CYP1A1
- CAS No.
- Chemical Name:
- CYP1A1
- Synonyms
- CP12;CYP1A1;P450-3;CYP1A1 YR (HUMAN);CYP1A1 MICROSOMES HUMAN;Cytochrome P450 human;Mouse Anti-CYP1A1 antibody;CYTOCHROME P450 1A1 (HUMAN);Anti-Cyp1a2 antibody produced in goat;CYTOCHROME P450 ISOZYME MICROSOMES HUMAN
- CBNumber:
- CB7670943
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD03456520
- MOL File:
- Mol file
| storage temp. | −70°C |
|---|---|
| form | buffered aqueous solution |
| biological source | human |
| Water Solubility | water: soluble |
| Specific Activity | ≥4units/pmol enzyme |
| Major Application | cell analysis |
| FDA UNII | SM5MFZ7FKP |
| UNSPSC Code | 12352204 |
| NACRES | NA.61 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
|---|---|
| Safety Statements | 23-24/25 |
| WGK Germany | 1 |
| Storage Class | 10 - Combustible liquids |
CYP1A1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C5614 | Cytochrome P450 human 1A2 Isozyme Microsomes, with P450 Reductase and cytochrome b5, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4) | 1vial | $618 | 2026-04-30 | Buy | |
| Sigma-Aldrich | C5235 | Cytochrome P450 human 4F3B isozyme microsomes, with P450 Reductase and cytochrome b5, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4) | 1vial | $430 | 2026-04-30 | Buy | |
| Sigma-Aldrich | C4982 | Cytochrome P450 human 3A4 isozyme microsomes, with P450 reductase and cytochrome b5, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4) | 1VIAL | $604 | 2026-04-30 | Buy | |
| Sigma-Aldrich | C3735 | Cytochrome P450 human 1A1 Isozyme Microsomes, with P450 Reductase, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4) | 1 vial | $500 | 2026-04-30 | Buy | |
| Usbiological | 559838 | CYP1A1 PurifiedbyProteinGaffinitychromatography. | 50ug | $509 | 2026-06-03 | Buy |
CYP1A1 Chemical Properties, Uses, Production
Description
The CYP1A1 (also called aromatic hydrocarbon hydroxylase) is expressed primarily in extrahepatic tissues, small intestine, placenta, skin, and lung as well as in the liver in response to the presence of CYP1A1 inducers, such as PAHs (i.e., in cigarette smoke and the carcinogen 3-methylcholanthrene), α-naphthoflavone (a noncarcinogenic inducer related to dietary flavones), and indole-3-carbinol (found in Brussel sprouts and related vegetables). The CYP1A1 metabolizes a range of PAHs, including a large number of procarcinogens and promutagens. Diethylstilbestrol and 2- and 4-hydroxyestradiol (catecholestrogens) are oxidized by CYP1A1 to their quinone analogues, which normally are reduced to inactive metabolites. In the absence of a detoxifying reduction step, however, the quinones may accumulate and initiate carcinogenic processes or cell death by covalently damaging DNA or cellular proteins. Interindividual variation in the inducible expression of CYP1A1 might be related to a genetic difference in aromatic hormone (Ah) receptor expression, which could explain differences in individual susceptibility to cigarette smoke–induced lung cancer.
Biochem/physiol Actions
Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Some isoforms have narrow substrate specificity, while others are promiscuous.
Mechanism of action
The mechanism for the induction of the CYP1A1 gene begins with binding of the inducing agents to a cytosolic receptor protein, the Ah receptor, which is translocated to the nucleus and binds to the DNA of the CYP1A1 gene, thus enhancing its rate of transcription. The presence of the Ah receptor in hepatic and intestinal tissues may have implications beyond xenobiotic metabolism and may play a role in the induction of other genes for the control of cellular growth and differentiation. On the other hand, CYP1A1 may metabolize procarcinogens to hydroxylated inactive compounds that are not mutagenic. The question of how the bowel protects itself from ingested compounds known to be activated by CYP1A1 (i.e., PAH) remains unanswered.
CYP1A1 Preparation Products And Raw materials
Raw materials
Preparation Products
CYP1A1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Huzhen Industrial Co., LTD | 021-60345367 13916550749 | sales@shzbio.com | China | 9965 | 58 |
| Aopeisai Biotechnology (Shanghai) Co., Ltd | 13061929770 | 3004391297@qq.com | China | 1780 | 58 |
| Shanghai Yubo Biotechnology Co., Ltd | 021-60514606 18321282235 | sale1@shybsw.net | China | 8165 | 58 |
| shlmai | 021-67680335 13052188602 | sale1@shlmai.net | China | 10000 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Huzhen Industrial Co., LTD | 58 |
| Aopeisai Biotechnology (Shanghai) Co., Ltd | 58 |
| Shanghai Yubo Biotechnology Co., Ltd | 58 |
| shlmai | 58 |
