2-Chloro-5-fluoroaniline
- CAS No.
- 452-83-5
- Chemical Name:
- 2-Chloro-5-fluoroaniline
- Synonyms
- 2-CHLORO-5-FLUOROANILINE;5-FLUORO-2-CHLOROANILINE;Chlorofluoroaniline 25---;2-Chloro-5-fluoroaniline97%;2-Chloro-5-fluoroaniline >2-Chloro-5-fluorobenzenamine;2-Chloro-5-fluoroaniline 97%;2-Chloro-5-fluorobenzeneamine;2-CHLORO-5-FLUORO-PHENYLAMINE;Benzenamine, 2-chloro-5-fluoro-
- CBNumber:
- CB7437104
- Molecular Formula:
- C6H5ClFN
- Molecular Weight:
- 145.56
- MDL Number:
- MFCD00084852
- MOL File:
- 452-83-5.mol
| Melting point | 26°C |
|---|---|
| Boiling point | 211°C |
| Density | 1.349±0.06 g/cm3(Predicted) |
| refractive index | 1.5560 |
| Flash point | 211°C |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | clear liquid |
| pka | 1?+-.0.10(Predicted) |
| color | Colorless to Light yellow to Light orange |
| Water Solubility | Insoluble in water. |
| FreezingPoint | 17.0 to 22.0 ℃ |
| InChI | InChI=1S/C6H5ClFN/c7-5-2-1-4(8)3-6(5)9/h1-3H,9H2 |
| InChIKey | VWUFOZAFKYOZJB-UHFFFAOYSA-N |
| SMILES | C1(N)=CC(F)=CC=C1Cl |
| CAS DataBase Reference | 452-83-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H227-H302+H312+H332-H315-H319-H302-H311-H332-H373 | |||||||||
| Precautionary statements | P260-P304+P340-P305+P351+P338-P405-P501a-P210-P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P403+P235-P501 | |||||||||
| Hazard Codes | T,Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38-23/24/25-22-36/38-33 | |||||||||
| Safety Statements | 26-36/37/39-45-36/37-28 | |||||||||
| RIDADR | UN2811 | |||||||||
| Hazard Note | Toxic | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214200 | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2-Chloro-5-fluoroaniline price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C1693 | 2-Chloro-5-fluoroaniline >98.0%(GC) | 452-83-5 | 5g | $34 | 2024-03-01 | Buy |
| TRC | C349025 | 2-Chloro-5-fluoroaniline | 452-83-5 | 5g | $75 | 2021-12-16 | Buy |
| Matrix Scientific | 002689 | 2-Chloro-5-fluoroaniline 97% | 452-83-5 | 100g | $90 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC64317 | 2-Chloro-5-fluoroaniline | 452-83-5 | 50g | $110 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC64317 | 2-Chloro-5-fluoroaniline | 452-83-5 | 250g | $450 | 2021-12-16 | Buy |
2-Chloro-5-fluoroaniline Chemical Properties,Uses,Production
Chemical Properties
Yellowish oily liquid or crystal
Uses
2-Chloro-5-fluoroaniline is used as a pharmaceutical intermediate.
Synthesis
345-17-5
452-83-5
The general procedure for the synthesis of 2-chloro-5-fluoroaniline from 2-chloro-5-fluoronitrobenzene was as follows: a mixture of 0.17 g (1 mmol) of 2-chloro-5-fluoronitrobenzene, 1.13 g (5 mmol) of tin(II) chloride dihydrate, and 10 mL of ethanol was stirred for 0.5 hours at 70 °C. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured into 30 mL of water, alkalized with 10% sodium carbonate solution and extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate and evaporated to dryness to give 0.12 g (84.5% yield) of the target product 2-chloro-5-fluoroaniline. The structure of the product was confirmed by 1H-NMR (CDCl3, δ): 4.16 (single peak, 2H, NH2), 6.51-6.77 (multiple peaks, 2H, CH on the benzene ring), 7.09-7.21 (multiple peaks, 1H, CH on the benzene ring).
References
[1] Patent: EP1200406, 2004, B1. Location in patent: Page 14
[2] Green Chemistry, 2012, vol. 14, # 11, p. 3164 - 3174,11
2-Chloro-5-fluoroaniline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 1382 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2176 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
View Lastest Price from 2-Chloro-5-fluoroaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-27 | 2-Chloro-5-fluoroaniline
452-83-5
|
US $1.00 / KG | 1KG | 99% | 200kg | Career Henan Chemical Co |
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- 2-Chloro-5-fluoroaniline
452-83-5
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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