BDNF antibody

CAS No.
Chemical Name:
BDNF antibody
Synonyms
CBNumber:
CB75607683
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

BDNF antibody price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biorbyt Ltd orb48289 BDNF antibody Affinity purification 50μl $316.2 2021-12-16 Buy
Biorbyt Ltd orb153555 BDNF antibody Affinity purified 100μL $370.6 2021-12-16 Buy
Biorbyt Ltd orb48289 BDNF antibody Affinity purification 100μL $384.2 2021-12-16 Buy
Biorbyt Ltd orb378576 BDNF antibody Peptide affinity purified 100μL $399.5 2021-12-16 Buy
Biorbyt Ltd orb379469 BDNF antibody ProA affinity purified 100μL $399.5 2021-12-16 Buy
Product number Packaging Price Buy
orb48289 50μl $316.2 Buy
orb153555 100μL $370.6 Buy
orb48289 100μL $384.2 Buy
orb378576 100μL $399.5 Buy
orb379469 100μL $399.5 Buy

BDNF antibody Chemical Properties, Uses, Production

Source

Rabbit

Reactivity

Human;Mouse

Background

Neurotrophins are composed of at least four family members, including NGF, BDNF, NT-3, and NT-4, and all are known to influence growth, development, differentiation, and survival of neurons. Proneurotrophins bind to p75NTR, but not to the family of Trk receptor tyrosine kinases, and following maturation, BDNF binds and activates TrkB. Trk receptors, in turn, activate three major signaling pathways: Ras-MAPK signaling, which promotes neuronal differentiation and neurite outgrowth, PI3K/Akt signaling, which promotes survival and growth of neurons, and PLC-γ1-PKC signaling, which promotes synaptic plasticity. BDNF is a major regulator of transmission and plasticity at adult synapses. Moreover, the precursor proBDNF and the mature protein mBDNF drive opposite effects on long-term potentiation and long-term depression. BDNF has also been implicated in body weight regulation and activity: heterozygous BDNF knockout mice are hyperphagic, obese, and hyperactive.

References

[1] Minichiello, L. and Klein, R. (1996) Genes Dev 10, 2849-58.
[2] Reichardt, L.F. (2006) Philos Trans R Soc Lond B Biol Sci 361, 1545-64.
[3] Martinowich, K. et al. (2007) Nat Neurosci 10, 1089-93.
[4] Kernie, S.G. et al. (2000) EMBO J 19, 1290-300.

BDNF antibody Preparation Products And Raw materials

Raw materials

Preparation Products