4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide
- CAS No.
- 1884640-99-6
- Chemical Name:
- 4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide
- Synonyms
- NI-42 >=98% (HPLC);NI-42, 10 mM in DMSO;BRPF1 inhibitor NI-42;NI-42,Inhibitor,inhibit,NI 42,Epigenetic Reader Domain,NI42;4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide;4-Cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide;Benzenesulfonamide, 4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-
- CBNumber:
- CB74902796
- Molecular Formula:
- C18H15N3O3S
- Molecular Weight:
- 353.39
- MDL Number:
- MFCD30290161
- MOL File:
- 1884640-99-6.mol
| Product description | Number | Pack Size | Price |
| NI-42 | 28293 | 5mg | $93 |
| NI-42 | 28293 | 25mg | $381 |
| NI-42 | 28293 | 1mg | $32 |
| NI-42 | 28293 | 10mg | $169 |
| NI42 | N900610 | 1mg | $90 |
| Boiling point | 554.6±60.0 °C(Predicted) |
|---|---|
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml |
| form | A crystalline solid |
| pka | 8.05±0.20(Predicted) |
| color | white to beige |
| InChI | InChI=1S/C18H15N3O3S/c1-12-9-14-10-15(5-8-17(14)21(2)18(12)22)20-25(23,24)16-6-3-13(11-19)4-7-16/h3-10,20H,1-2H3 |
| InChIKey | BMVCSXFOQPYKKC-UHFFFAOYSA-N |
| SMILES | C1(S(NC2C=CC3=C(C=2)C=C(C)C(=O)N3C)(=O)=O)=CC=C(C#N)C=C1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28293 | NI-42 | 1884640-99-6 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 28293 | NI-42 | 1884640-99-6 | 25mg | $381 | 2024-03-01 | Buy |
| Cayman Chemical | 28293 | NI-42 | 1884640-99-6 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 28293 | NI-42 | 1884640-99-6 | 10mg | $169 | 2024-03-01 | Buy |
| TRC | N900610 | NI42 | 1884640-99-6 | 1mg | $90 | 2021-12-16 | Buy |
4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide Chemical Properties,Uses,Production
Description
NI-42 is an inhibitor of the bromodomain and PHD finger-containing 1 (BRPF1) bromodomain (IC50 = 7.9 nM). It is selective for BRPF1 over BRPF2/BRD1, BRPF3, BRD9, and BRD4/BD1 (IC50s = 48, 260, 310, and 4,500 nM, respectively). NI-42 inhibits the growth of OCI-AML2, Nomo-1, THP-1, KG-1, and MV-4-11 acute myeloid leukemia (AML) cells (GI50s = 1.3, 4.6, 5.7, 7, and 9.9 μM, respectively) and a variety of non-AML cells (GI50s = 1-10 μM). It also inhibits the growth of DMS114 lung, HRA-19 colon, and RERF-LC-Sq1 lung cancer cells (GI50s = 16.6, 15.6, and 17.1 μM, respectively) but not NCI H1703 lung cancer cells (GI50 = >30 μM).
Uses
NI-42 is a new chemical probe for the BRPFs (bromodomain and PHD finger-containing) suitable for cellular and invivo studies to explore the fundamental biology of these proteins.
IC 50
BRPF1: 7.9 nM (IC50); BRPF2: 48 nM (IC50); BRPF3: 260 nM (IC50); BRPF1: 40 nM (Kd); BRPF2: 210 nM (Kd); BRPF3: 940 nM (Kd); BRD4 (BD1): 4500 nM (IC50); BRD7: 82 nM (IC50); BRD9: 310 nM (IC50); BRD9: 1130 nM (Kd)
References
[1] NIALL IGOE. Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies[J]. Journal of Medicinal Chemistry, 2017, 60 2: 668-680. DOI: 10.1021/acs.jmedchem.6b01583
[2] NIALL IGOE. Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins[J]. Journal of Medicinal Chemistry, 2017, 60 16: 6998-7011. DOI: 10.1021/acs.jmedchem.7b00611
4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide Preparation Products And Raw materials
Raw materials
Preparation Products
4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9629 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 8510 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Maiev Biotech Co.,Ltd | +86-13671830408 | maievbiotech2@163.com | China | 79 | 58 |
