EPHB6 ANTIBODY
- CAS No.
- Chemical Name:
- EPHB6 ANTIBODY
- Synonyms
- EPHB6 ANTIBODY
- CBNumber:
- CB74728569
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
EPHB6 ANTIBODY price More Price(1)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb609130 | EPHB6 antibody Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. | 100μg | $499.8 | 2021-12-16 | Buy |
| Product number | Packaging | Price | Buy |
|---|---|---|---|
| orb609130 | 100μg | $499.8 | Buy |
EPHB6 ANTIBODY Chemical Properties,Uses,Production
Source
Rabbit
Reactivity
Human
Background
EphB6 is a kinase-defective receptor and member of the ephrin-B family of transmembrane proteins. Although lacking kinase activity, EphB6 can regulate cellular functions through its interaction with adaptor proteins and other Eph family members. In hematopoietic cells, EphB6 is specifically expressed in the T cell population and functions as an important regulator of T cell receptor mediated signaling. Upon binding with its ephrin-B1 or ephrin-B2 ligand, EphB6 modulates TCR activity through inhibition of JNK signaling, reduction of CD25 expression, and decreased IL-2 secretion. Reduced levels of cell proliferation and cytokine secretion are seen in EphB6 knock-out mice relative to wild type. In conjunction with EphB3 receptor activation, EphB6 suppresses Fas receptor induced apoptosis by triggering the Akt activation pathway. Research indicates that decreased EphB6 expression is associated with a higher degree of metastasis in various cancers, including breast cancer, lung cancer, and neuroblastoma. EphB6 is thought to reduce cancer invasiveness through its effect on cell adhesion and migration. Following EphrinB1 ligand binding, EphB6 is phosphorylated by kinases such as Src and another active EphB kinase. Phosphorylated EphB6 forms a stable complex with Cbl and initiates Cbl inhibition of cell adhesion. EphB6 regulates signal transduction through direct interaction with other active Eph receptor kinases, sequestering these EphB6-bound receptors and inhibiting typical signal transduction function.
References
[1] Gurniak, C.B. and Berg, L.J. (1996) Oncogene 13, 777-86.
[2] Freywald, A. et al. (2002) J Biol Chem 277, 3823-8.
[3] Shimoyama, M. et al. (2000) Growth Factors 18, 63-78.
[4] Freywald, A. et al. (2003) J Biol Chem 278, 10150-6.
[5] Luo, H. et al. (2004) J Clin Invest 114, 1762-73.
[6] Maddigan, A. et al. (2011) J Immunol 187, 5983-94.
[7] Fox, B.P. and Kandpal, R.P. (2006) Biochem Biophys Res Commun 340, 268-76.
[8] Müller-Tidow, C. et al. (2005) Cancer Res 65, 1778-82.
[9] Tang, X.X. et al. (2000) Proc Natl Acad Sci U S A 97, 10936-41.
[10] Matsuoka, H. et al. (2005) J Biol Chem 280, 29355-63.
EPHB6 ANTIBODY Preparation Products And Raw materials
Raw materials
Preparation Products
EPHB6 ANTIBODY Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Ipodix Biotechnology Co.,Ltd. | 18007124176 19384116026 | 2706668885@qq.com | China | 4987 | 58 |
| Supplier | Advantage |
|---|---|
| Hubei Ipodix Biotechnology Co.,Ltd. | 58 |
