ENSA Antibody
- CAS No.
- Chemical Name:
- ENSA Antibody
- Synonyms
- ENSA Antibody;Rabbit Polyclonal ENSA Antibody
- CBNumber:
- CB75729334
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
ENSA Antibody price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb156739 | ENSA antibody Affinity purified by Protein A | 100μg | $421.6 | 2021-12-16 | Buy | |
| Biorbyt Ltd | orb28359 | ENSA antibody Peptide affinity purified. | 400μl | $525.3 | 2021-12-16 | Buy | |
| Biorbyt Ltd | orb156739 | ENSA antibody Affinity purified by Protein A | 200μg | $673.2 | 2021-12-16 | Buy |
ENSA Antibody Chemical Properties,Uses,Production
Source
Rabbit
Reactivity
Human;Monkey
Background
Mitotic control is important for normal growth, development, and maintenance of all eukaryotic cells. Research studies have demonstrated that inappropriate control of mitosis can lead to genomic instability and cancer. A regulator of mitosis, Greatwall kinase, was first identified in Drosophila melanogaster. Subsequent studies showed that, based on sequence homology and function, microtubule-associated serine/threonine kinase-like is the human ortholog of Gwl. Regulation of MASTL/Gwl activation has been shown to be critical for the correct timing of mitosis. Research studies have shown that Gwl is activated by hyperphosphorylation. The phosphorylation of human Gwl at Thr194 and Thr207 by active cyclin B1-cdc2 leads to possible autophosphorylation at Ser875, which stabilizes the kinase. Activated Gwl phosphorylates α-Endosulfine and cAMP-regulated phosphoprotein 19 at Ser67 and Ser62, respectively. Phosphorylated ENSA and ARPP19 inhibit the activity of the B55 subunit-associated form of protein phosphatase 2A, allowing for complete phosphorylation of mitotic substrates by cyclin B1-cdc2 and mitotic entry. When Gwl is inactivated, PP2A-B55 reactivates, which leads to dephosphorylation of cyclin B1-cdc2 and mitotic exit.
References
[1] Eichhorn, P.J. et al. (2009) Biochim Biophys Acta 1795, 1-15.
[2] Norbury, C. and Nurse, P. (1992) Annu Rev Biochem 61, 441-70.
[3] Yu, J. et al. (2004) J Cell Biol 164, 487-92.
[4] Voets, E. and Wolthuis, R.M. (2010) Cell Cycle 9, 3591-601.
[5] Blake-Hodek, K.A. et al. (2012) Mol Cell Biol 32, 1337-53.
[6] Vigneron, S. et al. (2011) Mol Cell Biol 31, 2262-75.
[7] Lorca, T. and Castro, A. (2012) Oncogene 32, 537-543.
ENSA Antibody Preparation Products And Raw materials
Raw materials
Preparation Products
ENSA Antibody Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Ipodix Biotechnology Co.,Ltd. | 18007124176 19384116026 | 2706668885@qq.com | China | 4987 | 58 |
| Supplier | Advantage |
|---|---|
| Hubei Ipodix Biotechnology Co.,Ltd. | 58 |
