polymer
- CAS No.
- 1226999-07-0
- Chemical Name:
- polymer
- Synonyms
- Foretinib phosphate
- CBNumber:
- CB74779460
- Molecular Formula:
- C34H37F2N4O10P
- Molecular Weight:
- 730.66
- MDL Number:
- MOL File:
- 1226999-07-0.mol
- MSDS File:
- SDS
| FDA UNII | IT5CLX2ZV6 |
|---|
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H373 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P260-P314-P501 |
polymer Chemical Properties, Uses, Production
Uses
Foretinib phosphate is an orally bioavailable small molecule with potential anti-tumor activity. Foretinib phosphate can selectively inhibit hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), thereby potentially inhibiting tumor angiogenesis, tumor cell proliferation and metastasis. Foretinib phosphate shows different anti-cancer activity from cabozantinib in lung cancer cells and has stronger inhibitory effects on targets such as MEK1/2, FER and AURKB[1].
IC 50
VEGFR2
References
[1] Qian F, et al. Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res, 2009, 69(20), 8009-8016. DOI:10.1158/0008-5472.CAN-08-4889
[2] Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets DOI:10.1016/j.chembiol.2019.06.003
[3] Kataoka Y, et al. Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks. Invest New Drugs, 2011. DOI:10.1007/s10637-011-9699-0
[4] Eder JP, et al. A phase I study of foretinib, a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2. Clin Cancer Res, 2010, 16(13), 3507-3516. DOI:10.1158/1078-0432.CCR-10-0574
polymer Preparation Products And Raw materials
Raw materials
Preparation Products
polymer Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Latest Price from polymer manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Foretinib phosphate
1226999-07-0
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- Foretinib phosphate
1226999-07-0
- $1520.00-2500.00
- TargetMol Chemicals Inc.
