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4-Aminoantipyrine

4-Aminoantipyrine structure

CAS No.: 83-07-8

Chemical Name:: 4-Aminoantipyrine

Synonyms: 4-AAP;AMPYRONE;AMINOANTIPYRINE;4-AMINOPHENAZONE;4-Amino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one;4-AMINOANTIPYRIN;4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE;4-AMINO-1,5-DIMETHYL-2-PHENYL-1,2-DIHYDRO-PYRAZOL-3-ONE;NSC 60242;Minoazophene

CBNumber:: CB7485059

Molecular Formula:: C11H13N3O

Molecular Weight:: 203.24

MDL Number:: MFCD00003145

MOL File:: 83-07-8.mol

MSDS File:: SDS

Last updated:2026-04-22 18:57:36

Product description	Number	Pack Size	Price
4-Aminoantipyrine puriss. p.a., reag. Ph. Eur., ≥99%	33528	25g	$101
4-Aminoantipyrine puriss. p.a., reag. Ph. Eur., ≥99%	33528	100g	$109
4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one GR for analysis	1.07293	10g	$79.3
4-Aminoantipyrine for spectrophotometric det. of H2O2 and phenols, ≥98.0%	06800	25g	$51
4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one GR for analysis	1.07293	100g	$370
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4-Aminoantipyrine Properties

Melting point	105-110 °C(lit.)
Boiling point	340 C
bulk density	430kg/m3
Density	0.8
refractive index	1.4930 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	H₂O: 0.1 g/mL, clear
pka	pK1: 4.94(+1) (25°C)
form	Powder or Crystals
color	Yellow to yellow-brown
Odor	Odorless
PH	7.1 (100g/l, H2O, 20℃)(slurry)
Water Solubility	ca. 500 g/L (20 ºC)
Merck	14,591
BRN	181635
Stability	Stable. May be light sensitive.
InChI	1S/C11H13N3O/c1-8-10(12)11(15)14(13(8)2)9-6-4-3-5-7-9/h3-7H,12H2,1-2H3
InChIKey	RLFWWDJHLFCNIJ-UHFFFAOYSA-N
SMILES	CN1N(c2ccccc2)C(=O)C(N)=C1C
LogP	-0.257 (est)
CAS DataBase Reference	83-07-8(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	0M0B7474RA
NIST Chemistry Reference	Aminoantipyrene(83-07-8)
EPA Substance Registry System	4-Aminoantipyrene (83-07-8)
UNSPSC Code	51384603
NACRES	NA.31

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P501

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

22-36/37/38-20/21/22

Safety Statements

26-36-36/37/39

WGK Germany

RTECS

CD2480000

8-9-23

Hazard Note

Harmful

TSCA

TSCA listed

HS Code

29331190

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

Toxicity

LD50 orally in Rabbit: 1700 mg/kg

NFPA 704

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4-Aminoantipyrine price More Price(61)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	33528	4-Aminoantipyrine puriss. p.a., reag. Ph. Eur., ≥99%	83-07-8	25g	$101	2026-03-19	Buy
Sigma-Aldrich	33528	4-Aminoantipyrine puriss. p.a., reag. Ph. Eur., ≥99%	83-07-8	100g	$109	2026-03-19	Buy
Sigma-Aldrich	1.07293	4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one GR for analysis	83-07-8	10g	$79.3	2026-03-19	Buy
Sigma-Aldrich	06800	4-Aminoantipyrine for spectrophotometric det. of H2O2 and phenols, ≥98.0%	83-07-8	25g	$51	2026-03-19	Buy
Sigma-Aldrich	1.07293	4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one GR for analysis	83-07-8	100g	$370	2026-03-19	Buy

Product number	Packaging	Price	Buy
33528	25g	$101	Buy
33528	100g	$109	Buy
1.07293	10g	$79.3	Buy
06800	25g	$51	Buy
1.07293	100g	$370	Buy

4-Aminoantipyrine Chemical Properties,Uses,Production

Chemical Properties

It is an amber to pale yellow crystalline powder. It is soluble in water, benzene, and ethanol, and only slightly soluble in diethyl ether.

Uses

4-Aminoantipyrine is a metabolite of aminopyrine, having both analgesic and anti-inflammatory properties. It readily forms metal complexes due to its amino nitrogen, a strong coordination site.
4-aminoantipyrine forms Schiff bases when treated with aldehydes/ketones, which are used in chemosensing applications.
Coupling Reagent for Trinder's reagent in colorimetric hydrogen peroxide detectionassays.
Forms highly stable dyes by coupling with Trinder's reagent in presence of Peroxidase and H2O2. Therefore suitable for use in test strip and solution diagnostics.

Application

4-aminoantipyrine is the most widely used analytical reagent for the estimation of phenol. It is used as a reagent for glucose determination in the presence of peroxidase and phenol. It is also used as indicator for trace phenol determinations in water.
Phenolic compounds were determined by buffering the sample to a pH of 10.0 and adding 4-aminoantipyrine to produce a yellow or amber colored complex in the presence of ferricyanide ion. The colour is intensified through extraction of the complex into chloroform. Measurement of this colour quantitatively determines the phenol concentration of the sample.

Definition

ChEBI: 4-aminoantipyrine is a pyrazolone, a member of the class of pyrazoles that is antipyrine substituted at C-4 by an amino group. It is a metabolite of aminopyrine and of metamizole. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antirheumatic drug, a peripheral nervous system drug, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an antipyretic, a drug metabolite and a marine xenobiotic metabolite. It is a primary amino compound and a pyrazolone. It derives from an antipyrine.

Preparation

synthesis of 4-aminoantipyrine: Antipyrine is nitrosated by sodium nitrite, reduced by ammonium bisulfite and ammonium sulfite, hydrolyzed by sulfuric acid, and finally neutralized with liquid ammonia to obtain 4-aminoantipyrine.

General Description

4-Aminoantipyrine forms heterocyclic Schiff bases, by reaction with various aldehydes and oximes. These Schiff bases form stable complexes with transition metals.

Purification Methods

It crystallises from EtOH or EtOH/ether. [Beilstein 25 III/IV 3554.]

4-Aminoantipyrine synthesis

Synthesis of 4-Aminoantipyrine from 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-3H-pyrazol-3-one

4-Aminoantipyrine Preparation Products And Raw materials

Raw materials

Ammonium bisulfite Iodine solution Sodium nitrite Antipyrine Starch paper

Sulfuric acid 2,3-dimethyl-4-nitroso-1-phenyl-3-pyrazolin-5-one

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Preparation Products

Aminopyrine N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)formamide 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-3H-pyrazol-3-one AMMONIUM ALGINATE Ramifenazone

N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3-methoxybenzamide 2-CYANO-N-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-ACETAMIDE 3-CHLORO-N-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)PROPANAMIDE AMINOPROPYLON

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4-Aminoantipyrine Suppliers

Global( 471)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	24597	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Anhuyan (Hainan) Biotechnology Co., LTD	+8618163349544	mollylucking@foxmail.com	China	3000	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16513	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21592	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29821	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Shenyang Simchoice Chemical Co.,Ltd	+86-024-23769576 +86-15040101888	sales@simchoicechem.com	China	254	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58

Supplier	Advantage
HANGZHOU LEAP CHEM CO., LTD.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Anhuyan (Hainan) Biotechnology Co., LTD	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Standardpharm Co. Ltd.	58
Shenyang Simchoice Chemical Co.,Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Hebei Yanxi Chemical Co., Ltd.	58

4-Aminoantipyrine: Analytical Reagent with Biological and Catalytic Applications
4-aminoantipyrine is a versatile compound used in phenol analysis and its Pd (II) complex catalyzes cross-coupling reactions.
Aug 13，2025

View Lastest Price from 4-Aminoantipyrine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-23	4-Aminoantipyrine 83-07-8	US $0.00 / G/KG	1G/KG	99%	1000000KG	Anhuyan (Hainan) Biotechnology Co., LTD
2026-04-23	4-Aminoantipyrine 83-07-8	US $0.00 / G/KG	1G/KG	99%	100000000KG	Anhuyan (Hainan) Biotechnology Co., LTD
2026-04-23	4-Aminoantipyrine 83-07-8	US $0.00-0.00 / g	1g	98.0%	10kg/month	WUHAN FORTUNA CHEMICAL CO., LTD

4-Aminoantipyrine
83-07-8
US $0.00 / G/KG
99%
Anhuyan (Hainan) Biotechnology Co., LTD

4-Aminoantipyrine
83-07-8
US $0.00 / G/KG
99%
Anhuyan (Hainan) Biotechnology Co., LTD

4-Aminoantipyrine
83-07-8
US $0.00-0.00 / g
98.0%
WUHAN FORTUNA CHEMICAL CO., LTD

4-Aminoantipyrine Spectrum

4-Aminoantipyrine(83-07-8)MS 4-Aminoantipyrine(83-07-8)¹HNMR 4-Aminoantipyrine(83-07-8)¹³CNMR 4-Aminoantipyrine(83-07-8)IR1 4-Aminoantipyrine(83-07-8)IR2

83-07-8(4-Aminoantipyrine)Related Search:

Cefazolin sodium salt Cefazolin Chlorodimethylphenylsilane Dimethyl ether Dimethyl fumarate

Dimethyl carbonate N,N-Dimethyl-1,4-phenylenediamine Antipyrine Dimethyl sebacate 3,4'-DIAMINODIPHENYLMETHANE

Glucosamine Propyphenazone 4,4'-Diaminodiphenylsulfone Acetaminophen Dimethyl sulfoxide

N,N-Dimethylformamide DIANTIPYRYLMETHANE EC 2.6.1.2

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Metamizole EP Impurity B 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one Metamizole Sodium Impurity 2（Minocycline EP Impurity B） 4-aminoantipirine 4-Amine-2,3-dimethyl-lphenyl-5-pyrazolone-[5],Ampyrone 4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl-3h-pyrazol-3-on AKOS BBS-00007964 AMINOANTIPYRINE AMINOANTIPYRINE, 4- AMINOANTIPYRINE REAGENT AMINOPHENYZONE 1-PHENYL-2,3-DIMETHYL-4-AMINOPYRAZOLONE 1,5-DIMETHYL-2-PHENYL-4-AMINOPYRAZOLONE 4-AMINOPHENAZONE 4-AMINOANTIPYRENE 4-AMINOANTIPYRIN 4-AMINOANTIPYRINE 4-AMINOANTIPYRINE REAGENT 4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE 4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLINE-5-ONE 4-AMINO-1,3-DIMETHYL-2-PHENYL-3-PYRAZOLONE 4-AMINO-1,5-DIMETHYL-2-PHENYL-1,2-DIHYDRO-PYRAZOL-3-ONE 4-AMINO-1,5-DIMETHYL-2-PHENYL-3H-PYRAZOL-3-ONE 4-Amino-1,5-dimethyl-2-phenyl-3-pyrazolone 1,5-dimethyl-2-phenyl-4-aminopyrazolin 4-AMINOANTIPYRINE [4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE] 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, Ampyrone 1,2-Dihydro-1,5-dimethyl-2-phenyl-4-amino-3H-pyrazol-3-one 1-Phenyl-2,3-dimethyl-4-amino-5-pyrazolone 4-Amino-2,3-dimethyl-1-phenyl-5-pyrazolone 4-Aminoantipyrine [for Biochemical Research] 4-Aminoantipyrine,98% 4-Aminoantipyrine;4-aminophenazone 4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYR-AZOL IN-5-ON R. G., REAG. PH. EUR. I 4-AMINOANTIPYRINE FREE BASE 4-AminoantipyrinePuriss 4-AminoantipyrinePuriss(4-Aminophenazone) 4-AMINOBENZENE SULFONIC ACID( Sulphanilic Acid) 4-Amino-1,5-dimethyl-2-phenyl-4-pyrazolin-3-one Aminoantipyrene 4-amino antipyirine 4-AMINOANTIPYRIDINE (AMPYRONE) AMINOANTIPYRINE, 4-(RG) 4-Aminoantipyrine,4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, Ampyrone 4-Aminoantipyrine p.a. AMINOANTIPYRINE, 4-(AMPYRONE)(RG) 4-AMINOANTIPYRINERESEARCH GRADE 1,5-Dimethyl-2-phenyl-4-aminopyrazoline 1-Phenyl-2,3-dimethyl-4-aminopyrazloone-[5] 3H-Pyrazol-3-one, 4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl- 3-Pyrazolin-5-one, 4-amino-2,3-dimethyl-1-phenyl- 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, 4-Aminophenazone (2,3-Dihydro-1,5-diMethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)aMine Minoazophene NSC 60242 (2,3-Dihydro-1,5-(diMethyl-d3)-3-oxo-2-phenyl-1H-pyrazol- 4-yl)aMine 1,2-Dihydro-1,5-(diMethyl-d3)-2-phenyl-4-aMino-3H-pyrazol-3-one 4-AMino-1,2-dihydro-1,5-(diMethyl-d3)-2-phenyl-3H-pyrazol-3-one