3-Amino-2-bromo-5-fluoropyridine
- CAS No.
- 884495-03-8
- Chemical Name:
- 3-Amino-2-bromo-5-fluoropyridine
- Synonyms
- 2-bromo-5-fluoropyridin-3-amine;3-Amino-2-bromo-5-fL;2-Bromo-5-fluoro-3-pyridinamine;2-broMo-5-fluoro-3-aMinopyridine;3-AMINO-2-BROMO-5-FLUOROPYRIDINE;3-Pyridinamine, 2-bromo-5-fluoro-;2-Bromo-5-fluoro-pyridin-3-ylamine;3-Amino-2-bromo-5-fluoropyridine,97%;3-Amino-2-bromo-5-fluoropyridine 98%;3-Amino-2-bromo-5-fluoropyridine ISO 9001：2015 REACH
- CBNumber:
- CB7449358
- Molecular Formula:
- C5H4BrFN2
- Molecular Weight:
- 191
- MDL Number:
- MFCD05662413
- MOL File:
- 884495-03-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Amino-2-bromo-5-fluoropyridine 97% | 775800 | 1g | $388 |
| 3-Amino-2-bromo-5-fluoropyridine | A595173 | 100mg | $75 |
| 2-bromo-5-fluoropyridin-3-amine | FB105193 | 1g | $75 |
| 3-Amino-2-bromo-5-fluoropyridine 98% | PC48312 | 10g | $208 |
| 2-bromo-5-fluoropyridin-3-amine | FB105193 | 10g | $300 |
| Melting point | 114-116 °C |
|---|---|
| Boiling point | 273.6±35.0 °C(Predicted) |
| Density | 1.813±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | solid |
| pka | -0.50±0.10(Predicted) |
| color | White to off-white |
| InChI | InChI=1S/C5H4BrFN2/c6-5-4(8)1-3(7)2-9-5/h1-2H,8H2 |
| InChIKey | QUZAKZBKMMUARE-UHFFFAOYSA-N |
| SMILES | C1(Br)=NC=C(F)C=C1N |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P305+P351+P338+P310 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
3-Amino-2-bromo-5-fluoropyridine price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 775800 | 3-Amino-2-bromo-5-fluoropyridine 97% | 884495-03-8 | 1g | $388 | 2023-06-20 | Buy |
| TRC | A595173 | 3-Amino-2-bromo-5-fluoropyridine | 884495-03-8 | 100mg | $75 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB105193 | 2-bromo-5-fluoropyridin-3-amine | 884495-03-8 | 1g | $75 | 2021-12-16 | Buy |
| Apolloscientific | PC48312 | 3-Amino-2-bromo-5-fluoropyridine 98% | 884495-03-8 | 10g | $208 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB105193 | 2-bromo-5-fluoropyridin-3-amine | 884495-03-8 | 10g | $300 | 2021-12-16 | Buy |
3-Amino-2-bromo-5-fluoropyridine Chemical Properties,Uses,Production
Description
3-Amino-2-bromo-5-fluoropyridine is a polyhalogenated pyridine with the chemical formula C5H4BrFN2. The compound has three functional groups: amino, bromine and fluorine, which change its reactivity. It is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.
Synthesis
652160-72-0
884495-03-8
Step 1: A suspension of 2-bromo-5-fluoro-3-nitropyridine (4.42 g, 20 mmol) with stannous chloride (SnCl2, 22.56 g, 100 mmol) in ethanol (EtOH, 40 mL) and concentrated hydrochloric acid (HCl, 40 mL) was heated to 60°C and reacted for 1 hour. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. To the residue was added ethyl acetate (EtOAc, 100 mL) and saturated aqueous sodium bicarbonate (NaHCO3). The mixture was filtered through diatomaceous earth (Celite) and extracted with ethyl acetate (100 mL x 3). The organic layers were combined, washed sequentially with saturated sodium bicarbonate solution, water and brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give 3.1 g of 2-bromo-5-fluoropyridin-3-amine as a brown solid (80% yield). Mass spectrum (ESI): m/z = 191.1 [M + 1]+.
References
[1] Patent: WO2013/92940, 2013, A1. Location in patent: Page/Page column 50; 51
3-Amino-2-bromo-5-fluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
3-Amino-2-bromo-5-fluoropyridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29799 | 58 |
| Jinan Liheng Biotechnology Co., Ltd. | 15865262812 | info@lihengpharm.com | CHINA | 938 | 58 |
View Lastest Price from 3-Amino-2-bromo-5-fluoropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-06-25 | 3-Amino-2-bromo-5-fluoropyridine
884495-03-8
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-01-09 | 3-Amino-2-bromo-5-fluoropyridine
884495-03-8
|
US $6.68 / KG | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- 3-Amino-2-bromo-5-fluoropyridine
884495-03-8
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 3-Amino-2-bromo-5-fluoropyridine
884495-03-8
- US $6.68 / KG
- 97%-99%
- Career Henan Chemical Co
