FN-1501
- CAS No.
- 1429515-59-2
- Chemical Name:
- FN-1501
- Synonyms
- FN-1501, 10 mM in DMSO;4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide;1H-Pyrazole-3-carboxamide, N-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-4-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-
- CBNumber:
- CB74796652
- Molecular Formula:
- C22H25N9O
- Molecular Weight:
- 431.49
- MDL Number:
- MFCD31657383
- MOL File:
- 1429515-59-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.427±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 50 mg/mL (115.88 mM) |
| form | Solid |
| pka | 11.73±0.70(Predicted) |
| color | White to off-white |
| FDA UNII | 6MC966B505 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
FN-1501 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | EHC51559 | FN-1501 | 1429515-59-2 | 5mg | $895.6 | 2026-06-04 | Buy |
| Biosynth | EHC51559 | FN-1501 | 1429515-59-2 | 10mg | $1194.2 | 2026-06-04 | Buy |
| Biosynth | EHC51559 | FN-1501 | 1429515-59-2 | 25mg | $2076.75 | 2026-06-04 | Buy |
| Biosynth | EHC51559 | FN-1501 | 1429515-59-2 | 50mg | $2855.5 | 2026-06-04 | Buy |
| Biosynth | EHC51559 | FN-1501 | 1429515-59-2 | 100mg | $4673 | 2026-06-04 | Buy |
FN-1501 Chemical Properties, Uses, Production
Uses
FN-1501 is a potent inhibitor of FLT3 and CDK, with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. FN-1501 has anticancer activity.
in vivo
FN-1501 exhibits potent antitumor activity, and shows little cytotoxicity on normal lymphocyte cells, with LD50 of 185.67 mg/kg in ICR mice. FN-1501 (15. 30, or 40 mg/kg/d, i.v.) dose-dependently and significantly suppresses the growth of tumor in MV4-11-cell-inoculated-xenograft mice[1].
IC 50
Cdk4/cyclin D1: 0.85 nM (IC50); CDK6/cyclinD1: 1.96 nM (IC50); cdk2/cyclin A: 2.47 nM (IC50); FLT3: 0.28 nM (IC50)
References
[1] Wang Y, et al. Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia. J Med Chem. 2018 Feb 22;61(4):1499-1518. DOI:10.1021/acs.jmedchem.7b01261
FN-1501 Preparation Products And Raw materials
Raw materials
Preparation Products
FN-1501 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Mashilabs (Shanghai) Co.,Ltd. | 19916721580 | mafarm@126.com | China | 4534 | 58 |
| Hangzhou J&H Chemical Co., Ltd. | 0571-87396432 | sales@jhechem.com | China | 14905 | 59 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2996 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2970 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9711 | 58 |
| Shanghai Yu Ben Biotechnology Co., Ltd. | 021-61350663 15502154572 | 1639466865@qq.com | China | 499 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
