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Furo[3,4-b]pyridin-5(7H)-one

Furo[3,4-b]pyridin-5(7H)-one Structure
Furo[3,4-b]pyridin-5(7H)-one structure
CAS No.
5657-51-2
Chemical Name:
Furo[3,4-b]pyridin-5(7H)-one
Synonyms
4-AZAPHTHALIDE;azabenzenephthalazine;7H-furo[3,4-b]pyridin-5-one;FURO[3,4-B]PYRIDIN-5(7H)-ONE;5,7-dihydrofuro<3,4-b>pyridin-5-one;FURO[3,4-B]PYRIDIN-5(7H)-ONE/4-AZAPHTHALIDE
CBNumber:
CB7487563
Molecular Formula:
C7H5NO2
Molecular Weight:
135.12
MDL Number:
MFCD01860224
MOL File:
5657-51-2.mol
MSDS File:
SDS
Last updated:2026-05-28 03:59:33
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Furo[3,4-b]pyridin-5(7H)-one Properties

Melting point 142-144 °C
Boiling point 330.9±37.0 °C(Predicted)
Density 1.360±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka 1.81±0.20(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

Furo[3,4-b]pyridin-5(7H)-one price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Synthonix F44926 Furo[3,4-b]pyridin-5(7H)-one 95+% 5657-51-2 100mg $21 2026-05-06 Buy
Synthonix F44926 Furo[3,4-b]pyridin-5(7H)-one 95+% 5657-51-2 250mg $27 2026-05-06 Buy
Synthonix F44926 Furo[3,4-b]pyridin-5(7H)-one 95+% 5657-51-2 1g $40 2026-05-06 Buy
Synthonix F44926 Furo[3,4-b]pyridin-5(7H)-one 95+% 5657-51-2 5g $140 2026-05-06 Buy
aablocks AA0038K0 Furo[3,4-b]pyridin-5(7H)-one ≥97% 5657-51-2 100mg $10 2026-05-28 Buy
Product number Packaging Price Buy
F44926 100mg $21 Buy
F44926 250mg $27 Buy
F44926 1g $40 Buy
F44926 5g $140 Buy
AA0038K0 100mg $10 Buy

Furo[3,4-b]pyridin-5(7H)-one Chemical Properties, Uses, Production

Synthesis

2,3-Pyridinedicarboxylic anhydride

699-98-9

Furo[3,4-b]pyridin-5(7H)-one

5657-51-2

General procedure for the synthesis of furan[3,4-B]pyridin-5(7H)-one from 2,3-pyridinedicarboxylic anhydride: NaBH4 (1.14 g, 33.5 mmol) was slowly added to a solution of tetrahydrofuran (THF, 35 mL) of 2,3-pyridinedicarboxylic anhydride (5.0 g, 33.5 mmol) under argon gas protection and the temperature of the reaction was kept at 15 °C. Subsequently, acetic acid (4 g, 67 mmol) was added dropwise and the reaction mixture was stirred continuously at 15 °C for 4 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in a mixture of acetic acid (13.5 mL) and acetic anhydride (13.5 mL) and stirred at 100 °C for 3 hours. The reaction mixture was concentrated under reduced pressure and the residue was dissolved in a mixed solution of water (35 mL) and sodium chloride (6.7 g). The aqueous phase was extracted with chloroform (3 x 40 mL) and the organic layers were combined and concentrated. Finally, recrystallization by isopropanol (z'-PrOH) afforded the target compound furan[3,4-B]pyridin-5(7H)-one (2.5 g, 55% yield) as a light yellow solid with a melting point of 123-125°C. The product was detected by IR (KBr), showing characteristic absorption peaks located at 1778, 1567, 1423, 1355, 1000, 743 cm^-1 ; 1H NMR (300 MHz, CDCl3) spectrum showed δ 8.87 (dd, J = 1.5, 4.9 Hz, 1H), 8.22 (dd, J = 1.5, 7.7 Hz, 1H), and 7.50 (dd, J = 5.0, 7.8 Hz, 1H), 5.33 (s, 2H); ESIMS analysis showed m/z 136 (MH+, relative intensity 100).

References

[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 6, p. 1778 - 1782
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 8, p. 3840 - 3853
[3] Patent: WO2017/160898, 2017, A1. Location in patent: Paragraph 00104; 00120
[4] Synthesis, 1997, # 1, p. 113 - 116
[5] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981, p. 3012 - 3015

Furo[3,4-b]pyridin-5(7H)-one Preparation Products And Raw materials

Raw materials

2,3-Pyridinedicarboxylic anhydride Acetic acid Acetic anhydride Sodium borohydride

Preparation Products

Furo[3,4-b]pyridin-5(7H)-one Suppliers

Global Suppliers ( 105)
Supplier Tel Email Country ProdList Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Beijing Isomersyn Technology CO;LTD 010-82954736 13391601435 sales@isomersyn.com China 3294 57
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
Nanjing Norris-Pharm Technology Co., Ltd 13901585132 sales@norris-pharm.com China 8869 55
Shanghai Yolne Chemical Co., Ltd. 021-62960152 934678158@qq.com China 9886 55
Taizhou Tongxin Bio-Tech Co., Ltd 0523-86818997 18652728585 sales@allyrise.com China 2993 60
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
ShangHai Yuchuan Pharmaceutical Technology Co., Ltd. 02161555100 China 820 58
Supplier Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
Shanghai Hanhong Scientific Co.,Ltd. 64
Beijing Isomersyn Technology CO;LTD 57
Shanghai T&W Pharmaceutical Co., Ltd. 58
Nanjing Norris-Pharm Technology Co., Ltd 55
Shanghai Yolne Chemical Co., Ltd. 55
Taizhou Tongxin Bio-Tech Co., Ltd 60
Bide Pharmatech Ltd. 60
ShangHai Yuchuan Pharmaceutical Technology Co., Ltd. 58

View Latest Price from Furo[3,4-b]pyridin-5(7H)-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Furo[3,4-b]pyridin-5(7H)-one pictures 2020-01-03 Furo[3,4-b]pyridin-5(7H)-one
5657-51-2
 $1.00 1KG 99% 1kg-1000kg Career Henan Chemical Co

Furo[3,4-b]pyridin-5(7H)-one Spectrum

Furo[3,4-b]pyridin-5(7H)-one(5657-51-2)1HNMR

5657-51-2 (Furo[3,4-b]pyridin-5(7H)-one) Related Search:

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4-AZAPHTHALIDE FURO[3,4-B]PYRIDIN-5(7H)-ONE 5,7-dihydrofuro<3,4-b>pyridin-5-one FURO[3,4-B]PYRIDIN-5(7H)-ONE/4-AZAPHTHALIDE 7H-furo[3,4-b]pyridin-5-one azabenzenephthalazine 5657-51-2 5657-56-2