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A1874

A1874 Structure
A1874 structure
CAS No.
2064292-12-0
Chemical Name:
A1874
Synonyms
A1874;A1874 ，S8785;A-1874;A 1874;Inhibitor,PROTACs,Epigenetic Reader Domain,A-1874,inhibit,A1874,A 1874;(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-N-(4-((1-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)carbamoyl)-2-methoxyphenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamide;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, N-[1-[4-[[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxyphenyl]-1-oxo-5,8,11-trioxa-2-azatridec-13-yl]-4-(4-chlorophenyl)-2,3,9-trimethyl-...;(6S)-N-[1-[4-[[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxyphenyl]-1-oxo-5,8,11-trioxa-2-azatridec-13-yl]-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide;(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-N-[4-[2-[2-[2-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]ethoxy]ethoxy]ethylcarbamoyl]-2-methoxyphenyl]-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carboxamide
CBNumber:
CB74890866
Molecular Formula:
C58H62Cl3F2N9O7S
Molecular Weight:
1173.59
MDL Number:
MFCD31813733
MOL File:
2064292-12-0.mol
Last updated:2025-12-16 16:15:04
Product description Number Pack Size Price
A1874 98.38% CS-0082007 10mg $950
A1874 >98% orb611292 100mg $1431.4
A1874 98.38% CS-0082007 5mg $650
A1874 98.38% CS-0082007 25mg $1950
A1874 >98% orb611292 250mg $2395.3
Request For Quotation

A1874 Properties

storage temp. Store at -20°C
solubility DMSO:125.0(Max Conc. mg/mL);106.51(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);85.21(Max Conc. mM)
form Solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

A1874 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0082007 A1874 98.38% 2064292-12-0 10mg $950 2021-12-16 Buy
Biorbyt Ltd orb611292 A1874 >98% 2064292-12-0 100mg $1431.4 2021-12-16 Buy
ChemScene CS-0082007 A1874 98.38% 2064292-12-0 5mg $650 2021-12-16 Buy
ChemScene CS-0082007 A1874 98.38% 2064292-12-0 25mg $1950 2021-12-16 Buy
Biorbyt Ltd orb611292 A1874 >98% 2064292-12-0 250mg $2395.3 2021-12-16 Buy
Product number Packaging Price Buy
CS-0082007 10mg $950 Buy
orb611292 100mg $1431.4 Buy
CS-0082007 5mg $650 Buy
CS-0082007 25mg $1950 Buy
orb611292 250mg $2395.3 Buy

A1874 Chemical Properties,Uses,Production

Uses

A1874 is a nutlin-based (MDM2 ligand) and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation[1].

IC 50

BRD4

References

[1] Hines J, et al. MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53. Cancer Res. 2019 Jan 1;79(1):251-262. DOI:10.1158/0008-5472.CAN-18-2918

A1874 Preparation Products And Raw materials

Raw materials

Preparation Products

A1874 Suppliers

Global( 45)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32436 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39035 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7778 56
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4782 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71826 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62

View Lastest Price from A1874 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
A1874 pictures 2025-12-16 A1874
2064292-12-0
 US $84.00-372.00 / mg 99.52% 10g TargetMol Chemicals Inc.
  • A1874 pictures
  • A1874
    2064292-12-0
  • US $84.00-372.00 / mg
  • 99.52%
  • TargetMol Chemicals Inc.

A1874 Spectrum

A1874(2064292-12-0)1HNMR
A1874 A-1874;A 1874 (6S)-N-[1-[4-[[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxyphenyl]-1-oxo-5,8,11-trioxa-2-azatridec-13-yl]-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, N-[1-[4-[[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxyphenyl]-1-oxo-5,8,11-trioxa-2-azatridec-13-yl]-4-(4-chlorophenyl)-2,3,9-trimethyl-... (2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-N-[4-[2-[2-[2-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]ethoxy]ethoxy]ethylcarbamoyl]-2-methoxyphenyl]-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carboxamide (2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-N-(4-((1-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)carbamoyl)-2-methoxyphenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamide Inhibitor,PROTACs,Epigenetic Reader Domain,A-1874,inhibit,A1874,A 1874 A1874 ，S8785 2064292-12-0 C58H62Cl3F2N9O7S