4-(4,4-Dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-trifluoromethylbenzonitrile

4-(4,4-Dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-trifluoromethylbenzonitrile structure

CAS No.: 143782-28-9

Chemical Name:: 4-(4,4-Dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-trifluoromethylbenzonitrile

Synonyms: Enzalutamide Impurity09;2-(trifluoromethyl)-4-(4,4-dimethyl 5-oxo-2-thioimidazolin-1-yl)benzonitrile;4-(4,4-Dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-trifluoromethylbenzonitril;4-(4,4-Dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-trifluoromethylbenzonitrile;Benzonitrile, 4-(4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-(trifluoromethyl)-

CBNumber:: CB75478496

Molecular Formula:: C13H10F3N3OS

Molecular Weight:: 313.3

MDL Number:

MOL File:: 143782-28-9.mol

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4-(4,4-Dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-trifluoromethylbenzonitrile Properties

Boiling point	407.3±55.0 °C(Predicted)
Density	1.48±0.1 g/cm3(Predicted)
pka	10.40±0.40(Predicted)

4-(4,4-Dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-trifluoromethylbenzonitrile Chemical Properties,Uses,Production

Uses

4-(4,4-Dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-trifluoromethylbenzonitrile is used in the preparation of MDV 3100 (Enzalutamide)(M199800) which is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.

4-(4,4-Dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-trifluoromethylbenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

4-(4,4-Dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-trifluoromethylbenzonitrile Suppliers

Global( 3)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Changyan Chem & Tech Co., Ltd.	021-20242659 18930833303	sales@changyanchem.cn	China	4999	55
Guangzhou Viocon Pharmaceutical Technology Co., Ltd	+86-13424074264; 13726739909	chenhuini@cti-cert.com	China	500	58

Supplier	Advantage
Shanghai Changyan Chem & Tech Co., Ltd.	55
Guangzhou Viocon Pharmaceutical Technology Co., Ltd	58

4-(4,4-Dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-trifluoromethylbenzonitrile 4-(4,4-Dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-trifluoromethylbenzonitril Benzonitrile, 4-(4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-(trifluoromethyl)- Enzalutamide Impurity09 2-(trifluoromethyl)-4-(4,4-dimethyl 5-oxo-2-thioimidazolin-1-yl)benzonitrile 143782-28-9