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Antide

Antide structure

CAS No.: 112568-12-4

Chemical Name:: Antide

Synonyms: Antide Acetate;lyl-;ANTIDE;iturelix;Orf 23541;Brn 4866881;Antide impurity;ANTIDE (iturelix);Iturelix, ORF 23541;Antide >=97% (HPLC)

CBNumber:: CB7665086

Molecular Formula:: C82H108ClN17O14

Molecular Weight:: 1591.29

MDL Number:: MFCD00133104

MOL File:: 112568-12-4.mol

Last updated:2026-01-21 16:49:52

Product description	Number	Pack Size	Price
Antide ≥97% (HPLC)	A8802	1mg	$198
Antide	A2298-09T	1mg	$368
Antide Acetate	169600	1mg	$549
Antide	A637190	1mg	$140
Antide	A637190	10mg	$910
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Antide Properties

Boiling point	1798.0±65.0 °C(Predicted)
Density	1.258±0.06 g/cm3(Predicted)
storage temp.	−20°C
pka	12.78±0.46(Predicted)
form	Solid
color	White to off-white
InChIKey	QRYFGTULTGLGHU-NBERXCRTSA-N
FDA UNII	94055UOQ3Y

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H360
Precautionary statements	P201-P308+P313-P202-P280-P405-P501a
Hazard Codes	T
Risk Statements	60
Safety Statements	53-22-36/37/39-45
WGK Germany	3
RTECS	AY2961700
HS Code	3504009000

Antide price More Price(15)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A8802	Antide ≥97% (HPLC)	112568-12-4	1mg	$198	2022-05-15	Buy
Usbiological	A2298-09T	Antide	112568-12-4	1mg	$368	2021-12-16	Buy
Usbiological	169600	Antide Acetate	112568-12-4	1mg	$549	2021-12-16	Buy
TRC	A637190	Antide	112568-12-4	1mg	$140	2021-12-16	Buy
TRC	A637190	Antide	112568-12-4	10mg	$910	2021-12-16	Buy

Product number	Packaging	Price	Buy
A8802	1mg	$198	Buy
A2298-09T	1mg	$368	Buy
169600	1mg	$549	Buy
A637190	1mg	$140	Buy
A637190	10mg	$910	Buy

Antide Chemical Properties,Uses,Production

Uses

Reversible inhibition of gonadotropin secretion and subsequent suppression of ovarian and testicular steroid secretio (gonadotropin releasing hormone antagonist).

Uses

Antide, is a GnRH and LH-RH antagonist, and with high anti-ovulatory and negligible histamine release activity.

Synthesis

Antide acetate was prepared as follows: the peptide intermediate was first treated with a suitable thiol to remove the Nps protecting group. It was then reacted with 2-benzyl-4-carboxypyridine in DMF in DCC as a coupling agent to acylate the Orn residue at the 5-position. After washing, the peptide resin was treated with piperidine to remove the Fmoc protecting group, followed by treatment with nicotinic acid and DIIC to acylate the D-Lys residue at the 6-position. Following cleavage and HPLC purification, the GnRH antagonist was tested and the peptide was considered effective in preventing ovulation in low-dose female mammals.

in vivo

Antide (subcutaneously; 1, 3, 6, 10 and 15 mg/kg; once or on 5 consecutive days) can induce a long-term chemical castration in adult male rats and cynomolgus monkeys^[1].

Animal Model:	Cynomolgus monkey and rat^[1]
Dosage:	1, 3, 6, 10 and 15 mg/kg
Administration:	Subcutaneous, once or on 5 consecutive days
Result:	Had a dose-dependent inhibitory effect on serum concentration of LH (only rat) and testosterone and on the weights of the testes, prostates and seminal vesicles. Achieved long-lasting castration-like effects at concentrations between 6 (less than or equal to 8 weeks) and 15 mg/kg (greater than 8 weeks) in the rat. Induced a prolonged inhibitory effect only at 15 mg/kg and the duration was only 2-3 weeks in the cynomolgus monkey.

Description

Antide acetate (Ac-AA10-NH₂) is an LHRH antagonist and represses LH and FSH release from the pituitary gland. Antide Mw is 1590.6 Dalton.

Antide Preparation Products And Raw materials

Raw materials

BOC-D-4-Chlorophe (R)-N-Boc-(3-Pyridyl)alanine Boc-3-(2-Naphthyl)-D-alanine

Preparation Products

Antide Suppliers

Global( 195)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	8496	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	615	58
Adachibio Inc.	+81-8027837258; +8108027837258	sales@adachibio.com	Japan	992	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21595	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29830	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	995	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8830	58

Supplier	Advantage
Zibo Hangyu Biotechnology Development Co., Ltd	58
Nantong Guangyuan Chemicl Co,Ltd	58
Adachibio Inc.	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
BOC Sciences	58
Cellmano Biotech Limited	58
CONIER CHEM AND PHARMA LIMITED	58
Neostar United (Changzhou) Industrial Co., Ltd.	58

View Lastest Price from Antide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-21	Antide acetate	US $196.00-592.00 / mg		99.57%	10g	TargetMol Chemicals Inc.
2025-06-03	Antide 112568-12-4	US $70.00-700.00 / kg	10kg	0.99	20tons	Zibo Hangyu Biotechnology Development Co., Ltd
2025-04-04	Antide 112568-12-4	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

Antide acetate
US $196.00-592.00 / mg
99.57%
TargetMol Chemicals Inc.

Antide
112568-12-4
US $70.00-700.00 / kg
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

Antide
112568-12-4
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

112568-12-4(Antide)Related Search:

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H-ALA-ALA-ALA-NH2 HCL 3-NAPHTHALEN-2-YL-PROPIONALDEHYDE H-GLY-LEU-NH2 HCL H-D-PHE-NH2 HCL AC-LYS-NH2 HCL

1-METHYL-2-PYRIDIN-4-YL-ETHYLAMINE (R)-(-)-2-AMINOBUTANAMIDE HYDROCHLORIDE, 97% 1-(N-ACETYLAMINO)-2-(4-CHLOROPHENYL)-ETHANE H-NLE-NH2 HCL 2-AMINO-1-PYRROLIDIN-1-YL-ETHANONE HCL

p-Chloroamphetamine DL-NORLEUCINE AMIDE HYDROCHLORIDE H-PRO-GLY-NH2 HCL

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iturelix Ac-D-2-Nal-4-chloro-D-Phe-beta-(3-pyridyl)-D-Ala-Ser-Lys(nicotinoyl)-D-Lys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-D-Ala-NH2 AC-DNAL-D: P-CLPHE-DPAL-SER-LYS: NICOTINOYL-DLYS: NICOTINOYL-LEU-LYS: ISOPROPYL-PRO-DALA-NH2 Brn 4866881 D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N(sup 6)-(3-pyridinylcarbonyl)-L-lysyl-N(sup 6)-(3-pyridinylcarbonyl)-D-lysyl-L-leucyl-N(sup 6)-(1-methylethyl)-L-lysyl-L-prolyl- D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N6-(3-pyridinylcarbonyl)-L-lysyl-N6-(3-pyridinylcarbonyl)-D-lysyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl- Orf 23541 Ac-D-2-Nal-4-chloro-D-Phe-b-(3-pyridyl)-D-Ala-Ser-Lys(nicotinoyl)-D-Lys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-D-Ala-NH2 Iturelix, ORF 23541 Ac-D-2-Nal-p-chloro-D-Phe-(3-pyridyl)-D-Ala-Ser-Lys(nicotinoyl) -D-Lys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-D-Ala-NH2 ANTIDE (iturelix) Antide, Iturelix, ORF 23541 Antide Acetate, Iturelix -(3-pyridinylcarbonyl)-d-lysyl-l-leucyl-n(sup6)-(1-methylethyl)-l-lysyl-l-pro 3-pyridinyl)-d-alanyl-l-seryl-n(sup6)-(3-pyridinylcarbonyl)-l-lysyl-n(sup6) lyl- ANTIDE AC-(D-NAL)-(D-P-CL-PHE)-(D-PAL)-SER-LYS(NICOTINOYL)-[D-LYS(NICOTINOYL)]-LEU-LYS(ISOPROPYL)-PRO-[D-ALA]-NH2 AC-D-ALA(2-NAPHTHYL)-D-PHE(4-CL)-D-ALA(3'-PYRIDYL)-SER-LYS(NICOTINOYL)-D-LYS(NICOTINOYL)-LEU-LYS(ISOPROPYL)-PRO-D-ALA-NH2 AC-D-2-NAL-P-CHLORO-D-PHE-BETA-(3-PYRIDYL)-D-ALA-SER-LYS(NICOTINOYL)-D-LYS(NICOTINOYL)-LEU-LYS(ISOPROPYL)-PRO-D-ALA-NH2 Antide Acetate Ac-D-2-Nal-p-chloro-D-Phe-.beta.-(3-pyridyl)-D-Ala-Ser-Lys(nicotinoyl)-D-Lys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-D-Ala-NH2 Antide >=97% (HPLC) Antide impurity Peptides Antide Acetate N-((4R,7R,10R,13S,16S,19R)-19-(((S)-1-(((S)-1-((S)-2-(((R)-1-amino-1-oxopropan-2-yl)carbamoyl)pyrrolidin-1-yl)-6-(isopropylamino)-1-oxohexan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-7-(4-chlorobenzyl)-13-(hydroxymethyl)-4-(naphthalen-2-ylmethyl)-16-(4-(nicotinamido)butyl)-2,5,8,11,14,17-hexaoxo-10-(pyridin-3-ylmethyl)-3,6,9,12,15,18-hexaazatricosan-23-yl)nicotinamide N-((4R,7R,10R,13S,16S,19R)-19-(((S)-1-(((S)-1-((S)-2-(((R)-1-Amino-1-oxo-propan-2-yl)-carbamoyl)-pyrrolidin-1-yl)-6-(isopropylamino)-1-oxohexan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-carbamoyl)-7-(4-chlorobenzyl)-13-(hydroxymethyl)-4-(naphthalen-2-ylmethyl)-16-(4-(nicotincarboxcarboxcarboxamido)butyl)-2,5,8,11,14,17-hexaoxo-10-(pyridin-3-ylmethyl)-3,6,9,12,15,18-hexaazatricosan-23-yl)-pyridin-3-carboxamide 112568-12-4 C82H108ClN17O14 LH-RH Peptides Releasing Factors Biochemicals and Reagents Amino Acids and Peptides BioChemical hormones Peptide LH-RH LH-RHPeptides for Cell Biology Neuropeptides Releasing Factors