Dxd
- CAS No.
- 1599440-33-1
- Chemical Name:
- Dxd
- Synonyms
- Dxd (Exatecan derivative);Dxd;OQM5SD32BQ;UNII-OQM5SD32BQ;Dxd, 10 mM in DMSO;Exatecan derivative;Exatecan Impurity 4 (Dxd);Exatecan derivative for ADC;D5-Exatecan derivative for ADC;Trastuzumab Deruxtecan (DS-8201a)
- CBNumber:
- CB74796647
- Molecular Formula:
- C26H24FN3O6
- Molecular Weight:
- 493.48
- MDL Number:
- MFCD31657444
- MOL File:
- 1599440-33-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 957.9±65.0 °C(Predicted) |
|---|---|
| Density | 1.57±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:40.0(Max Conc. mg/mL);81.06(Max Conc. mM) |
| form | Solid |
| pka | 11.18±0.40(Predicted) |
| color | Off-white to yellow |
| InChIKey | PLXLYXLUCNZSAA-QLXKLKPCSA-N |
| SMILES | C(N[C@@H]1C2C3C(N=C4C5N(C(=O)C6COC(=O)[C@@](CC)(O)C=6C=5)CC4=2)=CC(F)=C(C)C=3CC1)(=O)CO |
| FDA UNII | OQM5SD32BQ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P330-P405-P501 |
Dxd price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 41699 | Dxd ≥95% | 1599440-33-1 | 10mg | $72 | 2026-04-30 | Buy |
| Cayman Chemical | 41699 | Dxd ≥95% | 1599440-33-1 | 25mg | $170 | 2026-04-30 | Buy |
| Cayman Chemical | 41699 | Dxd ≥95% | 1599440-33-1 | 50mg | $304 | 2026-04-30 | Buy |
| Cayman Chemical | 41699 | Dxd ≥95% | 1599440-33-1 | 100mg | $429 | 2026-04-30 | Buy |
| Biosynth | ZNC44033 | Dxd | 1599440-33-1 | 25mg | $519.25 | 2026-06-05 | Buy |
Dxd Chemical Properties, Uses, Production
Uses
Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).
Biological Activity
Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor with IC50 value of 0.31 μM, which can be used as a payload for an antibody-drug conjugate ADC (DS-8201a) targeting HER2.
in vitro
Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC 50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). Dxd is cytotoxic to human cancer cell lines of KPL-4, NCI-N87, SK-BR-3, and MDA-MB-468 with IC 50 s of 1.43 nM-4.07 nM, but the control IgG-ADC (Dxd is the payload) shows no inhibition on the four cell lines (with HER2 expression). DS-8201a (Dxd is the payload) displays significant suppression on the HER2-positive KPL-4, NCI-N87, and SK-BR-3 cell lines, with IC 50 values of 26.8, 25.4, and 6.7 ng/mL, respectively, but with no such inhibition on MDA-MB-468 (IC 50 , >10,000 ng/mL).
in vivo
DS-8201a (Dxd is the payload, 10 mg/kg, i.v.) shows potent antitumor activity in HER2-positive models with KPL4, JIMT-1, and Capan-1 and in HER2 low-expressing ST565 and ST313 models with HER2 IHC 1+/FISH-negative expression.
IC 50
Topoisomerase I: 0.31 μM (IC50); Camptothecins
References
[1] Ogitani Y, et al. DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1. Clin Cancer Res. 2016 Oct 15;22(20):5097-5108. DOI:10.1158/1078-0432.CCR-15-2822
Dxd Preparation Products And Raw materials
Raw materials
Preparation Products
Dxd Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Tekanbio Pharm-Tech Co., Ltd. | 021-50896099 18017206244 | sales@tekanbio.com | China | 88 | 58 |
| Levena (Suzhou) Biopharma Co., Ltd. | 0512-81877925 051281877925 | info@levena.cn | China | 48 | 58 |
| YJ Pharma | 13962794339 | Sales@yucarepharma.com | China | 294 | 58 |
| Zhejiang Huida Biotech Co., Ltd. | 0571-89903022 18679456698 | zilong@hizyme.com | China | 7853 | 58 |
| Zhejiang Boxiao Bio-Pharmaceutical Co., Ltd. | +86-571-63280982 | Helena_Huang@bx-biopharm.com | China | 47 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 | sales@sunlidabio.com | China | 3223 | 55 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 |
View Latest Price from Dxd manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-10 | Dxd
1599440-33-1
|
$39.00-97.00 | 99.49% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-08-25 | Dxd
1599440-33-1
|
$3.00-9.00 | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |||
 |
2026-07-14 | Dxd
1599440-33-1
|
$39.00-97.00 | 99.49% | 10g | TargetMol Chemicals Inc. |
