2-HYDROXY-5-BENZYLOXYACETOPHENONE
- CAS No.
- 30992-63-3
- Chemical Name:
- 2-HYDROXY-5-BENZYLOXYACETOPHENONE
- Synonyms
- Odatero Impurity 4;2-HYDROXY-5-BENZYLOXYACETOPHENONE;5'-Benzyloxy-2'-hydroxyacetophenone;1-[2-Hydroxy-5-(phenylMethoxy)phenyl]ethanone;Ethanone, 1-[2-hydroxy-5-(phenylMethoxy)phenyl]-;1-(2-Hydroxy-5-phenylmethoxyphenyl)ethanone - [H92760];JR-13548, 1-(5-(Benzyloxy)-2-hydroxyphenyl)ethanone, 95%
- CBNumber:
- CB7649114
- Molecular Formula:
- C15H14O3
- Molecular Weight:
- 242.27
- MDL Number:
- MFCD00598842
- MOL File:
- 30992-63-3.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H319 |
| Precautionary statements | P280-P305+P351+P338 |
| HS Code | 2914390090 |
2-HYDROXY-5-BENZYLOXYACETOPHENONE price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | H829870 | 2-Hydroxy-5-benzyloxyacetophenone | 30992-63-3 | 1g | $105 | 2021-12-16 | Buy |
| TRC | H829870 | 2-Hydroxy-5-benzyloxyacetophenone | 30992-63-3 | 2g | $185 | 2021-12-16 | Buy |
| Usbiological | 279344 | 2-Hydroxy-5-benzyloxyacetophenone | 30992-63-3 | 500mg | $410 | 2021-12-16 | Buy |
| TRC | H829870 | 2-Hydroxy-5-benzyloxyacetophenone | 30992-63-3 | 10g | $755 | 2021-12-16 | Buy |
| SynQuest Laboratories | 2620-1-63 | 1-(5-(Benzyloxy)-2-hydroxyphenyl)ethanone 95.0% | 30992-63-3 | 1g | $168 | 2021-12-16 | Buy |
2-HYDROXY-5-BENZYLOXYACETOPHENONE Chemical Properties,Uses,Production
Chemical Properties
Yellow Solid
Uses
2-Hydroxy-5-benzyloxyacetophenone (cas# 30992-63-3) is a compound useful in organic synthesis.
Preparation
Preparation by reaction of benzyl chloride with quinacetophenone in refluxing acetone in the presence of potassium carbonate,
with potassium iodide (85%) ;
without potassium iodide (31%).
Synthesis
100-39-0
490-78-8
30992-63-3
The second alternative method first employs benzyl groups to protect the hydroxyl functional group in 2,5-dihydroxyacetophenone, followed by an O-alkylation reaction under the same conditions to give acetophenone derivatives (1-6) in high yields (95%). Next, the acetophenone derivatives (1-6) were converted by the Vilsmeier-Haack reaction under standard conditions (70% yield) to the products (1-7) which were previously synthesized by other methods. Finally, the product (1-7) was subjected to Knoevenagel condensation reaction with diethyl malonate to give the target diester (1-8) in high yield (94%). Based on the analysis of the results of Scheme 2, it can be observed that both methods can be used for the synthesis of intermediates (1-7) from 2,5-dihydroxyacetophenone (1-4) in overall yields of 42% and 66%, respectively. However, the second method showed superior performance in terms of yield.
References
[1] Patent: WO2018/156459, 2018, A1. Location in patent: Page/Page column 22; 23
[2] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 1, p. 249 - 266
[3] Patent: US2007/88160, 2007, A1. Location in patent: Page/Page column 10-11
[4] Patent: US2010/22770, 2010, A1. Location in patent: Page/Page column 5-6
[5] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 4, p. 1410 - 1414
2-HYDROXY-5-BENZYLOXYACETOPHENONE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +86-15064153060 | sales01@jndxj.com | China | 297 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 4000 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14360 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8647 | 58 |
| Changzhou Helios Biomedical Science and Technology Co.,LTD. | +8618961213068 | gaoxue@czhelios.com | China | 512 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 19957148339; | market18@leapchem.com | China | 24727 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
View Lastest Price from 2-HYDROXY-5-BENZYLOXYACETOPHENONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-07-25 | 2-HYDROXY-5-BENZYLOXYACETOPHENONE
30992-63-3
|
US $0.00 / kg | 1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | |
 |
2025-06-20 | 2-HYDROXY-5-BENZYLOXYACETOPHENONE
30992-63-3
|
US $200.00-100.00 / kg | 1kg | 98% | 20tons | Anhui Dexinjia Biopharm Co., Ltd | |
 |
2024-07-29 | 2-HYDROXY-5-BENZYLOXYACETOPHENONE
30992-63-3
|
US $1.00 / KG | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- 2-HYDROXY-5-BENZYLOXYACETOPHENONE
30992-63-3
- US $0.00 / kg
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2-HYDROXY-5-BENZYLOXYACETOPHENONE
30992-63-3
- US $200.00-100.00 / kg
- 98%
- Anhui Dexinjia Biopharm Co., Ltd
-
- 2-HYDROXY-5-BENZYLOXYACETOPHENONE
30992-63-3
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
