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1-(2-Hydroxy-5-methylphenyl)ethanone

1-(2-Hydroxy-5-methylphenyl)ethanone Structure
1-(2-Hydroxy-5-methylphenyl)ethanone structure
CAS No.
1450-72-2
Chemical Name:
1-(2-Hydroxy-5-methylphenyl)ethanone
Synonyms
Ethanone,1-(2-hydroxy-5-methylphenyl)-;o-Acetyl-p-cresol;1-(2-HYDROXY-5-METHYLPHENYL)ETHAN-1-ONE;2'-Hydroxy-5'-methylacetophenone;2-ACETYL-4-METHYLPHENOL;2-HYDROXY-5-METHYLACETOPHENONE;2-hydroxy-5,6-dimethyl acetophenone;2'EOS-61730;AURORA 16683
CBNumber:
CB7477191
Molecular Formula:
C9H10O2
Molecular Weight:
150.17
MDL Number:
MFCD00002380
MOL File:
1450-72-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:14:48
Product description Number Pack Size Price
2′-Hydroxy-5′-methylacetophenone 98% H37601 10g $48
2′-Hydroxy-5′-methylacetophenone 98% H37601 50g $228
2'-Hydroxy-5'-methylacetophenone >98.0%(GC) H0790 5g $33
2'-Hydroxy-5'-methylacetophenone >98.0%(GC) H0790 25g $100
2-Hydroxy-5-methylacetophenone Asreported 279668 5g $333
More product size
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1-(2-Hydroxy-5-methylphenyl)ethanone Properties

Melting point 45-48 °C(lit.)
Boiling point 112-114°C 12mm
Density 1.079
refractive index 1.5369 (estimate)
FEMA 4594 | 2-HYDROXY-5-METHYLACETOPHENONE
Flash point >230 °F
storage temp. Sealed in dry,Room Temperature
solubility DMSO : 50 mg/mL (332.96 mM; Need ultrasonic)
pka 10.46±0.18(Predicted)
form powder to crystal
color Light orange to Yellow to Green
Odor at 1.00 % in dipropylene glycol. sweet heavy floral herbal
Odor Type floral
Water Solubility Insoluble in water.
JECFA Number 2045
BRN 1364840
InChI 1S/C9H10O2/c1-6-3-4-9(11)8(5-6)7(2)10/h3-5,11H,1-2H3
InChIKey YNPDFBFVMJNGKZ-UHFFFAOYSA-N
SMILES Cc1ccc(O)c(c1)C(C)=O
LogP 2.52
CAS DataBase Reference 1450-72-2(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) 2-HYDROXY-5-METHYLACETOPHENONE
FDA UNII 11661U1ZEN
NIST Chemistry Reference Ethanone, 1-(2-hydroxy-5-methylphenyl)-(1450-72-2)
EPA Substance Registry System Ethanone, 1-(2-hydroxy-5-methylphenyl)- (1450-72-2)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  3
Hazard Note  Irritant
TSCA  TSCA listed
HS Code  29147000
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

1-(2-Hydroxy-5-methylphenyl)ethanone price More Price(80)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H37601 2′-Hydroxy-5′-methylacetophenone 98% 1450-72-2 10g $48 2026-04-30 Buy
Sigma-Aldrich H37601 2′-Hydroxy-5′-methylacetophenone 98% 1450-72-2 50g $228 2026-04-30 Buy
TCI Chemical H0790 2'-Hydroxy-5'-methylacetophenone >98.0%(GC) 1450-72-2 5g $33 2026-04-30 Buy
TCI Chemical H0790 2'-Hydroxy-5'-methylacetophenone >98.0%(GC) 1450-72-2 25g $100 2026-04-30 Buy
Usbiological 279668 2-Hydroxy-5-methylacetophenone Asreported 1450-72-2 5g $333 2026-06-03 Buy
Product number Packaging Price Buy
H37601 10g $48 Buy
H37601 50g $228 Buy
H0790 5g $33 Buy
H0790 25g $100 Buy
279668 5g $333 Buy

1-(2-Hydroxy-5-methylphenyl)ethanone Chemical Properties,Uses,Production

Chemical Properties

yellow crystalline powder

Uses

2'-Hydroxy-5'-methylacetophenone is used to produce 2-ethyl-4-methyl-phenol. It is used as an intermediate in organic synthesis.

Definition

ChEBI: 2'-Hydroxy-5'-methylacetophenone is an aromatic ketone.

Preparation

Obtained by treatment of methyl 4-hydroxy-6-methyl-coumarin-3-carboxylate with potassium hydroxide at 200° (82%).

Synthesis

P-TOLYL ACETATE

140-39-6

1-(2-Hydroxy-5-methylphenyl)ethanone

1450-72-2

The general procedure for the synthesis of 2-hydroxy-5-methylacetophenone from p-cresyl acetate was as follows: p-tolyl acetate (10 g, 0.067 mol) and aluminum chloride (10.7 g, 0.08 mol) were added to a 500-mL round-bottomed flask. The reaction mixture was heated in an oil bath at 140-150°C for 5-6 hours. The reaction process was monitored by thin layer chromatography (TLC) using ethyl acetate:hexane as the unfolding agent. After completion of the reaction, the reaction mixture was quenched with crushed ice and the resulting solid product was extracted with ethyl acetate (2 x 50 mL). The organic phase was washed with brine solution (2 x 15 mL) and dried with anhydrous sodium sulfate. Subsequently, the solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified by aqueous ethanol recrystallization to afford the target compound 2-hydroxy-5-methylacetophenone in 92% yield with a melting point of 45-48°C.

References

[1] Journal of Organic Chemistry, 1981, vol. 46, p. 4971 - 4975
[2] Journal of Chemical Research, Miniprint, 2003, # 12, p. 1258 - 1270
[3] Journal of Chemical Research, Synopses, 1999, # 9, p. 574 - 575
[4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 7, p. 734 - 736
[5] Journal of Chemical Research, Miniprint, 1998, # 10, p. 2678 - 2695

1-(2-Hydroxy-5-methylphenyl)ethanone synthesis

108293-71-6
1450-72-2
Synthesis of 1-(2-Hydroxy-5-methylphenyl)ethanone from Ethanone, 1-[5-methyl-2-(2-propen-1-yloxy)phenyl]-

1-(2-Hydroxy-5-methylphenyl)ethanone Preparation Products And Raw materials

Raw materials

Acetyl chloride p-Cresol Aluminum chloride Diethyl ether Pyridine
1-(2-METHOXY-5-METHYLPHENYL)ETHANONE P-TOLYL ACETATE Ethanone, 1-[5-methyl-2-(2-propen-1-yloxy)phenyl]- NSC 46633 3'-Methylacetophenone

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Preparation Products

4-Methylcatechol 4-HYDROXY-6-METHYLCOUMARIN 2,5-Dimethylbenzoxazole 1-[3-(1,1-Dimethylethyl)-2-hydroxy-5-methylphenyl]ethanone ETHYL 4-(2-HYDROXY-5-METHYL-3-NITROPHENYL)-2,4-DIOXOBUTANOATE
2-(2-Amino-thiazol-4-yl)-4-methyl-phenol

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1-(2-Hydroxy-5-methylphenyl)ethanone Suppliers

Global( 217)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+8617392709771 1097@dideu.com China 3992 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21586 55
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 9545 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52704 58
CD Chemical Group Limited 		+8615986615575 info@codchem.com China 17259 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Zhengzhou Alfa Chemical Co.,Ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
CD Chemical Group Limited 		58

View Lastest Price from 1-(2-Hydroxy-5-methylphenyl)ethanone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-(2-Hydroxy-5-methylphenyl)ethanone pictures 2025-12-24 1-(2-Hydroxy-5-methylphenyl)ethanone
1450-72-2
 $4656.00 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
1-(2-Hydroxy-5-methylphenyl)ethanone pictures 2020-01-09 1-(2-Hydroxy-5-methylphenyl)ethanone
1450-72-2
 $1.00 1KG 98% HPLC 10 tons/month Career Henan Chemical Co

1-(2-Hydroxy-5-methylphenyl)ethanone Spectrum

1-(2-Hydroxy-5-methylphenyl)ethanone(1450-72-2)MS1-(2-Hydroxy-5-methylphenyl)ethanone(1450-72-2)1HNMR1-(2-Hydroxy-5-methylphenyl)ethanone(1450-72-2)IR11-(2-Hydroxy-5-methylphenyl)ethanone(1450-72-2)IR21-(2-Hydroxy-5-methylphenyl)ethanone(1450-72-2)Raman

1450-72-2(1-(2-Hydroxy-5-methylphenyl)ethanone)Related Search:

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1-(2-hydroxy-5-methylphenyl)-ethanon 1-Hydroxy-2-acetyl-4-methylbenzene 2’-Hydroxy-5’-methylacetophenon 5’-Methyl-2’-hydroxyacetophenone Acetophenone, 2'-hydroxy-5'-methyl- Acetophenone,2’-hydroxy-5’-methyl- 1-(2-HYDROXY-5-METHYLPHENYL)ETHANONE 1-(2-HYDROXY-5-METHYLPHENYL)-1-ETHANONE 2-ACETYL-4-METHYLPHENOL 2-HYDROXY-5-METHYLACETOPHENONE AURORA 16683 ASISCHEM D38759 OTAVA-BB BB7013941401 TIMTEC-BB SBB005399 2-Hydroxy-5-methylacetophenone ,98% 1-(2-Hydroxy-5-methylphenyl)ethan-1-one, 2-Acetyl-p-cresol, 2-Acetyl-4-methylphenol EOS-61730 JR-8509, 1-(2-Hydroxy-5-methylphenyl)ethanone, 97% 2'-Hydroxy-5'-methylacetophenone> ortho-acetyl-para-cresol TIANFUCHEM--11450-72-2--1-(2-Hydroxy-5-methylphenyl)ethanone 2' -Hydroxy-5' -Hydroxy-5'-methylacetophenoe 2-hydroxy-5-methylbenzenethylone 1-(2-HYDROXY-5-METHYLPHENYL)ETHAN-1-ONE 2-hydroxy-5,6-dimethyl acetophenone 2'-Hydroxy-5'-methylacetophenone Ethanone,1-(2-hydroxy-5-methylphenyl)- o-Acetyl-p-cresol 1450-72-2 Organic Building Blocks Ketones KETONE Building Blocks Carbonyl Compounds C9 Aromatic Acetophenones & Derivatives (substituted) C9 Carbonyl Compounds Ketones