1-Bromo-3-methoxy-5-methylbenzene
- CAS No.
- 29578-83-4
- Chemical Name:
- 1-Bromo-3-methoxy-5-methylbenzene
- Synonyms
- 3-Bromo-5-methylanisole;3-BROMO-5-METHOXYTOLUENE;5-Bromo-3-methoxytoluene;3-Bromo-5-methoxytoluene >3-Methyl-5-methoxyphenyl bromide;1-Bromo-3-methoxy-5-methylbenzene;1-Bromo-5-methoxy-3-methylbenzene;Benzene, 1-bromo-3-methoxy-5-methyl-;1-BROMO-3-METHOXY-5-METHYLBENZENE ISO 9001：2015 REACH;1-Bromo-3-methoxy-5-methylbenzene 3-bromo-5-methoxytoluene
- CBNumber:
- CB7446175
- Molecular Formula:
- C8H9BrO
- Molecular Weight:
- 201.06
- MDL Number:
- MFCD08061916
- MOL File:
- 29578-83-4.mol
- MSDS File:
- SDS
| Melting point | 52℃ |
|---|---|
| Boiling point | 228℃ |
| Density | 1.378 |
| refractive index | 1.5560-1.5600 |
| Flash point | 103℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Chloroform |
| form | clear liquid |
| color | Colorless to Light yellow to Red |
| InChI | InChI=1S/C8H9BrO/c1-6-3-7(9)5-8(4-6)10-2/h3-5H,1-2H3 |
| InChIKey | AOEVRCZZWJWKPG-UHFFFAOYSA-N |
| SMILES | C1(Br)=CC(C)=CC(OC)=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| HS Code | 2909309090 | |||||||||
| NFPA 704 |
|
1-Bromo-3-methoxy-5-methylbenzene price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B3526 | 3-Bromo-5-methoxytoluene >98.0%(GC) | 29578-83-4 | 1g | $23 | 2026-04-30 | Buy |
| TCI Chemical | B3526 | 3-Bromo-5-methoxytoluene >98.0%(GC) | 29578-83-4 | 5g | $52 | 2026-04-30 | Buy |
| TRC | TRC-B685150-500MG | 3-Bromo-5-methylanisole | 29578-83-4 | 500mg | $123 | 2026-06-03 | Buy |
| TRC | TRC-B685150-2G | 3-Bromo-5-methylanisole | 29578-83-4 | 2g | $186 | 2026-06-03 | Buy |
| TRC | TRC-B685150-1G | 3-Bromo-5-methylanisole | 29578-83-4 | 1g | $154 | 2026-06-03 | Buy |
1-Bromo-3-methoxy-5-methylbenzene Chemical Properties,Uses,Production
Chemical Properties
Colorless Oil
Biological Activity
1-BROMO-3-METHOXY-5-METHYLBENZENE is an inhibitor of the phenolic acid transporter (PAT). In vitro studies have shown that 1-BROMO-3-METHOXY-5-METHYLBENZENE inhibits the transport of phenolic acids across the cell membrane, which prevents their uptake and accumulation in cells. It has been shown to inhibit the growth of Aspergillus niger and other fungi. It also has cytotoxic effects on human cells in culture, which may be due to its ability to inhibit fatty acid biosynthesis and disrupt intramolecular interactions with the dibenzofuran ring.
Synthesis
348169-39-1
29578-83-4
The general procedure for the synthesis of 1-bromo-3-methoxy-5-toluene from 4-bromo-2-methoxy-6-methylaniline was as follows: in a 250 mL round-bottomed flask, 4-bromo-2-methoxy-6-methylaniline (5.8 g, 26.84 mmol) was dissolved in acetic acid (49 mL), followed by the addition of concentrated hydrochloric acid (5.6 mL). A 7 mL aqueous solution of sodium nitrite (2.19 g, 31.78 mmol) was slowly added dropwise to the reaction mixture at 0 °C. After the dropwise addition, the reaction mixture was continued to be stirred at 0 °C for 30 min. Subsequently, 50% aqueous hypophosphite solution (56.5 mL) was added at 0 °C. The reaction mixture was stirred at 0 °C for a period of time and then gradually warmed up to room temperature and stirred overnight. After completion of the reaction, ethyl acetate was added for extraction and the organic phase was washed with saturated sodium bicarbonate solution. The organic layer was concentrated and purified by silica gel column chromatography (eluent: 100% hexane) to give a pale liquid product (5.12 g, 95% yield). The 1H NMR (300 MHz, CDCl3) data of the product were as follows: δ 6.97 (s, 1H), 6.87 (s, 1H), 6.64 (s, 1H), 3.80 (s, 3H), 2.36 (s, 3H).
References
[1] Patent: WO2009/5674, 2009, A2. Location in patent: Page/Page column 423
[2] Patent: US2010/204234, 2010, A1. Location in patent: Page/Page column 13-14
[3] Chemistry - A European Journal, 2005, vol. 11, # 3, p. 951 - 959
[4] Journal of Medicinal Chemistry, 2001, vol. 44, # 12, p. 1866 - 1882
1-Bromo-3-methoxy-5-methylbenzene Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Lastest Price from 1-Bromo-3-methoxy-5-methylbenzene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 1-BROMO-3-METHOXY-5-METHYLBENZENE
29578-83-4
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2019-07-06 | 1-BROMO-3-METHOXY-5-METHYLBENZENE
29578-83-4
|
$2.00 | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- 1-BROMO-3-METHOXY-5-METHYLBENZENE
29578-83-4
- $1.00-100.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 1-BROMO-3-METHOXY-5-METHYLBENZENE
29578-83-4
- $2.00
- 99%
- Career Henan Chemical Co
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