7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-HYDROXY-4-(4-IODOPHENOXY)-1-BUTENYL]-7-OXABICYCLO[2.2.1]HEPT-2-YL]-5Z-HEPTENOIC ACID
- CAS No.
- 128719-90-4
- Chemical Name:
- 7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-HYDROXY-4-(4-IODOPHENOXY)-1-BUTENYL]-7-OXABICYCLO[2.2.1]HEPT-2-YL]-5Z-HEPTENOIC ACID
- Synonyms
- I-BOP;I-BOP >=95% (HPLC);UYFMSCHBODMWON-JCPFAPSOSA-N;7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-HYDROXY-4-(4-IODOPHENOXY)-1-BUTENYL]-7-OXABICYCLO[2.2.1]HEPT-2-YL]-5Z-HEPTENOIC ACID;(5Z)-7-[(1S,4R)-3β-[(1E,3R)-3-Hydroxy-4-(p-iodophenoxy)-1-butenyl]-7-oxabicyclo[2.2.1]heptane-2α-yl]-5-heptenoic acid;(5Z)-7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-Hydroxy-4-(4-iodophenoxy)-1-buten-1-yl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid;5-Heptenoic acid, 7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-hydroxy-4-(4-iodophenoxy)-1-buten-1-yl]-7-oxabicyclo[2.2.1]hept-2-yl]-, (5Z)-
- CBNumber:
- CB7674385
- Molecular Formula:
- C23H29IO5
- Molecular Weight:
- 512.38
- MDL Number:
- MFCD00084824
- MOL File:
- 128719-90-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| I-BOP ≥95% (HPLC) | SML0504 | 1mg | $541 |
| I-BOP ≥95% (HPLC) | SML0504 | 5mg | $2180 |
| I-BOP ≥95% | 19600 | 100μg | $84 |
| I-BOP ≥95% | 19600 | 500μg | $369 |
| I-BOP ≥95% | 19600 | 1mg | $602 |
7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-HYDROXY-4-(4-IODOPHENOXY)-1-BUTENYL]-7-OXABICYCLO[2.2.1]HEPT-2-YL]-5Z-HEPTENOIC ACID Properties
| Boiling point | 634.5±55.0 °C(Predicted) |
|---|---|
| Density | 1.483±0.06 g/cm3(Predicted) |
| Flash point | 14℃ |
| storage temp. | -20°C |
| solubility | DMF: >50 mg/ml (from Pinane TXA2); DMSO: >25 mg/ml (from Pinane TXA2); Ethanol: >100 mg/ml (from Pinane TXA2); PBS (pH 7.2): 3 mg/ml |
| pka | 4.76±0.10(Predicted) |
| form | solution |
| color | colorless to faint yellow |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) | ![]() ![]() GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P305+P351+P338 | |||||||||
| Hazard Codes | F | |||||||||
| Risk Statements | 11 | |||||||||
| Safety Statements | 7-16 | |||||||||
| RIDADR | UN1170 - class 3 - PG 2 - Ethanol, solution | |||||||||
| WGK Germany | 2 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Flam. Liq. 2 |
|||||||||
| NFPA 704 |
|
7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-HYDROXY-4-(4-IODOPHENOXY)-1-BUTENYL]-7-OXABICYCLO[2.2.1]HEPT-2-YL]-5Z-HEPTENOIC ACID price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0504 | I-BOP ≥95% (HPLC) | 128719-90-4 | 1mg | $541 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML0504 | I-BOP ≥95% (HPLC) | 128719-90-4 | 5mg | $2180 | 2025-07-31 | Buy |
| Cayman Chemical | 19600 | I-BOP ≥95% | 128719-90-4 | 100μg | $84 | 2024-03-01 | Buy |
| Cayman Chemical | 19600 | I-BOP ≥95% | 128719-90-4 | 500μg | $369 | 2024-03-01 | Buy |
| Cayman Chemical | 19600 | I-BOP ≥95% | 128719-90-4 | 1mg | $602 | 2024-03-01 | Buy |
7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-HYDROXY-4-(4-IODOPHENOXY)-1-BUTENYL]-7-OXABICYCLO[2.2.1]HEPT-2-YL]-5Z-HEPTENOIC ACID Chemical Properties,Uses,Production
Uses
I-BOP is an agonist for thromboxane A2 receptor (TP) with a KD of 0.61 nM. I-BOP promotes proliferation through activation of PI3K pathway in vascular smooth muscle[1]. I-BOP dose-dependently biphasicly affects the excitatory postsynaptic potential (e.p.s.p.) in hippocampal neurons[2].
Biochem/physiol Actions
I-BOP is a potent thromboxane (TP) receptor agonist. I-BOP induces human platelet aggregation with an EC50 value of 0.34 nM.
References
[1] Morinelli TA, et al., Tyrosine phosphorylation of phosphatidylinositol 3-kinase and of the thromboxane A2 (TXA2) receptor by the TXA2 mimetic I-BOP in A7r5 cells. Biochem Pharmacol. 1997 Jun 15;53(12):1823-32. DOI:10.1016/s0006-2952(97)00005-1
[2] Hsu KS, et al., Thromboxane A2 agonist modulation of excitatory synaptic transmission in the rat hippocampal slice. Br J Pharmacol. 1996 Aug;118(8):2220-7. DOI:10.1111/j.1476-5381.1996.tb15666.x
7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-HYDROXY-4-(4-IODOPHENOXY)-1-BUTENYL]-7-OXABICYCLO[2.2.1]HEPT-2-YL]-5Z-HEPTENOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-HYDROXY-4-(4-IODOPHENOXY)-1-BUTENYL]-7-OXABICYCLO[2.2.1]HEPT-2-YL]-5Z-HEPTENOIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4720 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| HUNAN CHEMFISH SCIENTIFIC CO.,LTD | +86-0731-85567275 17788968862 | sales05@chemfish.com | China | 7571 | 58 |
| Xibao Biotechnology (Shanghai) Co., Ltd. | 13761246140 | 58642714@qq.com | China | 415 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44895 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25004 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24963 | 58 |







