5-Hydroxynicotinic acid
- CAS No.
- 27828-71-3
- Chemical Name:
- 5-Hydroxynicotinic acid
- Synonyms
- AKOS NCG-0022;5-Hydroxynicotinic;Nicotinic acid-004;TIMTEC-BB SBB010273;5-Hydroxynicotinic a;5-hydroxy-nicotinicaci;5-Hydroxy nicotic acid;5-HYDROXYNICOTINIC ACID;Hydroxynicotinicacid 5-;5-HydroxynicotinicAcid>
- CBNumber:
- CB7447677
- Molecular Formula:
- C6H5NO3
- Molecular Weight:
- 139.11
- MDL Number:
- MFCD00129117
- MOL File:
- 27828-71-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Hydroxynicotinic acid 97% | 672742 | 1g | $114 |
| 5-Hydroxynicotinic acid 97% | 672742 | 5g | $452 |
| 5-Hydroxynicotinic Acid >98.0%(HPLC)(T) | H1226 | 5g | $87 |
| 5-Hydroxynicotinic acid Asreported | 278635 | 5g | $319 |
| 5-Hydroxynicotinic acid Asreported | 278635 | 10g | $432 |
| More product size | |||
| Melting point | 299 °C |
|---|---|
| Boiling point | 519.3±35.0 °C(Predicted) |
| Density | 1.485±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 2.08±0.10(Predicted) |
| form | powder to crystal |
| color | White to Yellow |
| BRN | 115847 |
| InChI | InChI=1S/C6H5NO3/c8-5-1-4(6(9)10)2-7-3-5/h1-3,8H,(H,9,10) |
| InChIKey | ATTDCVLRGFEHEO-UHFFFAOYSA-N |
| SMILES | C1=NC=C(O)C=C1C(O)=O |
| CAS DataBase Reference | 27828-71-3(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280a-P304+P340-P405-P501a-P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | QT1757500 | |||||||||
| Hazard Note | Harmful/Irritant/Keep Cold | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
5-Hydroxynicotinic acid price More Price(75)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 672742 | 5-Hydroxynicotinic acid 97% | 27828-71-3 | 1g | $114 | 2021-12-16 | Buy |
| Sigma-Aldrich | 672742 | 5-Hydroxynicotinic acid 97% | 27828-71-3 | 5g | $452 | 2021-12-16 | Buy |
| TCI Chemical | H1226 | 5-Hydroxynicotinic Acid >98.0%(HPLC)(T) | 27828-71-3 | 5g | $87 | 2026-04-30 | Buy |
| Usbiological | 278635 | 5-Hydroxynicotinic acid Asreported | 27828-71-3 | 5g | $319 | 2026-06-03 | Buy |
| Usbiological | 278635 | 5-Hydroxynicotinic acid Asreported | 27828-71-3 | 10g | $432 | 2026-06-03 | Buy |
5-Hydroxynicotinic acid Chemical Properties,Uses,Production
Chemical Properties
White to off-white to yellow solid
Uses
5-Hydroxynicotinic acid is a nicotinic acid analog with potential inhibitory effect on the metabolism nicotinic acid by human platelets. Used in the investigation of the hydroxylation mechanism of the flaovoprotein 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase (MHPCO).
Definition
ChEBI: 5-Hydroxynicotinic acid is an aromatic carboxylic acid and a member of pyridines.
Biological Activity
5-Hydroxynicotinic acid is a nicotinic acid analog with potential inhibitory effect on the metabolism nicotinic acid by human platelets. Used in the investigation of the hydroxylation mechanism of the flaovoprotein 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase (MHPCO).
Synthesis
20826-04-4
27828-71-3
Stage A: Synthesis of 5-hydroxynicotinic acid 1. 10.1 g (0.05 mol) of 5-bromonicotinic acid, 10 g of NaOH (dissolved in 63 mL of water), 3.1 g of calcium sulfate pentahydrate, and 0.42 g of copper powder (0-valent) were added to a reaction flask. 2. The reaction mixture was stirred vigorously and heated under reflux conditions for 30 hours. 3. Upon completion of the reaction, the mixture was cooled to room temperature, 4.8 g Na2S-H2O was added and stirring was continued overnight. 4. The reaction mixture was heated to 70 °C and treated by passing H2S gas until the white precipitate completely disappeared (about 3 hours). 5. After cooling to room temperature, the reaction mixture was filtered. 6. Adjust the pH of the filtrate to 5.2 with concentrated hydrochloric acid and filter to collect the precipitate. 7. Adjust the pH of the filtrate again to 4.6 with concentrated hydrochloric acid and filter to collect the white precipitate. 8. 8. The precipitate was washed with water and dried under reduced pressure to give 4.3 g (yield: 62%) of 5-hydroxynicotinic acid (molecular formula: C7H5NO3). Product Characterization: - Appearance: white powder - Melting point: >260°C - 1H NMR (300 MHz, DMSO-d6) δ (ppm): 8.48 (d, J=1.5Hz, 1H), 8.26 (d, J=2.6Hz, 1H), 7.51 (d, J=1.9Hz, 1H) - IR (KBr, cm-1): 3273, 1538, 1393, 1294
Research
5-hydroxynicotinic acid (5HNA) could be used as a model the following questions were addressed: (i) is it possible to promote the crystallization of a tautomeric form dominant in a specific solvent through solvate formation (ii) Does that form persist if the memory of solvation is erased through thermal desolvation
A thermodynamic analysis based on DSC and Calvet drop microcalorimetry results allowed us to rationalize these observations, indicating that (i) 5HNA·H2O is predicted to spontaneously lose water, even for a relative humidity of 100%, hence its robustness is most certainly of kinetical origin; (ii) 5HNA·DMSO is thermodynamically stable when a saturation DMSO pressure can be established over the sample, but becomes unstable when exposed to an atmosphere where the solvent is absent. The kinetically easier desolvation of 5HNA·DMSO compared to 5HNA·H2O may be related to the fact that water is isolated in the crystal lattice (isolated site hydrate) while DMSO is placed in channels (channel solvate)[1].
References
[1] Joseph, Abhinav et al. “Tautomer selection through solvate formation: the case of 5-hydroxynicotinic acid.” CrystEngComm 13 (2019): 2220–2233.
5-Hydroxynicotinic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shijiazhuang Dowell Chemical Co.,Ltd | +86-17692413312 | sell@dowechem.com | China | 89 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 | Sibel@chuanghaibio.com | China | 8737 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 | sales1@chuanghaibio.com | China | 5216 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7239 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 877 | 50 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32997 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21189 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5898 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
View Lastest Price from 5-Hydroxynicotinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-08-14 | 5-Hydroxynicotinic acid
27828-71-3
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
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2026-05-28 | 5-Hydroxy-Nicotinic Acid
27828-71-3
|
$9.00 | 1KG | 99% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-03-20 | 5-Hydroxynicotinic acid
27828-71-3
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 5-Hydroxynicotinic acid
27828-71-3
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 5-Hydroxy-Nicotinic Acid
27828-71-3
- $9.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 5-Hydroxynicotinic acid
27828-71-3
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
