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tert-Butyl 3-aminopyrrolidine-1-carboxylate

tert-Butyl 3-aminopyrrolidine-1-carboxylate structure

CAS No.: 186550-13-0

Chemical Name:: tert-Butyl 3-aminopyrrolidine-1-carboxylate

Synonyms: 1-BOC-3-AMINOPYRROLIDINE;CAS:186550-13-0;Methyl N-benzyl-3-;1-Boc-3-aminopyrro;3-AMINO-1-BOC-PYRROLIDINE;3-AMINO-1-N-BOC-PYRROLIDINE;1-N-BOC-3-AMINO-PYRROLIDINE;1-Boc-3-aminopyrrolidine 95%;1-Boc-3-aminopyrrolidine ,97%;DL-3-AMINO-1-N-BOC-PYRROLIDINE

CBNumber:: CB7664832

Molecular Formula:: C9H18N2O2

Molecular Weight:: 186.25

MDL Number:: MFCD01861220

MOL File:: 186550-13-0.mol

MSDS File:: SDS

Last updated:2026-01-13 11:25:47

Product description	Number	Pack Size	Price
1-Boc-3-aminopyrrolidine 95%	706582	1g	$59
3-Amino-1-(tert-butoxycarbonyl)pyrrolidine >98.0%(GC)(T)	B3890	1g	$86
3-Amino-1-(tert-butoxycarbonyl)pyrrolidine >98.0%(GC)(T)	B3890	5g	$342
Tert-butyl3-Aminopyrrolidine-1-carboxylate	T204658	1g	$75
1-Boc-3-aminopyrrolidine	263596	1g	$319
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tert-Butyl 3-aminopyrrolidine-1-carboxylate Properties

Boiling point	257.4±33.0 °C(Predicted)
Density	1.022
Flash point	91°C
refractive index	1.4710
storage temp.	2-8°C
pka	9.55±0.20(Predicted)
form	powder to lump to clear liquid
color	White or Colorless to Light yellow
Sensitive	Air Sensitive
InChI	1S/C9H18N2O2/c1-9(2,3)13-8(12)11-5-4-7(10)6-11/h7H,4-6,10H2,1-3H3
InChIKey	CMIBWIAICVBURI-UHFFFAOYSA-N
SMILES	CC(C)(C)OC(=O)N1CCC(N)C1
CAS DataBase Reference	186550-13-0(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS06

Signal word

Danger

Hazard statements

H301-H318

Precautionary statements

P280-P301+P310+P330-P305+P351+P338+P310

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

C,Xi,Xn

Risk Statements

36/37/38-44-41-22

Safety Statements

26-36/37/39

RIDADR

2810

WGK Germany

Hazard Note

Irritant

HazardClass

PackingGroup

Ⅲ

HS Code

29339900

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Eye Dam. 1

Limited Quantities

5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	1
3		0

tert-Butyl 3-aminopyrrolidine-1-carboxylate price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	706582	1-Boc-3-aminopyrrolidine 95%	186550-13-0	1g	$59	2026-03-19	Buy
TCI Chemical	B3890	3-Amino-1-(tert-butoxycarbonyl)pyrrolidine >98.0%(GC)(T)	186550-13-0	1g	$86	2026-03-19	Buy
TCI Chemical	B3890	3-Amino-1-(tert-butoxycarbonyl)pyrrolidine >98.0%(GC)(T)	186550-13-0	5g	$342	2026-03-19	Buy
TRC	T204658	Tert-butyl3-Aminopyrrolidine-1-carboxylate	186550-13-0	1g	$75	2021-12-16	Buy
Usbiological	263596	1-Boc-3-aminopyrrolidine	186550-13-0	1g	$319	2021-12-16	Buy

Product number	Packaging	Price	Buy
706582	1g	$59	Buy
B3890	1g	$86	Buy
B3890	5g	$342	Buy
T204658	1g	$75	Buy
263596	1g	$319	Buy

tert-Butyl 3-aminopyrrolidine-1-carboxylate Chemical Properties,Uses,Production

Chemical Properties

Colorless low melting solid or liquid

Uses

1-Boc-3-Aminopyrrolidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis

tert-butyl 3-(benzylamino)pyrrolidine-1-carboxylate

862906-31-8

186550-13-0

Step (ii): preparation of tert-butyl 3-aminopyrrolidine-1-carboxylate (Formula 49) To a stirred solution of tert-butyl 3-hydroxypyrrolidine-1-carboxylate (Formula 48, 1.15 g, 4.16 mmol) in methanol (16.6 mL) was added 10% palladium/carbon catalyst (345 mg). The reaction mixture was stirred for 16 hours under a hydrogen atmosphere (hydrogen pressure applied via a double-layer balloon). Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad to remove the catalyst and the filtrate was concentrated under reduced pressure. The crude product was purified by silica gel fast column chromatography to afford the target compound tert-butyl 3-aminopyrrolidine-1-carboxylate (Formula 49, 640 mg) in 82% yield. 1H-NMR (CDCl3): δ 3.65-3.45 (m, 3H), 3.45-3.33 (m, 1H), 3.20-3.0 (m, 1H), 2.12-2.02 (m, 1H), 1.80-1.65 (m, 1H), 1.46 (s, 9H). Mass spectrum (m/z): 187 [M+H]+.

References

[1] Patent: WO2005/77924, 2005, A1. Location in patent: Page/Page column 76
[2] Patent: WO2011/30349, 2011, A1. Location in patent: Page/Page column 36-37

tert-Butyl 3-aminopyrrolidine-1-carboxylate synthesis

Synthesis of tert-Butyl 3-aminopyrrolidine-1-carboxylate from Di-tert-butyl dicarbonate and 3-Aminopyrrolidine

tert-Butyl 3-aminopyrrolidine-1-carboxylate Preparation Products And Raw materials

Raw materials

3-Aminopyrrolidine dihydrochloride Ethanol Di-tert-butyl dicarbonate Sodium Triethylamine

Tosyl chloride Tetrahydrofuran 1-(tert-Butoxycarbonyl)-3-pyrrolidinol Dichloromethane Methanol

Sodium hydroxide Isopropyl alcohol 1-Butanol Ammonia tert-butyl 3-(benzylamino)pyrrolidine-1-carboxylate

Methyl 1-Boc-3-pyrrolidinecarboxylate N-Boc-3-azido-pyrrolidine 1-BOC-3-METHANESULFONYLOXYPYRROLIDINE

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Preparation Products

tert-Butyl 3-aminopyrrolidine-1-carboxylate Suppliers

Global( 251)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13815	58
Chembon Pharmaceutical Co., Ltd.	+86-28-8425-2981		CHINA	722	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29823	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2176	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Chembon Pharmaceutical Co., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Accela ChemBio Inc.	58
Changzhou Ditong Chemical Co.,Ltd	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from tert-Butyl 3-aminopyrrolidine-1-carboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-04-14	1-Boc-3-aminopyrrolidine 186550-13-0	US $0.00 / KG	1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
	2019-07-06	tert-Butyl 3-aminopyrrolidine-1-carboxylate 186550-13-0	US $1.00 / KG	1KG	98%	500kg	Career Henan Chemical Co

1-Boc-3-aminopyrrolidine
186550-13-0
US $0.00 / KG
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

tert-Butyl 3-aminopyrrolidine-1-carboxylate
186550-13-0
US $1.00 / KG
98%
Career Henan Chemical Co

tert-Butyl 3-aminopyrrolidine-1-carboxylate Spectrum

tert-Butyl 3-aminopyrrolidine-1-carboxylate(186550-13-0)¹HNMR

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TERT-BUTYL 3-AMINOPYRROLIDINE-1-CARBOXYLATE 1-BOC-3-AMINOPYRROLIDINE 1-N-BOC-3-AMINO-PYRROLIDINE (+/-)-3-AMINO-1-BOC-PYRROLIDINE 3-AMINO-1-BOC-PYRROLIDINE 3-AMINO-1-N-BOC-PYRROLIDINE 3-AMINOPYRROLIDINE, N1-BOC PROTECTED 3-AMINO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-TERT-BUTOXYCARBONYL-3-AMINOPYRROLIDINE 1-Boc-3-aminopyrrolidine 95% 3-Aminopyrrolidine,N1-BOCprotected97% DL-3-AMINO-1-N-BOC-PYRROLIDINE (-3-Amino-1-Boc-pyrrolidine HCl 3-Amino-1-(tert-butoxycarbonyl)pyrrolidine Methyl N-benzyl-3- tert-butyl 3-aminopyrrolidine-1-carboxylate(SALTDATA: FREE) DL-3-Amino-1-N-Boc-Pyrrolidine 1-N-Boc-3-Aminopyrrolidine 1-Boc-3-aminopyrrolidine ,97% (+/-)-3-AMINO-1-N-BOC-PYRROLIDINE-cictric acid salt tert-Butyl 3-aminopyrrolidine-1-carboxylate, 3-Amino-1-(tert-butoxycarbonyl)pyrrolidine (+/-)-3-AMINO-1-N-BOC-PYRROLIDINE-citrate 1-Boc-3-aminopyrrolidine 1-(tert-Butoxyarbonyl)-3-aminopyrrolidine 3-Amino-1-Boc-pyrrolidine 3-aMino-1-pyrrolidinecarboxylic acid,1,1-diMethylethyl ester 1-Pyrrolidinecarboxylic acid, 3-amino-, 1,1-dimethylethyl ester (^+)-1-Boc-3-aminopyrrolidine,96% 3-amino-1-(t-butoxycarbonyl)pyrrolidine 1-Boc-3-aminopyrro 1-Boc-3-tert-Butyl3-aminopyrrolidine-1-carboxylate 3-Amino-1-(tert-butoxycarbonyl)pyrrolidine > 1-(tert-Butoxyarbonyl)-3-aminopyrrolidine (+/-)-3-Amino-1-N-Boc-pyrrolidine 1,1-Dimethylethyl 3-amino-1-pyrrolidinecarboxylate tert-Butyl3-aminipyrrolidine-1-carboxylate CAS:186550-13-0 186550-13-0 pharmacetical Amines Pyrrolidines Pyrrole&Pyrrolidine&Pyrroline