3-Cyano-6-methyl-2(1H)-pyridinone
- CAS No.
- 4241-27-4
- Chemical Name:
- 3-Cyano-6-methyl-2(1H)-pyridinone
- Synonyms
- NSC 15124;3-CYANO-6-METHYL-2-PYRIDONE;6-METHYL-3-CYANO-2-PYRIDONE;6-Methyl-3-cyanopyridin-2ol;5-cyano-6-hydroxy-2-picoline;3-Cyano-6-methyl-2-pyridinol;3-Cyano-6-methyl-2-pyridone,98%;3-cyano-6-methyl-2(1h)-pyridone;3-Cyano-6-methyl-2-pyridone >3-cyano-6-methyl-2(H)pyridinone
- CBNumber:
- CB7672912
- Molecular Formula:
- C7H6N2O
- Molecular Weight:
- 134.14
- MDL Number:
- MFCD00006013
- MOL File:
- 4241-27-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Cyano-6-methyl-2(1H)-pyridinone 97% | 278246 | 5g | $89.1 |
| 3-Cyano-6-methyl-2-pyridone >98.0%(T) | C2210 | 5g | $56 |
| 3-Cyano-6-methyl-2-pyridone >98.0%(T) | C2210 | 25g | $173 |
| 3-Cyano-6-methyl-2(1H)-pyridinone | C981880 | 10g | $100 |
| 3-Cyano-6-methyl-2-(1H)-pyridinone | FC34784 | 25g | $150 |
| More product size | |||
| Melting point | 293-295 °C (lit.) |
|---|---|
| Boiling point | 247.23°C (rough estimate) |
| Density | 1.2296 (rough estimate) |
| refractive index | 1.5880 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 9.03±0.10(Predicted) |
| form | Solid |
| color | White to Pale Yellow |
| Water Solubility | 2.38 g/L (20 ºC) |
| BRN | 120412 |
| InChI | InChI=1S/C7H6N2O/c1-5-2-3-6(4-8)7(10)9-5/h2-3H,1H3,(H,9,10) |
| InChIKey | FIMGYEKEYXUTGD-UHFFFAOYSA-N |
| SMILES | C1(=O)NC(C)=CC=C1C#N |
| CAS DataBase Reference | 4241-27-4(CAS DataBase Reference) |
| EPA Substance Registry System | 3-Pyridinecarbonitrile, 1,2-dihydro-6-methyl-2-oxo- (4241-27-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H301-H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P280a-P301+P310a-P501a-P261-P280-P305+P351+P338-P264-P270-P301+P310+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P405-P501 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 36/37/39-26-22-36 | |||||||||
| RIDADR | 3276 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
3-Cyano-6-methyl-2(1H)-pyridinone price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 278246 | 3-Cyano-6-methyl-2(1H)-pyridinone 97% | 4241-27-4 | 5g | $89.1 | 2023-01-07 | Buy |
| TCI Chemical | C2210 | 3-Cyano-6-methyl-2-pyridone >98.0%(T) | 4241-27-4 | 5g | $56 | 2025-07-31 | Buy |
| TCI Chemical | C2210 | 3-Cyano-6-methyl-2-pyridone >98.0%(T) | 4241-27-4 | 25g | $173 | 2025-07-31 | Buy |
| TRC | C981880 | 3-Cyano-6-methyl-2(1H)-pyridinone | 4241-27-4 | 10g | $100 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC34784 | 3-Cyano-6-methyl-2-(1H)-pyridinone | 4241-27-4 | 25g | $150 | 2021-12-16 | Buy |
3-Cyano-6-methyl-2(1H)-pyridinone Chemical Properties,Uses,Production
Chemical Properties
SLIGHTLY YELLOW GRANULAR CRYSTALLINE POWDER
Uses
3-Cyano-6-methyl-2(1H)-pyridinone is a reactant used in the synthesis of Milrinone (M344680), a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. 3-It has also been used in the preparation of the N3?-pyridyl thiamine, a potent in vitro thiamine antagonist.
General Description
Supramolecular structures of coordination copper(I) compounds of 3-cyano-6-methyl-2(1H)-pyridinone has been investigated.
Synthesis
67-64-1
107-91-5
109-94-4
4241-27-4
A 950 ml solution of tetrahydrofuran (THF) with 46.5 g of sodium methanolate was added to the reaction vessel and cooled in an ice bath to an internal temperature of 0 to 5°C. Subsequently, a mixed solution of 46.5 g of acetone and 59.6 g of ethyl formate was slowly added with a controlled drip time of 1 hour. After the dropwise addition, the ice bath was removed and the reaction system was allowed to slowly warm up to room temperature within 1 hour. Afterwards, the reaction solution was concentrated under reduced pressure (temperature not exceeding 50°C). The concentrate was transferred to another reaction vessel, 400 ml of aqueous solution of 67 g of cyanoacetamide and an appropriate amount of piperidine acetic acid (as a condensation catalyst) were added, and the reaction was refluxed for 2 hours. Upon completion of the reaction, the reaction was cooled to room temperature and the pH was adjusted with acetic acid to about 5. The reaction mixture was allowed to stand at room temperature overnight and subsequently cooled in an ice bath for 45 minutes for filtration. The filter cake was washed three times with ice water and finally dried under vacuum at 80 °C overnight to afford 65.5 g of the target compound 3-cyano-6-methyl-pyridone (61.0% yield) as a yellow solid.
References
[1] Patent: CN105037261, 2017, B. Location in patent: Paragraph 0048-0049
[2] Molecules, 2018, vol. 23, # 7,
[3] Patent: US6342504, 2002, B1. Location in patent: Page column 50
[4] Journal of Medicinal Chemistry, 1994, vol. 37, # 20, p. 3303 - 3312
[5] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 6, p. 2212 - 2215
3-Cyano-6-methyl-2(1H)-pyridinone Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3589 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
View Lastest Price from 3-Cyano-6-methyl-2(1H)-pyridinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-12 | 3-Cyano-6-Methyl-2-Pyridone
4241-27-4
|
US $1.00-2.00 / KG | 1KG | 99% | 100000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-12-01 | 3-Cyano-6-methyl-2(1H)-pyridinone
4241-27-4
|
US $0.00 / kg | 1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2021-07-02 | 3-Cyano-6-Methyl-quinolin-2(1H)-one
4241-27-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 3-Cyano-6-Methyl-2-Pyridone
4241-27-4
- US $1.00-2.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 3-Cyano-6-methyl-2(1H)-pyridinone
4241-27-4
- US $0.00 / kg
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 3-Cyano-6-Methyl-quinolin-2(1H)-one
4241-27-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
