A-395 (hydrochloride)
- CAS No.
- Chemical Name:
- A-395 (hydrochloride)
- Synonyms
- A-395 (hydrochloride)
- CBNumber:
- CB76197291
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
A-395 (hydrochloride) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20257 | A-395 (hydrochloride) ≥98% | 1mg | $41 | 2026-04-30 | Buy | |
| Cayman Chemical | 20257 | A-395 (hydrochloride) ≥98% | 5mg | $186 | 2026-04-30 | Buy | |
| Cayman Chemical | 20257 | A-395 (hydrochloride) ≥98% | 10mg | $351 | 2026-04-30 | Buy |
A-395 (hydrochloride) Chemical Properties, Uses, Production
Description
A-395 is an inhibitor of the interaction between embryonic ectoderm development (EED) and histone H3 lysine 27 (H3K27) that binds to the EED subunit of polycomb repressor complex 2 (PRC2) and inhibits H3K27 methylation (Ki = 0.4 nM).1 It inhibits H3K27 di- and trimethylation in RD rhabdoid tumor cells (IC50s = 390 and 90 nM, respectively). In vivo, A-395 (200 mg/kg) reduces tumor volume and intratumor H3K27 trimethylation in a Pfeiffer diffuse large B cell lymphoma (DLBCL) mouse xenograft model. See the Structural Genomics Consortium (SGC) website for more information.WARNING This product is not for human or veterinary use.
References
[1] YUPENG HE. The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex[J]. Nature chemical biology, 2017, 13 4: 389-395. DOI: 10.1038/nchembio.2306
A-395 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
A-395 (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Hongye Biotechnology Co. Ltd | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
