solvent lost due to evaporation and the reaction continued to be stirred at 120 °C overnight. Upon completion of the reaction, the reaction mixture was cooled to room temperature and poured into ice water. The pH was adjusted to about 6 with 6N NaOH solution and then extracted with ethyl acetate (2 x 200 mL). The organic layers were combined and dried over anhydrous sodium sulfate and subsequently concentrated under vacuum. The crude product was stirred in dichloromethane (150 mL) and the precipitate was collected by filtration. Finally, the precipitate was washed with dichloromethane to afford 3-bromo-5-hydroxypyridine (34; 15.2 g, 87.4% yield) as a white solid.
References
[1] Patent: US2005/234236, 2005, A1. Location in patent: Page/Page column 13-14
[2] Patent: US2004/198736, 2004, A1. Location in patent: Page/Page column 86
[3] Tetrahedron Letters, 2004, vol. 45, # 18, p. 3607 - 3610
[4] Tetrahedron, 2009, vol. 65, # 4, p. 757 - 764
[5] Patent: WO2006/86068, 2006, A1. Location in patent: Page/Page column 18; 1/6
3-Bromo-5-hydroxypyridine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Hebei Maison Chemical Co.,Ltd. | +8615511852758 | sales@maisonchem.com.cn | China | 484 | 58 |
| Suzhou Nordica Biopharma CO.,LTD | +86-18136148818 +86-18567353071 | 3537297702@qq.com | China | 299 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8736 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
View Lastest Price from 3-Bromo-5-hydroxypyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-30 | 3-Bromo-5-hydroxypyridine
74115-13-2
|
US $31.00-230.00 / g | 25g | 0.99 | 25kg | Shanghai UCHEM Inc. | |
 |
2026-04-30 | 3-Bromo-5-hydroxypyridine
74115-13-2
|
US $5.00 / kg | 1kg | ≥99% | 50mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2025-11-18 | 3-Bromo-5-hydroxypyridine
74115-13-2
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
-
- 3-Bromo-5-hydroxypyridine
74115-13-2
- US $31.00-230.00 / g
- 0.99
- Shanghai UCHEM Inc.
-
- 3-Bromo-5-hydroxypyridine
74115-13-2
- US $5.00 / kg
- ≥99%
- Jinan Finer Chemical Co., Ltd
-
- 3-Bromo-5-hydroxypyridine
74115-13-2
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
74115-13-2(3-Bromo-5-hydroxypyridine)Related Search:
1of4
