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5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole

5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole structure

CAS No.: 97963-62-7

Chemical Name:: 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole

Synonyms: 5-DIFLUOROMETHOXY-2-MERCAPTO-1H-BENZIMIDAZOLE;5-(DifluoroMethoxy)-1H-benzo[d]iMidazole-2-thiol;5-Difluormethoxy-2-Mercapto-1-H-Benimidazole;Pantoprazole-3;5-(Difluoromethoxy)-2-mercapto-1H-;5-(DIFLUOROMETHOXY)-2-MERCAPTOBENZIMIDAZOLE;5-(Difluoromethoxy)-1,3-dihydro-2H-benzo[d]imidazole-2-thione;SKA 47;5-Difluoro;BUTTPARK 16\03-28

CBNumber:: CB7493780

Molecular Formula:: C8H6F2N2OS

Molecular Weight:: 216.21

MDL Number:: MFCD00467504

MOL File:: 97963-62-7.mol

MSDS File:: SDS

Last updated:2026-05-28 04:45:44

Product description	Number	Pack Size	Price
Pantoprazole Related Compound C pharmaceutical secondary standard, certified reference material	PHR3075	50MG	$382
5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole 97%	542210	5g	$96.5
Pantoprazole Related Compound C United States Pharmacopeia (USP) Reference Standard	1494920	20mg	$1290
5-(Difluoromethoxy)-2-mercaptobenzimidazole >98.0%(HPLC)(T)	D3438	25g	$31
5-(Difluoromethoxy)-1H-benzimidazole-2-thiol	064137	500.00mg	$315
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5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole Properties

Melting point	239-243 °C(lit.)
Boiling point	303.5±52.0 °C(Predicted)
Density	1.52±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	9.77±0.30(Predicted)
color	Pale Yellow
InChI	InChI=1S/C8H6F2N2OS/c9-7(10)13-4-1-2-5-6(3-4)12-8(14)11-5/h1-3,7H,(H2,11,12,14)
InChIKey	HJMVPNAZPFZXCP-UHFFFAOYSA-N
SMILES	C1(=S)NC2=CC=C(OC(F)F)C=C2N1
CAS DataBase Reference	97963-62-7(CAS DataBase Reference)
FDA UNII	39P59C89NV
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-36/37

WGK Germany

HazardClass

IRRITANT

HS Code

29339900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

REACH Registrations

Active

NFPA 704

	1
2		0

5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR3075	Pantoprazole Related Compound C pharmaceutical secondary standard, certified reference material	97963-62-7	50MG	$382	2026-04-30	Buy
Sigma-Aldrich	542210	5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole 97%	97963-62-7	5g	$96.5	2026-04-30	Buy
Sigma-Aldrich	1494920	Pantoprazole Related Compound C United States Pharmacopeia (USP) Reference Standard	97963-62-7	20mg	$1290	2026-04-30	Buy
TCI Chemical	D3438	5-(Difluoromethoxy)-2-mercaptobenzimidazole >98.0%(HPLC)(T)	97963-62-7	25g	$31	2026-04-30	Buy
Matrix Scientific	064137	5-(Difluoromethoxy)-1H-benzimidazole-2-thiol	97963-62-7	500.00mg	$315	2026-05-18	Buy

Product number	Packaging	Price	Buy
PHR3075	50MG	$382	Buy
542210	5g	$96.5	Buy
1494920	20mg	$1290	Buy
D3438	25g	$31	Buy
064137	500.00mg	$315	Buy

5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Solid

Uses

Pantoprazole EP Impurity C. Pantoprazole USP Related Compound C.

General Description

5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole may be used in the synthesis of pantoprazole, a drug for treating gastroesophageal reflux disease and gastrointestinal disorders.

Synthesis

75-15-0

172282-50-7

5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole

97963-62-7

In a four-necked flask equipped with a mechanical stirrer, a reflux condenser and a thermometer, the alkaline solution was prepared: 6.6 g of sodium carbonate was dissolved in 20 g of tap water, stirred until completely dissolved, cooled slightly, and then 34.8 g of 4-(difluoromethoxy)benzene-1,2-diamine was added, stirring was continued for 20 minutes. The reaction mixture was heated to 30°C and 20 g of carbon disulfide was slowly added dropwise, controlling the dropwise temperature at 25-35°C. After the dropwise addition was completed, the temperature was raised to 30-40°C and the condensation reaction was maintained at this temperature for 6 hours. Subsequently, continue heating to 60-70°C and maintain this temperature for cyclization for 6 hours. After the reaction was completed, activated carbon was added for decolorization. The pH of the filtrate was adjusted to 5-6 with sulfuric acid, and after filtration, washing and drying, 33.2 g of 5-difluoromethoxy-2-mercapto-1H-benzimidazole was obtained in 95.4% yield (based on 4-(difluoromethoxy)benzene-1,2-diamine).

References

[1] Patent: CN103539746, 2016, B. Location in patent: Paragraph 0037; 0038
[2] Advanced Synthesis and Catalysis, 2018, vol. 360, # 21, p. 4161 - 4167

5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole Preparation Products And Raw materials

Raw materials

Carbon disulfide Pantoprazole Impurity 11 Sodium carbonate

Preparation Products

5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole Suppliers

Global( 560)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Kindchem(Nanjing)Co.,Ltd	+86-025-025-85281586 +8618651653755	sales@kindchem.cn	China	1226	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5231	58
Firsky International Trade (Wuhan) Co., Ltd	+8615387054039	admin@firsky-cn.com	China	427	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	973	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21587	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6366	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58

Supplier	Advantage
Kindchem(Nanjing)Co.,Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Firsky International Trade (Wuhan) Co., Ltd	58
Henan Bao Enluo International TradeCo.，LTD	58
Anhui Ruihan Technology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Shandong chuangyingchemical Co., Ltd.	58

View Lastest Price from 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-29	5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole 97963-62-7		1kg	99%min	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-05-28	5- (Difluoromethoxy) -2-Mercapto-1h-Benzimidazole 97963-62-7	$2.00-5.00	1KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD
2026-05-05	5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole 97963-62-7	$90.00-900.00	10kg	0.99	20tons	Zibo Hangyu Biotechnology Development Co., Ltd

5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
97963-62-7
$0.00
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

5- (Difluoromethoxy) -2-Mercapto-1h-Benzimidazole
97963-62-7
$2.00-5.00
99%
Hebei Chuanghai Biotechnology Co,.LTD

5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
97963-62-7
$90.00-900.00
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole Spectrum

5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole(97963-62-7)¹HNMR 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole(97963-62-7)IR

97963-62-7(5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole)Related Search:

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Phenformin 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole 2-(Trifluoromethoxy)aniline tert-Butyl 4-(4-nitropyridin-3-yl)piperazine-1-carboxylate 5-Methyl-3,4-diphenylisoxazole

4-(5-methyl-4-phenylisoxazol-3-yl)benzenesulfonamide Parecoxib Impurity H Parecoxib Impurity 16 Parecoxib Impurity 18 Parecoxib Impurity 20

Parecoxib Impurity 14 Parecoxib Impurity 16 Parecoxib Impurity 13

1of4

Pantoprazole-3 5-DIFLUOROMETHOXY - 2 - MERCAPTO - 1H BE 5-(Difluoromethoxy)-2-mercapto-1H-benz 5-Difluormethoxy-2-Mercapto-1-H-Benimidazole Difluoromethoxy thio benzimidazole 5-(DifloroMethoxy)-2-Mercapto-1H-benziMidazole Pantoprazole Related Compound C (20 mg) (5-(difluoromethoxy)-1H-benzimidazole-2-thiol) 5-(DifluoroMethoxy)- Pantoprazole Related CoMpound C Pantoprazole EP IMpurity C 5-(difluoroMethoxy)-1H-1,3-benzodiazole-2-thiol 5 - two fluorine Methoxy - 2 - Mercapto - 1 h - benzene and iMidazole SKA 47 5-Difluormethoxy-2-mercaepto-1H-benzimidazole BUTTPARK 16\03-28 5-DIFLUORMETHOXY-2-MERCAPTO-1-1-1-BENZIMIDAZOLE 5-DIFLUORMETHOXY-2-MERCAPTO-1-H-BENZIMIDAZOLE 5-(DIFLUOROMETHOXY)-2-BENZIMIDAZOLETHIOL 5-DIFLUOROMETHOXY-2-THIO-BENZIMIDAZOLE 5-(DIFLUOROMETHOXY)-2-MERCAPTO-1H-BENZI 1H-2-MERCAPTO-5-(DIFLUORO METHOXY) BENZIMIDAZOLE ≥98% 5-Difuormethoxy-2-Mercapto-1-H-Benzinmidazole 5-(Difluoromethoxy)-2-Mercapto-1H-Enzimidazole 5-Difluoromethoxy-2-mercapto-1H-Benzimidazole(Pantoprazole Intermediate 5-Difluormethoxy-2-Mercapto-1H-Benzinmidazole 5-Difluoro 5-Difluoromethoxy-2-mercapto-1H-benzimidazole 99% 5-Difluoromethoxy-2-mercapto-1H-benzimidazole99% 1H-2-mercapto-5-(difluoro methoxy)benzimidazole 2-Mercapto 5-Difluoromethoxy-1H-benzimidazole 5-(difluoromethoxy)-1,3-dihydrobenzimidazole-2-thione pantoprazole benzmimdazole Pantoprazole Impurity 3(Pantoprazole EP Impurity C) 5-Difluromethoxy-2-Mercapto Benzimidazole 5-DIFLUORO-2-MERCAPTO-H BENZIMIDAZOLE Difluoromethoxy mercaptobenzimidazole 5-(Difluoromethoxy)-2-mercaptobenzimidazole> 5-(Difluoromethoxy)-1H-benzimidazol Pantoprazole sodium impurity C Pantoprazole Mercapto Compound 2H-Benzimidazole-2-thione, 5-(difluoromethoxy)-1,3-dihydro- 5 DIFLORO METHOXY 2 MERCAPTO BENZIMIDAZOLE 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole ISO 9001：2015 REACH Pantoprazole intermediates，5-Difluoromethoxy-2-mercapto-1H- benzimidazole 5-(Difluoromethoxy)-2- mercapto-1H benzimidazole5-(Difluoromethoxy)-2- mercapto-1H benzimidazole 1-H-2-mercapto-5-difluoromethoxylbenzimidazole 5-Difluoromethoxy-2-mercapto-1-H-Benzimidazole (Panto BZL) 5-difluoromethoxy - 2-mercaptoxy - 1h-benzimidazole 5-(Difluoromethoxy)-1,3-dihydro-2H-benzo[d]imidazole-2-thione (Pantoprazole Impurity) Pantoprazole EP Impurity C/ Pantoprazole Related Compound C (Pantoprazole Thiol Impurity) 5-(Difluoro methoxy)-2-mercapto-1H-benzimidazoleQ: What is 5-(Difluoro methoxy)-2-mercapto-1H-benzimidazole Q: What is the CAS Number of 5-(Difluoro methoxy)-2-mercapto-1H-benzimidazole Q: What is the storage condition of 5-(Difluoro methoxy)-2-mercapto-1H-benzimidazole Q: What are the applications of 5-(Difluoro methoxy)-2-mercapto-1H-benzimidazole Pantoprazole Related Compound C (5-(difluoromethoxy)-1H-benzimidazole-2-thiol) (1494920) 5-difluoromethoxy-2-mercapto1-hydrobenzimidazole Pantoprazole Sodium Sesquihydrate Impurity C Pantoprazole Sodium Sesquihydrate EP Impurity C Pantoprazole USP Related Compound C 5-(Difluoromethoxy)-2-mercapto-1H- benzimidazole?(BZL) 5-(DIFLUOROMETHOXY)-2-MERCAPTO-1H-BENZIMIDAZOLE (PANTO MERCAPTO)