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Bis(2-chloroethyl)amine hydrochloride

Bis(2-chloroethyl)amine hydrochloride structure

CAS No.: 821-48-7

Chemical Name:: Bis(2-chloroethyl)amine hydrochloride

Synonyms: BIS(2-CHLOROETHYL)AMMONIUM CHLORIDE;CyclophosphaMide Related CoMpound A;is(2-chloroethyl)aMine hydrochloride;2-Chloro-N-(2-chloroethyl)ethylamine hydrochloride;nc26;sk555;tl161;leo72a;Eparina;nsc10873

CBNumber:: CB7675423

Molecular Formula:: C4H10Cl3N

Molecular Weight:: 178.49

MDL Number:: MFCD00012515

MOL File:: 821-48-7.mol

Last updated:2026-01-13 11:25:23

Product description	Number	Pack Size	Price
Bis(2-chloroethyl)amine hydrochloride 98%	B38503	25g	$66.1
Bis(2-chloroethyl)amine hydrochloride 98%	B38503	100g	$81.5
Bis(2-chloroethyl)ammonium chloride for synthesis	8.20159	100g	$41.3
Bis(2-chloroethyl)amine Hydrochloride >99.0%(T)	B1210	25g	$27
Bis(2-chloroethyl)amine Hydrochloride >99.0%(T)	B1210	100g	$76
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Bis(2-chloroethyl)amine hydrochloride Properties

Melting point	212-214 °C(lit.)
storage temp.	Store below +30°C.
solubility	>100g/l
form	Crystalline Powder
color	White to beige
Water Solubility	SOLUBLE
Sensitive	Hygroscopic
BRN	3550356
InChI	InChI=1S/C4H9Cl2N.ClH/c5-1-3-7-4-2-6;/h7H,1-4H2;1H
InChIKey	YMDZDFSUDFLGMX-UHFFFAOYSA-N
SMILES	N(CCCl)CCCl.Cl
CAS DataBase Reference	821-48-7(CAS DataBase Reference)
FDA UNII	LY407360DG
NIST Chemistry Reference	2,2'-Dichlorodiethylamine hydrochloride(821-48-7)
EPA Substance Registry System	Ethanamine, 2-chloro-N-(2-chloroethyl)-, hydrochloride (821-48-7)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H290-H302-H314

Precautionary statements

P234-P260-P280-P301+P312-P303+P361+P353-P305+P351+P338

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xi,T,C

Risk Statements

36/37/38-36-34

Safety Statements

26-45-36/37/39-27

RIDADR

2811

WGK Germany

RTECS

IA1225000

Hazard Note

Irritant/Toxic

TSCA

TSCA listed

HazardClass

PackingGroup

III

HS Code

29211980

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1
Met. Corr. 1
Skin Corr. 1B

Toxicity

LD50 orally in Rabbit: 1150 mg/kg

NFPA 704

	1
3		0

Bis(2-chloroethyl)amine hydrochloride price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B38503	Bis(2-chloroethyl)amine hydrochloride 98%	821-48-7	25g	$66.1	2025-07-31	Buy
Sigma-Aldrich	B38503	Bis(2-chloroethyl)amine hydrochloride 98%	821-48-7	100g	$81.5	2025-07-31	Buy
Sigma-Aldrich	8.20159	Bis(2-chloroethyl)ammonium chloride for synthesis	821-48-7	100g	$41.3	2025-07-31	Buy
TCI Chemical	B1210	Bis(2-chloroethyl)amine Hydrochloride >99.0%(T)	821-48-7	25g	$27	2025-07-31	Buy
TCI Chemical	B1210	Bis(2-chloroethyl)amine Hydrochloride >99.0%(T)	821-48-7	100g	$76	2025-07-31	Buy

Product number	Packaging	Price	Buy
B38503	25g	$66.1	Buy
B38503	100g	$81.5	Buy
8.20159	100g	$41.3	Buy
B1210	25g	$27	Buy
B1210	100g	$76	Buy

Bis(2-chloroethyl)amine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

white to beige crystalline powder

Uses

A cytotoxic metabolite of Cyclophosphamide; a deuterated analog of Nor-nitrogen mustard.

Uses

Bis(2-chloroethyl)amine hydrochloride is used as an intermediate in chemicals synthesis and building block for piperazine derivatives.

Safety Profile

A poison by inhalation,intraperitoneal, intramuscular, and subcutaneous routes.An experimental teratogen. Human mutation datareported. When heated to decomposition it emits toxicfumes of NH3, NOx, and Cl-.

Synthesis

111-42-2

821-48-7

31.5 g (0.30 mol) of diethanolamine and 300 mL of dichloroethane were added to a 1 L round-bottomed flask equipped with a reflux condensing unit, followed by the slow dropwise addition of 51.0 mL of thionyl chloride. Immediately after the dropwise addition, the formation of a solid suspension was observed, and the suspension gradually dissolved as the temperature was raised to 50 °C. Stirring of the reaction mixture was continued under reflux conditions, during which the precipitation of crystalline solids was observed. Reflow was maintained and stirring was continued for 3 hours. Upon completion of the reaction, 20 mL of methanol was added to quench the reaction, followed by evaporation of the solvent under reduced pressure. The final white crystalline product bis(2-chloroethyl)amine hydrochloride was obtained in 53.0 g in quantitative yield.

Purification Methods

Crystallise the salt from Me2CO or MeOH/Et2O. The picrate has m 112-113o (from EtOH or Me2CO). [Mann J Chem Soc 464 1934, Ward J Am Chem Soc 57 915 1935,

References

[1] Patent: US2015/299113, 2015, A1. Location in patent: Paragraph 0043
[2] Phosphorus, Sulfur and Silicon and the Related Elements, 2017, vol. 192, # 2, p. 231 - 234
[3] Patent: CN106397356, 2017, A. Location in patent: Paragraph 0045; 0060; 0066; 0074; 0082; 0090; 0098
[4] Patent: EP2682390, 2014, A1. Location in patent: Paragraph 0018; 0080
[5] Synthesis, 2010, # 16, p. 2705 - 2707

Bis(2-chloroethyl)amine hydrochloride synthesis

Synthesis of Bis(2-chloroethyl)amine hydrochloride from Diethanolamine

Bis(2-chloroethyl)amine hydrochloride Preparation Products And Raw materials

Raw materials

Diethanolamine 1,2-Dichloroethane Thionyl chloride

Preparation Products

1-(3-METHYLPHENYL)PIPERAZINE N-(3-Trifluoromethylphenyl)piperazine 1-AMINO-4-(2-HYDROXYETHYL)PIPERAZINE 1-(4-Methoxyphenyl)piperazine dihydrochloride 1-CYCLOPROPYLPIPERAZINE

1-(3-NITROPHENYL)-PIPERAZINE 3-(4-methylpiperazin-1-yl)phenylboronic acid 1-(2-Methoxyphenyl)piperazine hydrobromide 1-(4-Methoxyphenyl)piperazine 3-(4-PHENYL-PIPERAZIN-1-YL)-PROPIONIC ACID

1-(4-METHYLPHENYL)PIPERAZINE 1-(3-Chlorophenyl)piperazine dihydrochloride Thiomorpholine 1-(2-ETHOXYPHENYL)PIPERAZINE HYDROCHLORIDE 4-(4-Methylpiperazin-1-yl)phenylboronic Acid

1-(4-Chlorophenyl)piperazine 4-CYANO-4-PHENYLPIPERIDINE HYDROCHLORIDE 1-(2-Methylphenyl)piperazine 1-(1-PHENYLETHYL)PIPERAZINE (4-PHENYL-PIPERAZIN-1-YL)-ACETIC ACID

Tert-butyl bis(2-chloroethyl)carbamate 1-(3-FLUOROPHENYL)PIPERAZINE 1-[2-(MORPHOLIN-4-YL)-ETHYL]-PIPERAZINE N-(2-Methylphenyl)piperazine hydrochloride 1-(3,4-Dichlorophenyl)piperazine

1-(2-FLUOROPHENYL)PIPERAZINE HYDROCHLORIDE 1-(3-Methoxyphenyl)piperazine 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE 1-(3,5-DICHLOROPHENYL)PIPERAZINE

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Bis(2-chloroethyl)amine hydrochloride Suppliers

Global( 652)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5242	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
airuikechemical co., ltd.	+86-18353166132	sales02@airuikechemical.com	China	983	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3692	58
Moxin Chemicals	+86-17320513646 +8617320513646	anna@molcoo.com	China	10000	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13620	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21599	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
airuikechemical co., ltd.	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Moxin Chemicals	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60

View Lastest Price from Bis(2-chloroethyl)amine hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-27	Bis(2-chloroethyl)amine hydrochloride 821-48-7	US $0.00 / Kg/Drum	1KG	≥99%	100mt/year	Jinan Finer Chemical Co., Ltd
2026-01-05	Bis(2-chloroethyl)amine hydrochloride 821-48-7	US $29.00 / g		≥95%	10g	TargetMol Chemicals Inc.
2026-01-04	Bis(2-chloroethyl)amine hydrochloride 821-48-7	US $29.00 / g		≥95%	10g	TargetMol Chemicals Inc.

Bis(2-chloroethyl)amine hydrochloride
821-48-7
US $0.00 / Kg/Drum
≥99%
Jinan Finer Chemical Co., Ltd

Bis(2-chloroethyl)amine hydrochloride
821-48-7
US $29.00 / g
≥95%
TargetMol Chemicals Inc.

Bis(2-chloroethyl)amine hydrochloride
821-48-7
US $29.00 / g
≥95%
TargetMol Chemicals Inc.

Bis(2-chloroethyl)amine hydrochloride Spectrum

Bis(2-chloroethyl)amine hydrochloride(821-48-7)MS Bis(2-chloroethyl)amine hydrochloride(821-48-7)¹HNMR Bis(2-chloroethyl)amine hydrochloride(821-48-7)¹³CNMR Bis(2-chloroethyl)amine hydrochloride(821-48-7)IR1 Bis(2-chloroethyl)amine hydrochloride(821-48-7)IR2 Bis(2-chloroethyl)amine hydrochloride(821-48-7)Raman

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BIS (2-CHLOROETHYL) AMINE HCL BIS(2-CHLOROETHYL)AMINE HYDROCHLORIDE BIS(2-CHLOROETHYL)AMMONIUM CHLORIDE DI-(2-CHLOROETHYL)AMINE HYDROCHLORIDE 2,2'-DICHLORODIETHYLAMINE HYDROCHLORIDE 2,2’-dichloro-diethylaminhydrochloride 2-chloro-n-(2-chloroethyl)ethanaminehydrochloride 2-chloro-n-(2-chloroethyl)-ethanaminhydrochloride beta,beta’-dichlorodiethylaminehydrochloride bis(beta-chloroethyl)-aminehydrochloride Bis(2-chloroethyl)amine hydrochloride ,99% Bis(2-chloroethyl)am N,N-BIS-(2-Chloroethyl)-aMine Hcl 2-Chloro-N-(2-chloroethyl)ethylamine hydrochloride Cyclophosphamide Related Compound A (25 mg) (bis(2-chloroethyl)amine hydrochloride) (International Restricted Sales Item) Bis 2-ChloroethylaMine.HCl Solid is(2-chloroethyl)aMine hydrochloride Bis(2-chloroethyl)aMine hydrochloride, 98% 100GR di(chloroethyl)aMino HCL Ethanamine, 2-chloro-N-(2-chloroethyl)-, hydrochloride Bis(2-chloroethyl)amine hydrochloride 98% Bis(2-chloroethyl)ammonium chloride for synthesis Bis(2-chlorolthyl)amine hydro-chloride BIS(2-CHLOROETHYL)AMINE HYDROCHLORIDE, 9 8% Bis-(2-ChloroEthyl)AminHcl Bis-(Chloroethyl)AmineHcl CyclophosphaMide Related CoMpound A EthanaMine,2-chloro-N-(2-chloroethyl)-, hydrochloride (1:1) Two(2-chloro ethyl)aMine hydrochloride Two (2 - ethyl chloride) aMine hydrochloride leo72a n,n-bis(2-chloroethyl)aminehydrochloride nc26 nor-hn2hydrochloride nor-losthydrochlorid nornitrogenmustardhydrochloride nsc10873 sk555 tl161 BIS(2-CHLOROETHYL)AMINEMONOHYDROCHLORIDE Bis(2-chL N,N-di(2-chloroethyl)amine hydrochloride bis(2-chloroethyl)azanium chloride 2-Chloro-N-(2-Chloroethyl)Ethanami Bis(2-chloroethyl)amine hydrochloride (solid) Bis(2-chlorolethyl)aminehydro-chloride Diethylamine, 2,2'-dichloro- hydrochloride Aripiprazole Impurity 33 USP Cyclophosphamide Related Compound A Cyclophosphamide Related Compound A HCl BIS(2-CHLOROETHYL)AMMONIUM CHLORIDE FOR Cyclophosphamide USP RC A BIS(2-CHLOROETHYL)AMINE HYDROCHLORIDE 821-48-7 Bis (2-chloroethyl) amine HCI Cyclophosphamide Related Compound A (bis(2-chloroethyl)amine hydrochloride) (1157013) 3-[(Z)-octadec-9-enoyl]oxypropyl (Z)-octadec-9-enoate Adomiparin Eparina