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Zavegepant

Zavegepant structure

CAS No.: 1337918-83-8

Chemical Name:: Zavegepant

Synonyms: BHV-3500;Zavegepant;Vazegepant;Zevagepant;BMS 742413);Vazegepant free base;Zavegepant (Vazegepant;Zavegepant (BHV-3500, BMS-742413);(R)-N-(3-(7-Methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide;N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl]-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide

CBNumber:: CB75551430

Molecular Formula:: C36H46N8O3

Molecular Weight:: 638.8

MDL Number:: MFCD27938555

MOL File:: 1337918-83-8.mol

Last updated:2025-07-08 16:52:38

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Zavegepant Properties

Boiling point	933.7±65.0 °C(Predicted)
Density	1.285±0.06 g/cm3(Predicted)
pka	11.68±0.70(Predicted)
form	Solid
color	White to off-white
InChIKey	JJVAPHYEOZSKJZ-JGCGQSQUSA-N
SMILES	N1(C(N[C@H](CC2C=C(C)C3=C(C=2)C=NN3)C(N2CCN(C3CCN(C)CC3)CC2)=O)=O)CCC(C2=CC3=C(NC2=O)C=CC=C3)CC1
FDA UNII	ODU3ZAZ94J

Zavegepant Chemical Properties,Uses,Production

Description

Zavegepant, also known as Vazegepant, BHV-3500 and BMS 742413, is a highly potent, selective and structurally unique small molecule CGRP receptor antagonist. Vazegepant is the first and only CGRP receptor antagonist for intranasal administration currently in development for the acute treatment of migraine.

Uses

Vazegepant (Zavegepant) is an orally active calcitonin gene-related peptide CGRP receptor antagonist with potential for acute research in migraine, can be administered intranasally. CGRP is an important trigger in migraine pathophysiology[1][2][3][4].

brand name

Zavzpret

Mechanism of action

Zavegepant is a calcitonin gene-related peptide (CGRP) receptor antagonist used for the acute treatment of migraine. The pathophysiology of migraine has not been fully elucidated; however, specific vasoactive substances and neurotransmitters such as CGRP, neurokinin A, nitric oxide, and substance P may participate in the neurovascular and cortical spreading depression mechanisms.

Side effects

Zavegepant is generally well tolerated with side effects of dysgeusia, nausea, vomiting, and nasal discomfort that are generally transient and mild-to-moderate in severity.

References

[1] Moreno-Ajona D, et al. Gepants, calcitonin-gene-related peptide receptor antagonists: what could be their role in migraine treatment? Curr Opin Neurol. 2020 Jun;33(3):309-315. DOI:10.1097/WCO.0000000000000806
[2] Gene M Dubowchik, et al. Blocking the CGRP Pathway for Acute and Preventive Treatment of Migraine: The Evolution of Success. DOI:10.1021/acs.jmedchem.9b01810
[3] Capi M, De Angelis V, De Bernardini D, et al. Zavegepant[M]//Novel Synthetic Drugs in Migraine. Cham: Springer International Publishing, 2022: 67-72.
[4] Jéssica Barreto Ribeiro Dos Santos, et al. Small-molecule CGRP receptor antagonists: A new approach to the acute and preventive treatment of migraine. Eur J Pharmacol.2022 May 5:922:174902. DOI:10.1016/j.ejphar.2022.174902

Zavegepant synthesis

Synthesis of Zavegepant from 1H-Indazole-5-propanoic acid, α-[[[4-(1,2-dihydro-2-oxo-3-quinolinyl)-1-piperidinyl]carbonyl]amino]-7-methyl-, (αR)- and 1-(1-Methyl-4-piperidinyl)piperazine

Zavegepant Preparation Products And Raw materials

Raw materials

Preparation Products

Zavegepant Suppliers

Global( 68)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan JiyunZen Tech Co., Ltd.	+86-18062099985	Amyjiyunzen@yeah.net	China	663	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	7030	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49733	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5745	58
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	info@finetechnology-ind.com	China	9629	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com	China	10473	58
Chemtour Biotech Co., Ltd	+8617327281506	market@chemtour.com	China	1521	58
Shandong Hanjiang Chemical Co., Ltd	+86-0533-2066820 +8618369939125	hanson@sdhanjiang.com	China	1943	58
R&D Scientific Inc.	+1-2266000236	sales@rdscientific.com	Canada	1840	58

Supplier	Advantage
Wuhan JiyunZen Tech Co., Ltd.	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Jinan Carbotang Biotech Co.,Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Finetech Industry Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
Chemtour Biotech Co., Ltd	58
Shandong Hanjiang Chemical Co., Ltd	58
R&D Scientific Inc.	58

Zavegepant:Class,Uses,Mechanism of Action and Side effects
Zavegepant, sold under the brand name Zavzpret, is a medication used for the treatment of migraine.
Jun 26，2025

View Lastest Price from Zavegepant manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-08-01	Zavegepant 1337918-83-8	US $5.00-0.50 / KG	1KG	99% hplc	500TONS	Wuhan JiyunZen Tech Co., Ltd.
	2025-07-08	Vazegepant 1337918-83-8	US $2.20-8.80 / KG	1KG	99%	g-kg-tons	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Zavegepant
1337918-83-8
US $5.00-0.50 / KG
99% hplc
Wuhan JiyunZen Tech Co., Ltd.

Vazegepant
1337918-83-8
US $2.20-8.80 / KG
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

1-Piperidinecarboxamide, 4-(1,2-dihydro-2-oxo-3-quinolinyl)-N-[(1R)-1-[(7-methyl-1H-indazol-5-yl)methyl]-2-[4-(1-methyl-4-piperidinyl)-1-piperazinyl]-2-oxoethyl]- Vazegepant free base BHV-3500 Vazegepant Zavegepant Zavegepant (BHV-3500, BMS-742413) Zevagepant Zavegepant (Vazegepant BMS 742413) (R)-N-(3-(7-Methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl]-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide 1337918-83-8 API